Results 21 to 30 of about 1,610,695 (235)
COMMD3 Regulates Copper Metabolism via the ATOX1-ATP7A-LOX Axis to Promote Multiple Myeloma Progression [PDF]
BiomedicinesBackground: Multiple myeloma (MM) is a hematologic malignancy characterized by the clonal proliferation of plasma cells, with extramedullary myeloma (EMM) being an aggressive form involving malignant infiltration beyond the bone marrow. Copper metabolism
Yajun Wang +7 more
doaj +2 more sources
Identification of copper metabolism-related markers in Parkinson’s disease [PDF]
Annals of MedicineObjectives This study aimed to identify key genes related to copper metabolism in Parkinson’s disease (PD), providing insight into their roles in disease progression.Methods Using bioinformatic analyses, the study identified hub genes related to copper ...
Jie Lin +7 more
doaj +2 more sources
HeliyonCopper, a vital trace element, orchestrates diverse cellular processes ranging from energy production to antioxidant defense and angiogenesis. Copper metabolism and cuproptosis are closely linked in the context of human diseases, with a particular focus ...
K.M. Abdullah +7 more
doaj +3 more sources
Targeting copper metabolism: a promising strategy for cancer treatment [PDF]
Frontiers in Pharmacology, 2023 Copper is an essential micronutrient that plays a critical role in many physiological processes. However, excessive copper accumulation in cancer cells has been linked to tumor growth and metastasis.
Ruimin Kong, Guojuan Sun
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Pharmaceutics, 2023 The link between copper metabolism and tumor progression motivated us to use copper chelators for suppression of tumor growth. We assume that silver nanoparticles (AgNPs) can be used for lowering bioavailable copper.
Daria N. Magazenkova +8 more
doaj +3 more sources
α-Lipoic acid: a potential regulator of copper metabolism in Alzheimer’s disease [PDF]
Frontiers in Molecular BiosciencesAlzheimer’s disease (AD) is characterized by classic hallmarks such as amyloid plaques and neurofibrillary tangles, however, intensive research has broadened its scope to explore additional underlying mechanisms. Notably, disruptions in metal homeostasis,
Sigrid Kirss +5 more
doaj +2 more sources
Disorders of Copper Metabolism in Children—A Problem too Rarely Recognized [PDF]
MetabolitesCopper plays an important role in metabolic processes. Both deficiency and excess of this element have a negative effect and lead to pathological conditions. Copper is a cofactor of many enzymatic reactions.
Sabina Więcek, Justyna Paprocka
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Zebrafish mutants calamity and catastrophe define critical pathways of gene-nutrient interactions in developmental copper metabolism. [PDF]
PLoS Genetics, 2008 Nutrient availability is an important environmental variable during development that has significant effects on the metabolism, health, and viability of an organism.
Erik C Madsen, Jonathan D Gitlin
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Copper metabolism in cell death and autophagy. [PDF]
Autophagy, 2023 Xue Q +5 more
europepmc +2 more sources
Metallothioneins and copper metabolism are candidate therapeutic targets in Huntington’s disease [PDF]
, 2010 HD (Huntington's disease) is caused by a polyQ (polyglutamine) expansion in the huntingtin protein, which leads to protein misfolding and aggregation of this protein. Abnormal copper accumulation in the HD brain was first reported more than 15 years ago.
Giorgini, Flaviano +18 more
core +4 more sources