Results 1 to 10 of about 112,456 (244)
Regulatory roles of copper metabolism and cuproptosis in human cancers [PDF]
Frontiers in Oncology, 2023 Copper is an essential micronutrient for human body and plays a vital role in various biological processes including cellular respiration and free radical detoxification.
Zhe Wang +8 more
doaj +4 more sources
IGFBP2 from a novel copper metabolism-associated biomarker promoted glioma progression and response to immunotherapy [PDF]
Frontiers in Immunology, 2023 IntroductionCopper metabolism encompasses all cellular metabolic processes involving copper ions and plays a significant role in the pathogenesis of diseases, including cancer.
Qisheng Luo +12 more
doaj +4 more sources
Targeting copper metabolism: a promising strategy for cancer treatment [PDF]
Frontiers in Pharmacology, 2023 Copper is an essential micronutrient that plays a critical role in many physiological processes. However, excessive copper accumulation in cancer cells has been linked to tumor growth and metastasis.
Ruimin Kong, Guojuan Sun
doaj +4 more sources
Copper Metabolism of Astrocytes [PDF]
Frontiers in Aging Neuroscience, 2013 This short review will summarize the current knowledge on the uptake, storage and export of copper ions by astrocytes and will address the potential roles of astrocytes in copper homeostasis in the normal and diseased brain.
Ralf eDringen +2 more
doaj +5 more sources
Copper metabolism and hepatocellular carcinoma: current insights [PDF]
Frontiers in Oncology, 2023 Copper is an essential trace element that acts as a cofactor in various enzyme active sites in the human body. It participates in numerous life activities, including lipid metabolism, energy metabolism, and neurotransmitter synthesis.
Cheng Zhou +6 more
doaj +2 more sources
The Features of Copper Metabolism in the Rat Liver during Development. [PDF]
PLoS ONE, 2015 Strong interest in copper homeostasis is due to the fact that copper is simultaneously a catalytic co-factor of the vital enzymes, a participant in signaling, and a toxic agent provoking oxidative stress.
Yulia A Zatulovskaia +2 more
doaj +3 more sources
Identification of copper metabolism-related markers in Parkinson’s disease [PDF]
Annals of MedicineObjectives This study aimed to identify key genes related to copper metabolism in Parkinson’s disease (PD), providing insight into their roles in disease progression.Methods Using bioinformatic analyses, the study identified hub genes related to copper ...
Jie Lin +7 more
doaj +2 more sources
Frontiers in Endocrinology, 2023 BackgroundOvarian cancer (OC) is one of the most common and most malignant gynecological malignancies in gynecology. On the other hand, dysregulation of copper metabolism (CM) is closely associated with tumourigenesis and progression.
Songyun Zhao +8 more
doaj +3 more sources
COMMD3 Regulates Copper Metabolism via the ATOX1-ATP7A-LOX Axis to Promote Multiple Myeloma Progression [PDF]
BiomedicinesBackground: Multiple myeloma (MM) is a hematologic malignancy characterized by the clonal proliferation of plasma cells, with extramedullary myeloma (EMM) being an aggressive form involving malignant infiltration beyond the bone marrow. Copper metabolism
Yajun Wang +7 more
doaj +2 more sources
Pharmaceutics, 2023 The link between copper metabolism and tumor progression motivated us to use copper chelators for suppression of tumor growth. We assume that silver nanoparticles (AgNPs) can be used for lowering bioavailable copper.
Daria N. Magazenkova +8 more
doaj +3 more sources