Results 11 to 20 of about 51,582 (258)

Immunomodulatory effects of atorvastatin on MRL/lpr mice

Advances in Rheumatology, 2022
Background Statins have long been extensively prescribed as effective lipid-lowering agents, but statins have also been recognized as novel immunomodulators in recent years.
Jing Sun, Weidong Xu, Zhiying Wu, Caijin Cao, Yane Tan, Meifang Zhu, Hongze Wu, Jianping Yu   +7 more
doaj   +1 more source

Effects of short-term treatment with atorvastatin in smokers with asthma - a randomized controlled trial [PDF]

, 2011
<b>Background</b> The immune modulating properties of statins may benefit smokers with asthma. We tested the hypothesis that short-term treatment with atorvastatin improves lung function or indices of asthma control in smokers with asthma.<
Chaudhuri, Rekha, Lloyd, Suzanne M., Spears, Mark, Thomson, Neil C., Iona Donnelly, Lloyd, Suzanne M, Jolly, Lisa, Mair, Frances, Braganza Georgina, Mair Frances, Weir Christopher J, Frances Mair, Mark Spears, McSharry, Charles, Lafferty Jane, Christopher J Weir, Lloyd Suzanne M, McSharry Charles, Lisa Jolly, Braganza, Georgina, Weir, Christopher J., Spears, Mark; id_orcid, Lafferty, Jane, Rekha Chaudhuri, Charles McSharry, Thomson Neil C, Georgina Braganza, Thomson, Neil C, Chaudhuri Rekha, Neil C Thomson, Jane Lafferty, Suzanne M Lloyd, Spears Mark, Donnelly, Iona, Weir, Christopher J; id_orcid, Donnelly Iona, Jolly Lisa   +36 more
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Atorvastatin suppresses lipopolysaccharide-induced inflammation in human coronary artery endothelial cells

Brazilian Journal of Pharmaceutical Sciences, 2022
The present study was designed to examine the effects of atorvastatin on vascular inflammatory responses in human coronary artery endothelial cells(HCAECs), when challenged by lipopolysaccharide (LPS), a Toll-like receptor-4 (TLR4) ligand.
Zhen Tian, Zhitao Li, Tian Guo, He Li, Yanshuang Mu   +4 more
doaj   +1 more source

Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importnace of Lp(a) [PDF]

, 2012
We carried out a genome-wide association study (GWAS) of LDL-c response to statin using data from participants in the Collaborative Atorvastatin Diabetes Study (CARDS; n = 1,156), the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT; n = 895), and the ...
Postmus, Iris, Colhoun, H.M., McKeigue, Paul M, Stanton, A.V., Trompet, S., Hyde, Craig, Colhoun, Helen M, Caulfield, M., Shields, Denis C., Hitman, Graham A, CARDS, Poulter, Neil, Shields, D.C., Sever, P., Chatterjee, Aurobindo, Trompet, Stella, Durrington, Paul N, Deshmukh, H.A., DeMicco, D.A., Calle, Roberto A., Hitman, Graham A., Neil, A., McKeigue, Paul M., Fuller, John H., Postmus, I., Hitman, G.A., DeMicco, David A., Johnson, T., ?, ?, Calle, Roberto A, Betteridge, D.J., Livingstone, Shona, Ford, Ian, McKeigue, P.M., Stanton, Alice V., Jukema, J.W., Johnson, Toby, Durrington, Paul N., Neil, Andrew, PROSPER Investigators, Livingstone, S., Jukema, J. Wouter, ASCOT, Colhoun, Helen, Ford, I., Sever, Peter, Fuller, J.H., Jukema, J Wouter, Caulfield, Mark, Fuller, John H, Chatterjee, A., Deshmukh, Harshal A, Calle, R.A., Hyde, C., Charlton-Menys, V., Poulter, N., Charlton-Menys, Valentine, DeMicco, David A, Betteridge, D John, McKeigue, Paul M.; id_orcid, Betteridge, D. John, Durrington, P.N., Colhoun, Helen M., Shields, Denis C, Deshmukh, Harshal A., Stanton, Alice V   +65 more
core   +1 more source

