Results 71 to 80 of about 3,294 (160)

ACP5‐positive macrophages contribute to cerebral oedema and neuroinflammation after traumatic brain injury

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Integrated transcriptomic analyses identified an ACP5‐positive monocyte/macrophage population enriched in the injured brain within 1–3 days after traumatic brain injury (TBI). Pharmacological and genetic targeting of ACP5 attenuated cerebral oedema and neuroinflammation, preserved blood–brain barrier integrity, and improved long‐term cognitive outcomes.
Dang Hanhan, He Kun, Zhang Yulian, Zhang Chuanpeng, Zhang Yunsheng, Wang Zixi, Yang Xu, Chen Pengyu, Zhang Li, Yu Yanbing   +9 more
wiley   +1 more source

Comprehensive analysis of the expression of sodium/potassium-ATPase α subunits and prognosis of ovarian serous cystadenocarcinoma

Cancer Cell International, 2020
Background Ovarian serous cystadenocarcinoma (OSC) is the most common and lethal gynecological cancer in women worldwide; however, biomarkers to diagnose and predict prognosis of OSC remain limited.
Wei Huang, Yongjian Zhang, Ye Xu, Shaoyou Yang, Bing Li, Lan Huang, Ge Lou   +6 more
doaj   +1 more source

A case report of atypical hemiplegic migraine with nonheadache onset in a Chinese child

BMC Neurology, 2021
Background Hemiplegic migraine (HM) is an uncommon subtype of migraine with aura including motor weakness. The core symptoms of HM are headache and motor weakness.
Hui Chen, Xiaolan Sun, Ruiyan Wang, Zhaoshi Yi, Zhixin Huang, Jihua Xie, Xiongying Yu, Yong Chen, Jianmin Zhong   +8 more
doaj   +1 more source

Migraine: Epidemiology, Risk Factors, Pathophysiology, and Treatment

MedComm, Volume 7, Issue 9, September 2026.
Migraine is a highly prevalent, female‐predominant, and disabling brain disorder shaped by genetic susceptibility, hormonal influences, modifiable attack factors, and comorbidity‐related progression. This review integrates current evidence on migraine epidemiology, phase‐specific neurovascular and neuroglial mechanisms, including CGRP signaling and ...
Weiwei Lu, Yuan Zhang, Chen Shi, Yu Tao, Shaoxin Li, Yufang Sun, Fuhai Ji, Dongsheng Jiang, Terrance P. Snutch, Jin Tao   +9 more
wiley   +1 more source

Identification of Novel Fibrosis Modifiers by In Vivo siRNA Silencing

Molecular Therapy: Nucleic Acids, 2017
Fibrotic diseases contribute to 45% of deaths in the industrialized world, and therefore a better understanding of the pathophysiological mechanisms underlying tissue fibrosis is sorely needed.
Elisabeth H. Vollmann, Lizhi Cao, Aldo Amatucci, Taylor Reynolds, Stefan Hamann, Isin Dalkilic-Liddle, Thomas O. Cameron, Markus Hossbach, Kevin J. Kauffman, Faryal F. Mir, Daniel G. Anderson, Tatiana Novobrantseva, Victor Koteliansky, Tatiana Kisseleva, David Brenner, Jeremy Duffield, Linda C. Burkly   +16 more
doaj   +1 more source

Potential Value of Circular RNA circTBC1D4 in Gastrointestinal Stromal Tumors

Journal of Immunology Research, 2022
Aims. To explore the expression of circular RNA (circRNA) in gastrointestinal stromal tumors. Background. Gastrointestinal stromal tumors (GIST) are mainly distributed in the stomach and small intestine.
null Chunyan-Zou, null Yanpeng-He, null Changshun-Xie, null Fulai-Gao, null Xiaoli-Xie, null Xiukun-Chai, null Chenxi-He, null Dongqiang-Zhao   +7 more
doaj   +1 more source

Transitioning from Transcriptomics to Proteomics: Enhancing Mechanistic Accuracy in PBPK Modeling via Absolute Protein Abundances

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 9, September 2026.
ABSTRACT Reliable physiologically based pharmacokinetic (PBPK) modeling depends on tissue‐specific expression profiles that reflect protein activities governing drug disposition. In PK‐Sim, existing expression databases rely on transcriptomics data. However, mRNA levels often exhibit limited correlation with protein abundance, frequently necessitating ...
Chen Ning, Alessandra Pugliano, Maximilian Winter, Keliang Wu, Pieter Annaert   +4 more
wiley   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 468-484, September 2026.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Familial basilar migraine associated with a new mutation in the ATP1A2 gene

, 2005
peer reviewedBasilar migraine (BM), familial hemiplegic migraine (FHM), and sporadic hemiplegic migraine (SHM) are phenotypically similar subtypes of migraine with aura, differentiated only by motor symptoms, which are absent in BM.
AMBROSINI A, NICOLETTI, Ferdinando, Sances, G., SANTORELLI FM, Schoenen, Jean, BUZZI MG, FORTINI D, SCHOENEN J, Nappi, G., SANCESC G, Fortini, D., DI MAMBRO A, Ambrosini, A., Montagna, G., Di Mambro, A., D'ONOFRIO M, Pierelli, F., GRIECO GS, Nicoletti, F., Grieco, G. S., Santorelli, F. M., D'Onofrio, M., Buzzi, M. G., PIERELLI, Francesco, NAPPI, Giuseppe, MONTAGNA G   +25 more
core   +1 more source

A translational multimodal machine‐learning prototype predicting valproate response in epilepsy treatment

Epilepsia, Volume 67, Issue 8, Page 4037-4050, August 2026.
Abstract Objective Epilepsy affects ~1% of the global population and often requires lifelong antiseizure medication (ASM) therapy. Valproic acid (VPA) is a commonly prescribed first‐line ASM, yet only approximately half of patients achieve sustained seizure freedom. Treatment selection remains largely empirical.
Simeon Platte, Afsheen Kumar, Giorgia Guerini, Massimo Pandolfo, Denise Haslinger, Colin B. Josephson, Guillermo Delgado‐García, Navprabhjot Kaur, Michaela‐Pauline Lux, Heiko Stempfle, Chantal Depondt, Reetta Kälviäinen, Felix Rosenow, Sophie von Brauchitsch, Karl Martin Klein, Andreas G. Chiocchetti   +15 more
wiley   +1 more source