Results 91 to 100 of about 9,465 (268)

A Novel Topical Emollient Plus for Canine Atopic Dermatitis: A Clinical Trial Assessing Efficacy and User Acceptance

Veterinary Dermatology, EarlyView.
Background: Canine atopic dermatitis (cAD) is a common, chronic skin condition characterised by epidermal barrier dysfunction, immune dysregulation and cutaneous dysbiosis. While “emollient plus” formulations are widely used in human atopic dermatitis, their role in cAD remains underexplored. Hypothesis/Objectives: To evaluate the clinical efficacy and
Beatriz Fernandes, António Caldeira Mendes, Susana Paula Alves, Vanessa Schmidt, Ana Filipa Bizarro, Marta Pinto, Hugo Pereira, Joana Marto, Ana Mafalda Lourenço   +8 more
wiley   +1 more source

ATP7A-related copper transport diseases—emerging concepts and future trends [PDF]

Nature Reviews Neurology, 2011
This Review summarizes recent advances in understanding copper-transporting ATPase 1 (ATP7A), and examines the neurological phenotypes associated with dysfunction of this protein. Involvement of ATP7A in axonal outgrowth, synapse integrity and neuronal activation underscores the fundamental importance of copper metabolism to neurological function ...
openaire   +2 more sources

Translocation of Platinum Anticancer Drugs by Human Copper ATPases ATP7A and ATP7B [PDF]

Angewandte Chemie International Edition, 2013
AbstractCisplatin, carboplatin, and oxaliplatin are widely used anticancer drugs. Their efficacy is strongly reduced by development of cell resistance. Down‐regulation of CTR1 and up‐regulation of the Cu‐ATPases, ATP7A and ATP7B, have been associated to augmented drug resistance.
TADINI BUONINSEGNI, FRANCESCO, BARTOLOMMEI, GIANLUCA, MONCELLI, MARIA ROSA, G. Inesi, A. Galliani, M. Sinisi, M. Losacco, G. Natile, F. Arnesano   +8 more
openaire   +3 more sources

Zebrafish in the sea of mineral (iron, zinc, and copper) metabolism [PDF]

, 2014
Iron, copper, zinc, and eight other minerals are classified as essential trace elements because they present in minute in vivo quantities and are essential for life.
Fudi Wang, Lu Zhao, Zhidan Xia
core   +1 more source

Randomised, Double‐Blinded, Placebo‐Controlled Challenge Test With Single Food Items in Dogs With Atopic Dermatitis and Adverse Food Reactions

Veterinary Dermatology, EarlyView.
ABSTRACT Background Identification of offending foods in dogs with adverse food reactions is usually based on “deterioration” during open food challenges. Objectives To examine the placebo effect during double‐blinded, placebo‐controlled food challenges using a predefined set of criteria for relapse.
Evi I. Sofou, Elisa Samuel, Svetlina Aleksandrova, Manolis Chatzis, Manolis N. Saridomichelakis   +4 more
wiley   +1 more source

Identification of a Novel Deep Intronic Variant by Whole Genome Sequencing Combined With RNA Sequencing in a Chinese Patient With Menkes Disease

Frontiers in Genetics, 2022
Background: Menkes disease (MD) is a rare X-linked connective tissue disorder of copper metabolism caused by pathogenic variant(s) in ATP7A gene. The aim of the present study is to determine the clinical characteristics and molecular basis of one patient
Xiufang Zhi, Xiufang Zhi, Qi Ai, Qi Ai, Wenchao Sheng, Wenchao Sheng, Yuping Yu, Yuping Yu, Jianbo Shu, Jianbo Shu, Jianbo Shu, Changshun Yu, Xiaoli Yu, Xiaoli Yu, Dong Li, Dong Li, Chunquan Cai, Chunquan Cai, Chunquan Cai   +18 more
doaj   +1 more source

PLEKHA5, PLEKHA6 and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis

bioRxiv, 2021
Copper homeostasis is crucial for cellular physiology and development, and its dysregulation leads to disease. The Menkes ATPase ATP7A plays a key role in copper efflux, by trafficking from the Golgi to the plasma membrane upon cell exposure to elevated ...
Sophie Sluysmans, Isabelle Méan, Tong Xiao, Amina Boukhatemi, F. Ferreira, Lionel Jond, Christopher J. Chang, S. Citi   +7 more
semanticscholar   +1 more source

Assessing D‐Squame as a Minimally Invasive Technique to Evaluate the Cutaneous Immune Response mRNA in a Dog Model of Canine Atopic Dermatitis

Veterinary Dermatology, EarlyView.
ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon, Marion Mosca, Nadège Milhau, Mélanie Legain, Adrien Idée, Didier Pin   +5 more
wiley   +1 more source

Bioavailable Trace Metals in Neurological Diseases [PDF]

, 2016
Medical treatment in Wilson’s disease includes chelators (d-penicillamine and trientine) or zinc salts that have to be maintain all the lifelong. This pharmacological treatment is categorised into two phases; the first being a de-coppering phase and the ...
A Ahuja, A Czlonkowska, A Donsante, A Groger, A Ignjatovic, AC Crespo, AD Monnot, AJ Coffey, Aurélia Poujois, B Yao, BE Needham, BS Choi, BX Wong, BX Wong, C Camaschella, C Guo, C Langkammer, C Quintana, C Veyrat-Durebex, CA Shaw, Caroline Moreau, D Berg, D Devos, D Martinelli, David Devos, DT Dexter, E Brodkin, E Milusheva, EJ Martinez-Finley, F Woimant, France Woimant, G Abbruzzese, G Cairo, G Cossu, G Du, G Zorzi, G Zorzi, GJ Brewer, H Xu, H Zischka, I Bremner, J Lhermitte, J Lotharius, JA Duce, James A. Duce, Jean-Christophe Devedjian, JL Roybal, JM Trocello, JM Trocello, JN Guzman, JR Connor, JR Prohaska, JS Kauwe, JT Rogers, JY Kwan, K Ikeda, KH Weiss, KH Weiss, KJ Klos, L Wan, L Wan, L Zecca, LI Wallis, MM Zeineh, N Krebs, O Bandmann, O Guillaud, O Kakhlon, P Delangle, P Huppke, P Lei, P Peran, Pascal Chaine, PK Sethi, Q Wang, R Chamberlain, RC McCarthy, RE Fleming, S Ayton, S Ayton, S Balkhi El, S Levi, S Lutsenko, S Przedborski, SG Kaler, SG Kaler, SY Jeong, T Ducic, T Haraguchi, T Moos, T Teodoro, TA Rouault, TA Rouault, TR Guilarte, TR Halfdanarson, TW Clarkson, U Merle, V Medici, XW Su, Y Nadjar, YS Sohn, ZI Cabantchik   +101 more
core   +1 more source

FGF13 enhances resistance to platinum drugs by regulating hCTR1 and ATP7A via a microtubule‐stabilizing effect

Cancer Science, 2021
Platinum‐based regimens are the most widely used chemotherapy regimens, but cancer cells often develop resistance, which impedes therapy outcome for patients.
Hang Yu, Han-dong Wang, Anran Qie, Jiaqi Wang, Yueping Liu, G. Gu, Jing Yang, Hanqiu Zhang, Wensen Pan, Z. Tian, Chuan Wang   +10 more
semanticscholar   +1 more source