Results 11 to 20 of about 156,745 (364)

ATP-binding cassette transporters mediate differential biosynthesis of glycosphingolipid species [PDF]

Journal of Lipid Research, 2021
The cytosolic-oriented glucosylceramide (GlcCer) synthase is enigmatic, requiring nascent GlcCer translocation to the luminal Golgi membrane to access glycosphingolipid (GSL) anabolic glycosyltransferases. The mechanism by which GlcCer is flipped remains
Monique Budani, Christiane Auray-Blais, Clifford Lingwood   +2 more
doaj   +2 more sources

Predicting ATP-Binding Cassette Transporters Using the Random Forest Method [PDF]

Frontiers in Genetics, 2020
ATP-binding cassette (ABC) proteins play important roles in a wide variety of species. These proteins are involved in absorbing nutrients, exporting toxic substances, and regulating potassium channels, and they contribute to drug resistance in cancer ...
Ruiyan Hou, Ruiyan Hou, Lida Wang, Yi-Jun Wu   +3 more
doaj   +2 more sources

DeepRTCP: Predicting ATP-Binding Cassette Transporters Based on 1-Dimensional Convolutional Network [PDF]

Frontiers in Cell and Developmental Biology, 2021
ATP-binding cassette (ABC) transporters can promote cells to absorb nutrients and excrete harmful substances. It plays a vital role in the transmembrane transport of macromolecules.
Zhaoxi Zhang, Juan Wang, Juan Wang, Jiameng Liu   +3 more
doaj   +2 more sources

Identification and Characterization of ATP-Binding Cassette Transporters in Chlamydomonas reinhardtii [PDF]

Marine Drugs, 2022
Microalgae are promising microorganisms used to produce value-added products or to develop sustainable approaches for environmental remediation.
Xiangyu Li, Xiaolian Li, Xingcai Yang, Chengxiang Lan, Ying Huang, Bin Jia   +5 more
doaj   +2 more sources

Cadmium transport by mammalian ATP-binding cassette transporters [PDF]

BioMetals
AbstractCellular responses to toxic metals depend on metal accessibility to intracellular targets, reaching interaction sites, and the intracellular metal concentration, which is mainly determined by uptake pathways, binding/sequestration and efflux pathways.
Frank Thévenod, Wing-Kee Lee
openaire   +4 more sources

Drug transport mechanism of P-glycoprotein monitored by single molecule fluorescence resonance energy transfer [PDF]

, 2011
In this work we monitor the catalytic mechanism of P-glycoprotein (Pgp) using single-molecule fluorescence resonance energy transfer (FRET). Pgp, a member of the ATP binding cassette family of transport proteins, is found in the plasma membrane of animal
Boersch, Michael, Ernst, Stefan, Verhalen, Brandy, Wilkens, Stephan, Zarrabi, Nawid   +4 more
core   +2 more sources

Expression of some ATP-binding cassette transporters in acute myeloid leukemia [PDF]

Hematology Reports, 2017
Hematopoietic cells express ATP binding cassette (ABC) transporters in relation to different degrees of differentiation. One of the known multidrug resistance mechanisms in acute myeloid leukemia (AML) is the overexpression of efflux pumps belonging to ...
Antonella Maria Salvia, Flavia Cuviello, Sabrina Coluzzi, Roberta Nuccorini, Immacolata Attolico, Sara Pasquina Pascale, Faustino Bisaccia, Michele Pizzuti, Angela Ostuni   +8 more
doaj   +2 more sources

ATP-binding cassette (ABC) transporters in normal and pathological lung [PDF]

Respiratory Research, 2005
Abstract ATP-binding cassette (ABC) transporters are a family of transmembrane proteins that can transport a wide variety of substrates across biological membranes in an energy-dependent manner. Many ABC transporters such as P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1) and breast cancer resistance protein (BCRP) are
van der Deen, M., de Vries, EG, Timens, W., Scheper, R.J., Timmer-Bosscha, H., Postma, D.S.   +5 more
openaire   +6 more sources

Increased expression of ATP‐binding cassette transporters in enfortumab vedotin‐resistant urothelial cancer [PDF]

IJU Case Reports
Introduction In addition to reduced nectin‐4 expression, the upregulation of ATP‐binding cassette transporters has been suggested as a potential mechanism of resistance to enfortumab vedotin.
Mariko Kotono, Toshiki Kijima, Atsuko Takada‐Owada, Naoya Okubo, Ryo Kurashina, Hidetoshi Kokubun, Toshitaka Uematsu, Kohei Takei, Kazuyuki Ishida, Takao Kamai   +9 more
doaj   +2 more sources

ATP-Binding Cassette Transporters in the Clinical Implementation of Pharmacogenetics [PDF]

Journal of Personalized Medicine, 2018
ATP-binding cassette (ABC) transporters are involved in a large number of processes and contribute to various human genetic diseases. Among other functions, ABC proteins are involved in the transport of multiple drugs through cells. Most of the genes coding for these transporters are highly polymorphic and DNA variants in these genes can affect the ...
López-Fernández LA.
openaire   +5 more sources