Preclinical Pharmacokinetic Profile of Topical Ophthalmic and Intravenous Delivery of QLS-101, a Novel ATP-Sensitive Potassium Channel Opening Ocular Hypotensive Agent. [PDF]
J Ocul Pharmacol Ther, 2023 Roy Chowdhury U +9 more
europepmc +1 more source
The structure of a voltage gated potassium channel
, 2010 Voltage gated potassium channels (Kv channels) are tetrameric ion channels, responsible for regulating the potassium component of the membrane potential in a large range of cell types ranging from mammalian excitable cells to bacteria. Attempts have been
Rogers, Nik
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Efeito terapêutico do galato de etila na nocicepção neuropática e induzida por algógenos em camundongos [PDF]
, 2014 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Neurociências, Florianópolis, 2014.O galato de etila (GE) é um composto fenólico encontrado em um grande número de espécies de ...
Coelho, Igor dos Santos
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Control of neurovascular coupling by ATP-sensitive potassium channels
Journal of Cerebral Blood Flow & MetabolismRegional blood flow within the brain is tightly coupled to regional neuronal activity, a process known as neurovascular coupling (NVC). In this study, we demonstrate the striking role of SUR2- and Kir6.1-dependent ATP-sensitive potassium (K ATP ) channels in control of NVC in the sensory ...
Ryan M Bowen +5 more
openaire +2 more sources
Advanced Materials, EarlyView.Template effect and kinetic control enable crystal‐phase engineering of Ru nanocrystals, granting access to either metastable fcc‐Ru or stable hcp‐Ru with distinct surface structures, thermal stabilities, and catalytic behaviors. Moreover, the hcp‐Ru can further serve as an epitaxial template to direct Pd and Rh nanocrystals into the metastable hcp ...
Jianlong He +3 more
wiley +1 more source
Effect of ATP-sensitive Potassium Channel Openers on Intraocular Pressure in Ocular Hypertensive Animal Models. [PDF]
Invest Ophthalmol Vis Sci, 2022 Roy Chowdhury U +6 more
europepmc +1 more source
Phase Engineering of Nanomaterials (PEN): Evolution, Current Challenges, and Future Opportunities
Advanced Materials, EarlyView.This review summarizes the synthesis, phase transition, advanced characterization spanning ex situ to in situ and operando techniques, and diverse applications of phase engineering of nanomaterials (PEN). It further outlines key challenges and future opportunities, such as phase stability, architecture control, and artificial intelligence (AI)‐driven ...
Ye Chen +7 more
wiley +1 more source
Thiolated Polymers in 3D Bioprinting: Control of Gelation
Advanced Materials, EarlyView.Thiolated polymers are established as programmable bioinks for 3D bioprinting, integrating versatile crosslinking chemistries with redox‐responsive control. This work demonstrates how molecular design and external triggers define gelation kinetics, printability windows, and structural fidelity, enabling stable, high‐resolution constructs and advancing ...
Soheil Haddadzadegan +2 more
wiley +1 more source
Photo-Switchable Sulfonylureas Binding to ATP-Sensitive Potassium Channel Reveal the Mechanism of Light-Controlled Insulin Release. [PDF]
J Phys Chem B, 2021 Walczewska-Szewc K, Nowak W.
europepmc +1 more source
, 2012 Two-pore domain potassium channels (K2P) control excitability, stabilize the resting membrane potential below firing threshold, and accelerate repolarisation in different cells.
Szalontai, B. +23 more
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