Results 41 to 50 of about 53,142 (237)

Physiologically‐Based Pharmacokinetic Modeling of Atorvastatin Incorporating Delayed Gastric Emptying and Acid‐to‐Lactone Conversion

CPT: Pharmacometrics & Systems Pharmacology, 2019
The drug–drug interaction profile of atorvastatin confirms that disposition is determined by cytochrome P450 (CYP) 3A4 and organic anion transporting polypeptides (OATPs).
Bridget L. Morse, Jeffrey J. Alberts, Maria M. Posada, Jessica Rehmel, Anil Kolur, Lai San Tham, Corina Loghin, Kathleen M. Hillgren, Stephen D. Hall, Gemma L. Dickinson   +9 more
doaj   +1 more source

Thermodynamic and Thermomicroscopy Study of Atorvastatin Calcium-Succinic Acid Binary Mixtures

Indonesian Journal of Chemistry, 2017
Binary mixtures of pharmaceuticals significantly affect the physical and chemical properties of each component. The aim of this work was to explore the thermal behavior and solid state transformation of binary mixture of atorvastatin calcium and succinic
Yudi Wicaksono, Budipratiwi Wisudyaningsih, Frida Oktaningtias Widiarthi, Tri Agus Siswoyo   +3 more
doaj   +1 more source

Plant sterol or stanol esters retard lesion formation in LDL receptor-deficient mice independent of changes in serum plant sterols

Journal of Lipid Research, 2006
Statins do not always decrease coronary heart disease mortality, which was speculated based on increased serum plant sterols observed during statin treatment.
Jogchum Plat, Ilona Beugels, Marion J.J. Gijbels, Menno P.J. de Winther, Ronald P. Mensink   +4 more
doaj   +1 more source

Effect of atorvastatin therapy on oxidant-antioxidant status and atherosclerotic plaque formation [PDF]

, 2011
Ebru Demirel Sezer1, Eser Yildirim Sozmen1, Deniz Nart2, Taner Onat11Medical Biochemistry, 2Pathology Department, Ege University School of Medicine, Izmir, TurkeyBackground: The aim of this study was to determine the oxidant–antioxidant status and ...
Nart, Sezer E.D., Nart D., null Sozmen, Onat T., Onat, null Nart, Ebru Sezer, null Onat, Sozmen E.Y., Sezer E, Sozmen   +11 more
core   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Switching Therapy to the Second Brand of Generic Atorvastatin: A 6-Month Retrospective Cohort, Real-World Study

Drugs - Real World Outcomes
Introduction High levels of low-density lipoprotein-cholesterol (LDL) is a major risk factor for cardiovascular diseases. While treatment with atorvastatin is beneficial, the original atorvastatin may be cost prohibitive to some patients.
Panisa Manasirisuk, Somsak Tiamkao, Chaiyasith Wongvipaporn, Nanthaphan Chainirun, Kittisak Sawanyawisuth   +4 more
doaj   +1 more source

Atorvastatin-induced CD59 and decay-accelerating factor in hypoxia enhance endothelial cell cytoprotection

, 2011
Copyright information:Taken from "Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis"Arthritis Research & Therapy 2006;8(4):R130-R130.Published ...
Sarah K Harten (23391), Patrick H Maxwell (23394), Anne R Kinderlerer (23388), Michael Johns (23390), Rivka Steinberg (23389), Elaine A Lidington (23392), Justin C Mason (23395), Dorian O Haskard (23393)   +7 more
core   +1 more source

Absence of a significant pharmacokinetic interaction between atorvastatin and fenofibrate: A randomized, crossover, study of a fixed-dose formulation in healthy Mexican subjects

Frontiers in Pharmacology, 2015
Several clinical trials have substantiated the efficacy of the co-administration of statins like atorvastatin and fibrates. Without information currently available about the interaction between the two drugs, a pharmacokinetic study was conducted to ...
Omar ePatiño-Rodríguez, Rosa María eMartínez-Medina, Irma eTorres-Roque, Maricela eMartínez-Delgado, America Susana Mares-Garcia, Abraham eEscobedo-Moratilla, Amador eCovarrubias-Pinedo, Angélica eArzola-Paniagua, José Luis eHerrera-Torres, José ePérez-Urizar   +9 more
doaj   +1 more source

Prediction and validation of common targets in atherosclerosis and non-small cell lung cancer influenced by atorvastatin

BMC Complementary Medicine and Therapies, 2023
Background Cardiovascular disease and cancer are the main causes of morbidity and mortality worldwide. Studies have shown that these two diseases may have some common risk factors.
Yu-qian Li, Lu-yao Li, Xue Yang, Qi-qi Lei, Liu-yan Xiang, Yuan-ru Wang, Si-meng Gu, Ya-jun Cao, Yan Pan, Lu Tie, Xue-jun Li   +10 more
doaj   +1 more source

Optimization of pharmaceutical research and development by early‐phase assessment of investigational medicinal products

British Journal of Clinical Pharmacology, EarlyView.
Small and mid‐sized pharmaceutical innovators often have limited in‐house health economics and market access expertise, and may struggle to align development strategies of investigational medicinal products with health system needs and payer expectations.
Zoltán Kaló, Attila Imre, Gábor Varga, Sándor Kovács, György Tímár, Balázs Nagy   +5 more
wiley   +1 more source