Results 61 to 70 of about 3,294 (160)

Identification of Novel Prognostic Biomarkers That are Associated with Immune Microenvironment Based on GABA-Related Molecular Subtypes in Gastric Cancer

Pharmacogenomics and Personalized Medicine, 2023
Beibei Wang, Linlin Huang, Shanliang Ye, Zhongwen Zheng, Shanying Liao Department of Gastroenterology and Hepatology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, People’s Republic of ...
Wang B, Huang L, Ye S, Zheng Z, Liao S
doaj  

Comprehensive Exonic Sequencing of Hemiplegic Migraine-Related Genes in a Cohort of Suspected Probands Identifies Known and Potential Pathogenic Variants

Cells, 2020
Hemiplegic migraine (HM) is a rare migraine disorder with aura subtype including temporary weakness and visual, sensory, and/or speech symptoms. To date, three main genes—CACNA1A, ATP1A2, and SCN1A—have been found to cause HM.
Heidi G. Sutherland, Neven Maksemous, Cassie L. Albury, Omar Ibrahim, Robert A. Smith, Rod A. Lea, Larisa M. Haupt, Bronwyn Jenkins, Benjamin Tsang, Lyn R. Griffiths   +9 more
doaj   +1 more source

ATP1A2 gene mutations are not present in two sisters with basilar-type migraine associated with menses

, 2008
Basilar-type migraine (BM) and hemiplegic migraine are clinically distinct subtypes of migraine with aura, however they do share clinical features and it is possible they may share genetic bases. In recent years, ATP1A2 and other gene mutations have been
Casucci G, Petretta V, Cologno D, Buzzi MG, d'Onofrio F, Bussone G, Esposito T, Gianfrancesco F, Frediani F   +8 more
core   +1 more source

Identification of ASOs targeting Atp1a2 that cause knockdown at the mRNA and protein levels with minimal cytotoxicity.

, 2023
Primary murine wild-type (WT) astrocytes were nucleofected with ctrl or Atp1a2 ASOs at indicated concentrations for 48h (A, B and D) or 72h (C) and were then subjected to downstream analyses. Relative levels of Atp1a2 mRNA in astrocytes nucleofected with
Azad Bonni (221908), Kathleen M. Schoch (17468095), Anthony Verbeck (17468098), Timothy M. Miller (2480425), Hao Chen (5190), Celeste M. Karch (13110199), Abhirami K. Iyer (17468092), Grant Galasso (17468101), Sarah Smith (63540), Anna Oldenborg (17468104)   +9 more
core   +1 more source

Establishment of a transgene-free iPS cell line (SDCHi007-A) from a young patient bearing a ATP1A2 mutation and suffering from Epilepsy

Stem Cell Research
Epilepsy is a chronic neurological disease. Here we describe the generation of induced pluripotent stem cells (iPSCs) from a patient diagnosed as epilepsy caused by ATP1A2 gene mutation.
Hongwei Zhang, Tong Zhang, Yaping Wang, Jianguo Shi, Yao Meng, Qi Zhang, Qingwei Guo, Chunhong Duan   +7 more
doaj   +1 more source

Molecular cloning and characterization of porcine Na⁺/K⁺-ATPase isoforms α1, α2, α3 and the ATP1A3 promoter.

PLoS ONE, 2013
Na⁺/K⁺-ATPase maintains electrochemical gradients of Na⁺ and K⁺ essential for a variety of cellular functions including neuronal activity. The α-subunit of the Na⁺/K⁺-ATPase exists in four different isoforms (α1-α4) encoded by different genes.
Carina Henriksen, Kasper Kjaer-Sorensen, Anja Pernille Einholm, Lone Bruhn Madsen, Jamal Momeni, Christian Bendixen, Claus Oxvig, Bente Vilsen, Knud Larsen   +8 more
doaj   +1 more source

Relaxin‐2: Shaping the Proteomic Landscape of Skeletal Muscle Physiology, Glucose Trafficking, and Mitochondrial Function in Rat

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
Cardioprotective hormone relaxin‐2 showed relevant effects on rat skeletal muscle by altering proteins linked to muscle function, regeneration, differentiation, mitochondrial function, glucose metabolism, and structural integrity and organization. Specifically, relaxin‐2 reduced the expression of 95 proteins, increased 32, and elicited unique proteins ...
Xocas Vázquez‐Abuín, Lucía Gómez‐Cibeira, Javier García‐Seara, Pablo de la Fuente‐López, Carlos Minguito‐Carazo, Susana B. Bravo, Manuel Otero‐Santiago, Oreste Gualillo, José Ramón González‐Juanatey, Francisca Lago, Sandra Feijóo‐Bandín, Alana Aragón‐Herrera   +11 more
wiley   +1 more source

Molecular study of CACNA1A, ATP1A2, and SCN1A genes and its association with the migraine disease in Iraq

Ibom Medical Journal
Background: Migraine is a frequent and debilitating neurological ailment characterized by way of excessive complications and sensory disturbances.
Khudair S, Al Rasheed IA, Ibrahim TK, Saleh TH, Al-Rubaii BA   +4 more
doaj   +1 more source

A Novel ATP1A2 Gene Variant Associated With Pure Sporadic Hemiplegic Migraine Improved After Patent Foramen Ovale Closure: A Case Report

Frontiers in Neurology, 2018
We describe the case of one patient with pure sporadic hemiplegic migraine (SHM) with a novel ATP1A2 gene variant and a large patent foramen ovale (PFO) with atrial septal aneurysm.
Armando Perrotta, Stefano Gambardella, Anna Ambrosini, Maria Grazia Anastasio, Veronica Albano, Francesco Fornai, Francesco Fornai, Francesco Pierelli, Francesco Pierelli   +8 more
doaj   +1 more source

Transcriptional and post-translational changes in the brain of mice deficient in cholesterol removal mediated by cytochrome P450 46A1 (CYP46A1). [PDF]

PLoS ONE, 2017
Cytochrome P450 46A1 (CYP46A1) converts cholesterol to 24-hydroxycholesterol and thereby controls the major pathways of cholesterol removal from the brain.
Natalia Mast, Joseph B Lin, Kyle W Anderson, Ingemar Bjorkhem, Irina A Pikuleva   +4 more
doaj   +1 more source