Results 211 to 220 of about 106,444 (303)

H2‐dependent modulation of tetrahydromethanopterin S‐methyltransferase (Mtr complex) activity by the small protein MtrR in Methanosarcina mazei

The FEBS Journal, EarlyView.
Small protein MtrR is a regulator of the Mtr methyltransferase complex in Methanosarcina mazei. It binds specifically to the MtrA subunit and modulates Mtr activity in response to hydrogen (H2) availability. Deleting mtrR impairs growth in the presence but not absence of H2, indicating its role in directing methyl transfer toward an energy‐conserving ...
Tim Habenicht, Bjarne Hastedt, Liam Cassidy, Claudia Kießling, Andreas Tholey, Jan M. Schuller, Ruth A. Schmitz   +6 more
wiley   +1 more source

c-MET tyrosine kinase inhibitors reverse drug resistance mediated by the ATP-binding cassette transporter B1 (ABCB1) in cancer cells. [PDF]

3 Biotech
Nazari S, Poustforoosh A, Paul PR, Kukreti R, Tavakkoli M, Saso L, Firuzi O, Moosavi F.   +7 more
europepmc   +1 more source

Variability in intracellular localization of D‐amino acid oxidase in choroid plexus epithelial cells

The FEBS Journal, EarlyView.
D‐amino acid oxidase (DAO) in choroid plexus epithelial cells (CPECs) shows vesicle‐like localization by histological and super‐resolution analyses. DAO colocalizes with peroxisomal, Golgi, endosomal, lysosomal, autophagosomal, and exosomal markers, indicating diverse subcellular distribution. This suggests DAO is transported within CPECs to metabolize
Koji Ono, Yuji Shishido, Toshiyuki Yamagishi, Kiyoshi Fukui   +3 more
wiley   +1 more source

Action of 3-Hydroxy-3-Methylglutaryl-CoA Reductase Inhibitors on ABCA-1 protein (ATP-Binding Cassette Transporter-1) in endothelial cells stimulated with uremic serum. [PDF]

Lipids Health Dis
de Melo Carmona S, Jardim DP, Dalboni MA, Nakamichi R, Kuniyoshi M, Marrocos M, Quinto BMR, Batista MC.   +7 more
europepmc   +1 more source

Functional Significance of Conserved Cysteines in the Extracellular Loops of the ATP Binding Cassette Transporter Pdr11p. [PDF]

J Fungi (Basel), 2020
Stanchev LD, Marek M, Xian F, Klöhn M, Silvestro D, Dittmar G, López-Marqués RL, Günther Pomorski T.   +7 more
europepmc   +1 more source

Arsenite methyltransferase 3 is required for mitochondrial function and hepatic lipid metabolism

The FEBS Journal, EarlyView.
AS3MT is a protein that helps the body process arsenic, a naturally occurring toxin found in water and soil. We discovered it also helps cells make and use energy properly. Without AS3MT, cells' mitochondria do not work well, leading to fatty liver and reduced activity. Increasing AS3MT in liver cells restores energy and protects against arsenic damage,
Patrice Delaney, James Griffin, Nouf Khan, Balnur Ibrash, Matthew J. O'Connor, Tomas Venit, Elizabeth Mayela Ambrosio, Spiros A. Pergantis, Elke Ober, Piergiorgio Percipalle, Kirsten C. Sadler   +10 more
wiley   +1 more source

ATP-binding cassette transporter inhibitor potency and substrate drug affinity are critical determinants of successful drug delivery enhancement to the brain. [PDF]

Fluids Barriers CNS
Lentzas A, de Gooijer MC, Zuidema S, Meurs A, Çitirikkaya CH, Venekamp N, Beijnen JH, van Tellingen O.   +7 more
europepmc   +1 more source

Cytosolic delivery of bacterial metabolites by riboflavin transporters promotes MR1 antigen presentation and MAIT cell recognition

Immunology &Cell Biology, EarlyView.
VitBAg antigen presentation is promoted through a cytosolic pathway that reaches ligand‐receptive MR1 to present to MAIT cells, like the riboflavin transport pathway. Riboflavin solute carrier transporters can promote this MR1 presentation, but they are not essential for this role, suggesting redundant pathways to uptake VitBAg.
Sebastian Cruz‐Gomez, Hui Jing Lim, Brunda Nijagal, Yuting Yang, Nicole Lau, Jeffrey YW Mak, David P Fairlie, Hayley Newton, Mariolina Salio, Jose A Villadangos, Hamish EG McWilliam   +10 more
wiley   +1 more source

Membrane-assisted tariquidar access and binding mechanisms of human ATP-binding cassette transporter P-glycoprotein. [PDF]

Front Mol Biosci
Gao Y, Wei C, Luo L, Tang Y, Yu Y, Li Y, Xing J, Pan X.   +7 more
europepmc   +1 more source

Hybrid sorghum breeding in China: A historical review and perspectives

Journal of Integrative Plant Biology, EarlyView.
To commemorate the 60th anniversary of the promotion and application of three‐line hybrid sorghum in China, this review highlights pivotal scientific breakthroughs, systematically summarizes the progress in hybrid sorghum breeding and dwarf sorghum breeding in the country, and presents an outlook on the future of sorghum breeding.
Xiangxiang Meng, Lu Li, Qian Qian, Liang Jiang, Zhaosheng Kong   +4 more
wiley   +1 more source