Results 171 to 180 of about 56,049 (248)

Atorvastatin Exerts Context-Dependent Metabolic and Beneficial Effects on Behavior and Apoptotic Signaling in a Cafeteria Diet-Induced Metabolic Dysfunction Model. [PDF]

Neurochem Res
Diogo ÍL, Maia GAS, Garcia IJP, de Lima Santos H, Cortes VF, Barbosa LA, Chaves VE, Carvalho LED.   +7 more
europepmc   +1 more source

Mechanism‐Informed Pharmacotherapy Optimization and Deprescribing: A Redox–Mitochondrial Framework

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
From cumulative drug burden to mitochondrial stress and functional decline. The graphical abstract summarizes the central concept of the review, illustrating how cumulative pharmacotherapy exposure may contribute to redox–mitochondrial stress and thereby reduce biological and functional resilience.
Boštjan Martinc
wiley   +1 more source

Mechanisms and Predisposing Conditions for Statin-Induced New-Onset Type 2 Diabetes Mellitus: A Paradox Relative to Their Pleiotropic Metabolic Effects. [PDF]

Endocrinol Diabetes Metab
Andevari AN, Koolivand M.
europepmc   +1 more source

Real‐World Claims Data on Prescribed Drugs and the Associated Drug–Drug Interaction Risk in Sickle Cell Disease in the United States

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
Real‐world prescription data from 6230 adolescents and adults living with sickle cell disease (SCD) were combined with a drug–drug interaction (DDI) database to characterize the population‐level DDI risk. The findings support a DDI risk assessment for development of novel SCD therapies and during clinical management of SCD.ABSTRACTSickle cell disease ...
Rune Aabjerg Nørgaard, Laura Grenier, Peter Bruun‐Rasmussen, Ifeyinwa Osunkwo, Carolina Säll   +4 more
wiley   +1 more source

The impact of concomitant use of rosuvastatin or atorvastatin plus clopidogrel on the platelet inhibition and clinical outcomes in acute large-vessel minor stroke or TIA: A randomized controlled multi-center trial, the ROCATIS-1 trial. [PDF]

Ther Adv Neurol Disord
Zeinhom MG, Sayed Ismaiel MG, Khalil MFE, Elmesallami AG, Khalil GAE, Akl AZO, Georgy SS, Abbas AA, Kerolos YSS, Abdeldayem SM, Khalil EHE, Mostafa E, Youssif TYO, Egila AAE, Alkhalefeh AG, Hassan AM, Zedan TS, Ghoname AE, Mahmoud ELA, Mushtaque A, Abdelkhalek AM, Ghazi EAA, Ahmed SR.   +22 more
europepmc   +1 more source

From Real World Data to Real Impact: A Co‐Medication Framework for Lung Cancer to Advance DDI Assessment and Patient‐Centric Drug Development

Clinical and Translational Science, Volume 19, Issue 10, October 2026.
ABSTRACT Lung cancer predominantly affects older adults who already experience comorbidities and are at increased risk of drug–drug interactions (DDIs) due to polypharmacy. Traditional DDI assessments often do not fully capture complex co‐medication patterns observed in real‐world practice due to the risk of introducing confounding factors.
Mareena Biju, HeeJae Choi, Shilpa Madari, Annie Carlisle, Ashish Sharma, Christina Kunz, Fenglei Huang   +6 more
wiley   +1 more source

Comparative effects of atorvastatin and rosuvastatin on inflammatory biomarkers: a systematic review and meta-analysis of randomized head-to-head trials. [PDF]

BMC Cardiovasc Disord
Omayer A, Mohamed MI, Shahid M, Hoque SMH, Mohamed NEAM, Elsayed EMA, Nassar M, Ahmed T, Sattar Y.   +8 more
europepmc   +1 more source

Clinical management of clonal hematopoiesis

Cancer, Volume 132, Issue 18, 15 September 2026.
ABSTRACT Clonal hematopoiesis, particularly clonal hematopoiesis of indeterminate potential and clonal cytopenia of undetermined significance, is an age‐related premalignant condition characterized by the expansion of hematopoietic clones carrying somatic mutations.
Kelly S. Chien, Guillermo Garcia‐Manero   +1 more
wiley   +1 more source

Structural basis for rosuvastatin-induced activation of skeletal muscle ryanodine receptor 1. [PDF]

Nat Commun
Weninger G, Reiken S, Yuan Q, Miotto MC, Chang A, Liu Y, Wronska A, Dridi H, Marks AR.   +8 more
europepmc   +1 more source

Thermoresponsive Solid Dispersion to Enhance Dissolution Profile of Atorvastatin Calcium: An Industrially Sustainable Alternative to Conventional Approaches. [PDF]

Pharmaceutics
Sherif AY, Ibrahim MA.
europepmc   +1 more source