Results 1 to 10 of about 1,610,695 (235)

Copper Metabolism of Astrocytes

Frontiers in Aging Neuroscience, 2013
This short review will summarize the current knowledge on the uptake, storage and export of copper ions by astrocytes and will address the potential roles of astrocytes in copper homeostasis in the normal and diseased brain.
Ralf eDringen, Ivo F Scheiber, Julian FB Mercer   +2 more
doaj   +2 more sources

Fetal Brain-directed AAV Gene Therapy Results in Rapid, Robust, and Persistent Transduction of Mouse Choroid Plexus Epithelia

Molecular Therapy: Nucleic Acids, 2013
Fetal brain-directed gene addition represents an under-appreciated tool for investigating novel therapeutic approaches in animal models of central nervous system diseases with early prenatal onset.
Marie Reine Haddad, Anthony Donsante, Patricia Zerfas, Stephen G Kaler   +3 more
doaj   +1 more source

Copper metabolism-related signature for prognosis prediction and MMP13 served as malignant factor for breast cancer. [PDF]

Heliyon
Han C, Feng Z, Wang Y, Hu M, Xu S, Jiang F, Han Y, Liu Z, Li Y.   +8 more
europepmc   +2 more sources

Bioinformatics-Based Analysis of Key Genes in Steroid-Induced Osteonecrosis of the Femoral Head That Are Associated with Copper Metabolism

Biomedicines, 2023
Osteonecrosis of the femoral head (ONFH) is a common disabling disease. Copper has positive effects on cells that regulate bone metabolism. However, the relationship between copper metabolism (CM) and steroid-induced ONFH (SONFH) remains unclear.
Baochuang Qi, Chuan Li, Xingbo Cai, Luqiao Pu, Minzheng Guo, Zhifang Tang, Pengfei Bu, Yongqing Xu   +7 more
doaj   +1 more source

Copper signalling: causes and consequences

Cell Communication and Signaling, 2018
Copper-containing enzymes perform fundamental functions by activating dioxygen (O2) and therefore allowing chemical energy-transfer for aerobic metabolism.
Julianna Kardos, László Héja, Ágnes Simon, István Jablonkai, Richard Kovács, Katalin Jemnitz   +5 more
doaj   +1 more source

Copper metabolism patterns and tumor microenvironment characterization in colon adenocarcinoma

Frontiers in Oncology, 2022
Copper participates in biological processes such as oxygen metabolism and iron uptake, and is a key factor in immune regulation. Based on the transcription data, mutation data and clinical data of colon adenocarcinoma (COAD) patients from The Cancer ...
Jianwei Lin, Bixian Luo, Xinbo Yu, Zheyu Yang, Mingliang Wang, Mingliang Wang, Wei Cai   +6 more
doaj   +1 more source

Copper-related genes predict prognosis and characteristics of breast cancer

Frontiers in Immunology, 2023
BackgroundThe role of copper in cancer treatment is multifaceted, with copper homeostasis-related genes associated with both breast cancer prognosis and chemotherapy resistance. Interestingly, both elimination and overload of copper have been reported to
Yi Liu, Jiandong Wang, Mengxi Jiang, Mengxi Jiang   +3 more
doaj   +1 more source

Disrupting Cu trafficking as a potential therapy for cancer

Frontiers in Molecular Biosciences, 2022
Copper ions play a crucial role in various cellular biological processes. However, these copper ions can also lead to toxicity when their concentration is not controlled by a sophisticated copper-trafficking system. Copper dys-homeostasis has been linked
Zena Qasem, Matic Pavlin, Matic Pavlin, Ida Ritacco, Ida Ritacco, Matan Y. Avivi, Shelly Meron, Melanie Hirsch, Yulia Shenberger, Lada Gevorkyan-Airapetov, Alessandra Magistrato, Sharon Ruthstein   +11 more
doaj   +1 more source

Abnormal Copper Homeostasis: Mechanisms and Roles in Neurodegeneration

Toxics, 2014
As a cofactor of proteins and enzymes involved in critical molecular pathways in mammals and low eukaryotes, copper is a transition metal essential for life.
Mario Manto
doaj   +1 more source

Copper in cancer: from limiting nutrient to therapeutic target

Frontiers in Oncology, 2023
As an essential nutrient, copper’s redox properties are both beneficial and toxic to cells. Therefore, leveraging the characteristics of copper-dependent diseases or using copper toxicity to treat copper-sensitive diseases may offer new strategies for ...
Xiaolong Tang, Xiaolong Tang, Zaihua Yan, Zaihua Yan, Yandong Miao, Wuhua Ha, Zheng Li, Lixia Yang, Denghai Mi, Denghai Mi   +9 more
doaj   +1 more source