Results 101 to 110 of about 1,728,775 (305)

Impaired ATP synthase assembly associated with a mutation in the human ATP synthase subunit 6 gene [PDF]

, 2001
Mutations in human mitochondrial DNA are a well recognized cause of disease. A mutation at nucleotide position 8993 of human mitochondrial DNA, located within the gene for ATP synthase subunit 6, is associated with the neurological muscle weakness ...
Attardi, Giuseppe, Henderson, Nadine S., Holti, Ian J., Nijtmans, Leo G. J.   +3 more
core  

ATP consumption of eukaryotic flagella measured at a single-cell level [PDF]

, 2015
The motility of cilia and flagella is driven by thousands of dynein motors that hydrolyze adenosine triphosphate (ATP). Despite decades of genetic, biochemical, structural and biophysical studies, some aspects of ciliary motility remain elusive, such as ...
Chen, Daniel T. N., Dogic, Zvonimir, Fraden, Seth, Heymann, Michael, Nicastro, Daniela   +4 more
core   +2 more sources

A genetically encoded single-wavelength sensor for imaging cytosolic and cell surface ATP

Nature Communications, 2018
Adenosine 5′ triphosphate (ATP) is a universal intracellular energy source and an evolutionarily ancient, ubiquitous extracellular signal in diverse species.
M. A. Lobas, Rongkun Tao, J. Nagai, Mira T. Kronschläger, P. Borden, J. Marvin, L. Looger, B. Khakh   +7 more
semanticscholar   +1 more source

Agmatine suppresses glycolysis via the PI3K/Akt/mTOR/HIF‐1α signaling pathway and improves mitochondrial function in microglia exposed to lipopolysaccharide

BioFactors, Volume 51, Issue 1, January/February 2025.
Agmatine, an endogenous polyamine, changes metabolism of pro‐inflammatory microglia via the PI3K/Akt/mTOR/HIF‐1α signaling pathway. Created with BioRender.com. Abstract Modulating metabolic pathways in activated microglia can alter their phenotype, which is relevant in uncontrolled neuroinflammation as a component of various neurodegenerative diseases.
Katarina Milosevic, Ana Milosevic, Ivana Stevanovic, Anica Zivkovic, Danijela Laketa, Marija M. Janjic, Ivana Bjelobaba, Irena Lavrnja, Danijela Savic   +8 more
wiley   +1 more source

Extracellular ATP released by osteoblasts is a key local inhibitor of bone mineralisation [PDF]

, 2013
Previous studies have shown that exogenous ATP (>1µM) prevents bone formation in vitro by blocking mineralisation of the collagenous matrix. This effect is thought to be mediated via both P2 receptor-dependent pathways and a receptor-independent ...
A Brandao-Burch, A Brandao-Burch, A Gartland, A Hoebertz, BA Evans, CG Bellows, DC Genetos, DC Genetos, E Nakamura, G Burnstock, G Burnstock, G Burnstock, G Burnstock, H Fleisch, H Fleisch, H Zimmermann, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, Isabel R. Orriss, J Ham, JL Ramírez-Zacarías, JP Reyes, KA Buckley, KA Buckley, KA Johnson, L Hessle, Luc Malaval, M Ciciarello, M Romanello, Mark O. R. Hajjawi, Michelle L. Key, MP Abbracchio, MW Pfaffl, N Panupinthu, N Panupinthu, N Wang, N Zippel, RM Rumney, S Shimegi, S Syberg, Timothy R. Arnett, V Ralevic, WB Bowler, WE Razzell, WN Addison   +49 more
core   +3 more sources

Proteome-wide solubility and thermal stability profiling reveals distinct regulatory roles for ATP

Nature Communications, 2018
Adenosine triphosphate (ATP) plays fundamental roles in cellular biochemistry and was recently discovered to function as a biological hydrotrope. Here, we use mass spectrometry to interrogate ATP-mediated regulation of protein thermal stability and ...
Sindhuja Sridharan, N. Kurzawa, Thilo Werner, Ina Günthner, D. Helm, W. Huber, M. Bantscheff, M. Savitski   +7 more
semanticscholar   +1 more source

Blast‐Overpressure Induced Modulation of PARP‐SIRT‐NRF2 Axis in Stress Signaling of Astrocytes and Microglia

Immunity, Inflammation and Disease, Volume 13, Issue 1, January 2025.
In blast injury, ATP levels were elevated from both glycolysis and oxidative phosphorylation (OXPHOS). An increase of ATP by glycolysis is more significant than the OXPHOS source indicating the proinflammation in post‐BOP. Overall, blast‐induced PARP over‐activation impacts the deacetylation activity of sirtuins and the regulation of antioxidant levels
Vijaya Prakash Krishnan Muthaiah, Kathiravan Kaliyappan, Ramkumar Thiayagarajan, Supriya Mahajan, Krishnamoorthy Gunasekaran   +4 more
wiley   +1 more source

ATP-Dependent Persister Formation in Escherichia coli

mBio, 2017
Persisters are dormant variants that form a subpopulation of cells tolerant to antibiotics. Persisters are largely responsible for the recalcitrance of chronic infections to therapy.
Yue Shan, Autumn Brown Gandt, Sarah E. Rowe, Julia P. Deisinger, Brian P. Conlon, K. Lewis   +5 more
semanticscholar   +1 more source

Intracellular Mg2+ concentrations are differentially regulated in the sperm head and mid‐piece in acrosome reaction inducing conditions

The FASEB Journal, Volume 38, Issue 21, 15 November 2024.
Because Mg2+ complexes with ATP, changes in intracellular Mg2+ ([Mg2+]i), monitored with Mag‐520, reflect, in part, ATP levels. Mag‐520 allows the concomitant detection of [Mg2+]i and [Ca2+]i. [Mg2+]i increases under two conditions that reduce ATP: starvation and capacitation. Conversely, nutrient addition to starved sperm decrease Mag‐520 fluorescence.
C. Sánchez‐Cárdenas, J. L. De la Vega‐Beltrán, W. D. Weber, G. Orta, Y. Sánchez‐Guevara, A. Hernández‐Cruz, A. Darszon, P. E. Visconti   +7 more
wiley   +1 more source

Single molecule thermodynamics of ATP synthesis by F$_1$-ATPase

, 2015
F$_\mathrm{o}$F$_1$-ATP synthase is a factory for synthesizing ATP in virtually all cells. Its core machinery is the subcomplex F$_1$-motor (F$_1$-ATPase) and performs the reversible mechanochemical coupling. Isolated F$_1$-motor hydrolyzes ATP, which is
Muneyuki, Eiro, Toyabe, Shoichi
core   +1 more source