Results 71 to 80 of about 57,678 (240)

Association between CYP3A4/CYP3A5 genetic polymorphisms and treatment outcomes of atorvastatin worldwide: is there enough research on the Egyptian population?

European Journal of Medical Research, 2023
Introduction Atorvastatin is regarded as the most frequently prescribed statin worldwide for dyslipidemia. However, clinical response and risk of adverse effects to statin therapy are associated with genetic variations.
Mohammed G. Maslub, Mahasen A. Radwan, Nur Aizati Athirah Daud, Abubakar Sha’aban   +3 more
doaj   +1 more source

Avaliação da associação entre o efeito neuroprotetor e antidepressivo da atorvastatina em camundongos: [dissertação] [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.A excitotoxicidade glutamatérgica têm sido correlacionada com a patofisiologia da depressão e a modulação deste ...
Ludka, Fabiana Kalyne
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Effect of atorvastatin on energy metabolism of the blue mussels, Mytilus edulis

, 2019
Increasing concentration of biologically active pharmaceutical compounds can affect marine organisms. The bioavailability and environmental stability of these compounds make them potential threat to these organisms, specially the sessile organisms.
Sabrina Glufke (7884569), Udo Kragl (7884563), Stock, Marius, Falfushynska, Halina, Ruth, Wolfgang, Sokolova, Inna M, Fouzia Haider (7883918), Wolfgang Ruth (2325415), Oppermann, Christina, Eileen J Winkel (7884572), Glufke, Sabrina, Marius Stock (7884566), Inna M Sokolova (7398920), Christina Oppermann (7884560), Winkel, Eileen J, Kragl, Udo, Haider, Fouzia, Eugene P Sokolov (7884557), Halina Falfushynska (7398923), Sokolov, Eugene P   +19 more
core   +1 more source

Dispensing of actionable pharmacogenetic drugs among adults receiving cardiovascular disease medications in the Northern Netherlands: A serial cross‐sectional study

Clinical Pharmacology &Therapeutics, EarlyView.
The extent of pharmacogenetic (PGx) drug dispensing among Dutch adults receiving medications for cardiovascular disease (CVD) is unknown. Using the University of Groningen IADB.nl pharmacy database, we performed a serial cross‐sectional study (2019–2023) to estimate the annual prevalence of PGx drug dispensing and annual rates of initiation.
Zhuolin Zhang, Guiling Zhou, Jens H. J. Bos, Eelko Hak, Talitha Feenstra, Frank Klont   +5 more
wiley   +1 more source

Structural Changes of the Pancreas in Female Albino Rats Treated with the Atorvastatin and the Alleviating Effect of Propolis : Histological and Biochemical Study [PDF]

The Egyptian Journal of Histology
Introduction: Atorvastatin is "HMG-COA" reductase inhibitors" that is widely used for management of hyperlipidemia particularly in patients with risk of cardio and cerebrovascular stroke.
Eman sheet, zahraa taboo, waleed kasim
doaj   +1 more source

The effect of anti‐seizure medications on exposure to statins: A systematic review and meta‐analysis

Epileptic Disorders, EarlyView.
Abstract Objectives Antiseizure medications (ASMs) can reduce the efficacy of statin treatment, partly due to reduction in statin concentrations. In this systematic review and network meta‐analysis (NMA), we compared the effects of ASMs and the prototypical enzyme inducer rifampin on statin exposure.
Sharon Valiyev Huino, Hagar Cohen, Bruria Hirsh Raccah, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +5 more
wiley   +1 more source

Fenofibrate ameliorated atorvastatin and piperine-induced ROS mediated reproductive toxicity in male Wistar rats

Toxicology Reports
Atorvastatin and fenofibrate are well-known lipid-lowering drugs. Atorvastatin acts by reducing the production of cholesterol through the inhibition of the 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG Co-A reductase) enzyme, whereas fenofibrate ...
Sanjib Ghosh, Sweata Sarkar, Maharaj Biswas   +2 more
doaj   +1 more source

Statin use and risk of remote seizure after first new onset status epilepticus

Epilepsia, EarlyView.
Abstract Objective Preclinical evidence supports the role of statins as antiepileptogenic agents. In this study, we investigated the risk of remote unprovoked seizures (RS) according to the use of statin therapy in a cohort of first‐ever status epilepticus (SE) survivors. Methods Retrospective analysis was made of adult patients (age ≥ 14 years) with a
Niccolò Orlandi, Giada Giovannini, Lisa Taruffi, Margherita Burani, Jefe Laureine Ngnintedem Dontsop, Mara Malerba, Simona Scolastico, Laura Madrassi, Leonardo Affronte, Matteo Pugnaghi, Anna Elisabetta Vaudano, Simona Lattanzi, Stefano Meletti   +12 more
wiley   +1 more source

Atorvastatin action involves diminished recovery of hepatic HMG-CoA reductase activity

Journal of Lipid Research, 1998
The effects of atorvastatin on the expression of the hepatic HMG-CoA reductase and LDL receptor genes were investigated in rats. Like the other statins, atorvastatin increased the rate of degradation and presumably cycling of the hepatic LDL receptor. In
Gene C. Ness, Christopher M. Chambers, Dayami Lopez   +2 more
doaj   +1 more source

Atorvastatin Induces Thrombomodulin Expression in the Aorta of Cholesterol -Fed Rabbits and in Tnf Alpha-Treated Human Aortic Endothelial Cells

, 2011
Expression of functionally active thrombomodulin (TM) on endothelial cells is critical for vascular thromboresistance . 3-Hydroxyl-3-methyl coenzyme A reductase inhibitors ( statins) can protect the vasculature from inflammation and atherosclerosis ...
林幸榮;謝芳瑜;陳永祥;林家齊;管奕奕;王淑慧;吳造中;簡雄飛;林豐彥;陳玉怜, LIN, SHING-JONG;HSIEH, FANG-YU;CHEN, YUNG-HSIANG;LIN, CHIA-CHI;KUAN, I-I;WANG, SHU-HUEI;WU, CHAU-CHUNG;CHIEN, HSIUNG-FEI;LIN, FENG-YEN;CHEN, YUH-LIEN   +1 more
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