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Atorvastatin for Anthracycline-Associated Cardiac Dysfunction: The STOP-CA Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2023
Importance Anthracyclines treat a broad range of cancers. Basic and retrospective clinical data have suggested that use of atorvastatin may be associated with a reduction in cardiac dysfunction due to anthracycline use.
T. Neilan   +34 more
semanticscholar   +1 more source

Atorvastatin inhibits neuronal apoptosis via activating cAMP/PKA/p‐CREB/BDNF pathway in hypoxic‐ischemic neonatal rats

The FASEB Journal, 2022
Neuronal apoptosis is one of the main pathological processes of hypoxic‐ischemic brain damage (HIBD) and is involved in the development of hypoxic‐ischemic encephalopathy (HIE) in neonates.
Luting Yu   +10 more
semanticscholar   +1 more source

Atorvastatin ameliorates early brain injury after subarachnoid hemorrhage via inhibition of pyroptosis and neuroinflammation

Journal of Cellular Physiology, 2021
Subarachnoid hemorrhage (SAH) is a subtype of stroke with high mortality and morbidity due to the lack of effective therapy. Atorvastatin has been reported to alleviate early brain injury (EBI) following subarachnoid hemorrhage (SAH) via reducing ...
Junhui Chen   +7 more
semanticscholar   +1 more source

Chitosan-encapsulated niosomes for enhanced oral delivery of atorvastatin

Journal of Drug Delivery Science and Technology, 2021
Atorvastatin is the most commonly used hypolipidemic drug. It provides excellent protection against cardiovascular disease especially in subjects having high risk factors. However, atorvastatin has problematic biopharmaceutical characteristics due to low
Noha D. Fayed   +3 more
semanticscholar   +1 more source

Atorvastatin

Expert Opinion on Pharmacotherapy, 2005
The introduction of statins has drastically changed the treatment and prevention of atherosclerotic vascular disease. By lowering lipid levels and reducing the risk of coronary heart disease, these drugs are among the most effective at reducing morbidity and mortality available to clinical practice.
Sander I, van Leuven   +1 more
openaire   +2 more sources

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