Atorvastatin and Clopidogrel [PDF]

Circulation, 2003
To the Editor: I would like to comment on the recent editorial by Serebruany et al1 in which the study results by Lau et al2 are discussed. It is argued that these results, which are suggestive of a clinically relevant interaction between clopidogrel and atorvastatin, are in conflict with those published previously by Serebruany et al.3 According to ...
openaire   +2 more sources

Efficacy and Safety of Alirocumab as Add-on Therapy in High–Cardiovascular-Risk Patients With Hypercholesterolemia Not Adequately Controlled With Atorvastatin (20 or 40 mg) or Rosuvastatin (10 or 20 mg)::Design and Rationale of the ODYSSEY OPTIONS Studies [PDF]

, 2014
The phase 3 ODYSSEY OPTIONS studies (OPTIONS I, NCT01730040; OPTIONS II, NCT01730053) are multicenter, multinational, randomized, double-blind, active-comparator, 24-week studies evaluating the efficacy and safety of alirocumab, a fully human monoclonal ...
Peter H. Jones, Robinson, Jennifer G., Hanotin, Corinne, Du, Yunling, Jones, Peter H., Harold E. Bays, Corinne Hanotin, Yunling Du, Colhoun, Helen M., Donahue, Stephen, Jennifer G. Robinson, Helen M. Colhoun, Stephen Donahue, Bays, Harold E.   +13 more
core   +1 more source

A randomized, open-label, parallel, multi-center Phase IV study to compare the efficacy and safety of atorvastatin 10 and 20 mg in high-risk Asian patients with hypercholesterolemia.

PLoS ONE, 2021
BackgroundAlthough accumulating evidence suggests a more extensive reduction of low-density lipoprotein cholesterol (LDL-C), it is unclear whether a higher statin dose is more effective and cost-effective in the Asian population.
Ji Bak Kim, Woo Hyuk Song, Jong Sung Park, Tae-Jin Youn, Yong Hyun Park, Shin-Jae Kim, Sung Gyun Ahn, Joon-Hyung Doh, Yun-Hyeong Cho, Jin Won Kim   +9 more
doaj   +1 more source

Pharmacokinetics and Genetic Factors of Atorvastatin in Healthy Korean Subjects

Frontiers in Genetics, 2022
Background: Statins are the most popular agents for the primary and secondary prevention of cardiovascular disease; however, the pharmacokinetic parameters and associated genetic factors in the Korean population have not been fully elucidated. This study
Serim Kim, Jong Do Seo, Yeo-Min Yun, Yeo-Min Yun, Hanah Kim, Hanah Kim, Tae-Eun Kim, Taeheon Lee, Tae-Rim Lee, Jun Hyung Lee, Eun-Hae Cho, Chang-Seok Ki   +11 more
doaj   +1 more source

Atorvastatin-loaded peptide amphiphiles against corneal neovascularization - supplementary material

, 2023
Background: Corneal neovascularization is a sight-threatening disease. It can be treated using antiangiogenic and anti-inflammatory compounds. Therefore, atorvastatin (ATV) constitutes a suitable candidate to be administered topically. To attain suitable
Elena Sanchez-Lopez (16870506), Isabel Haro (2148178), Maria Jose Gomara (16870508)   +2 more
core   +1 more source

Combined Beneficial Effect of Genistein and Atorvastatin on Adipogenesis in 3T3-L1 Adipocytes

Biomolecules, 2021
Genistein (4,5,7-trihydroxyisoflavone) is abundant in various dietary vegetables, especially soybeans, and is known to have not only an estrogenic effect but also an antiadipogenic effect.
Dahae Lee, Ji-Youn Kim, Hae-Won Kim, Jeong-Eun Yoo, Ki Sung Kang   +4 more
doaj   +1 more source