Results 21 to 30 of about 112,456 (244)
Biomedicines, 2023 Osteonecrosis of the femoral head (ONFH) is a common disabling disease. Copper has positive effects on cells that regulate bone metabolism. However, the relationship between copper metabolism (CM) and steroid-induced ONFH (SONFH) remains unclear.
Baochuang Qi +7 more
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Molecular Therapy: Nucleic Acids, 2013 Fetal brain-directed gene addition represents an under-appreciated tool for investigating novel therapeutic approaches in animal models of central nervous system diseases with early prenatal onset.
Marie Reine Haddad +3 more
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Copper metabolism patterns and tumor microenvironment characterization in colon adenocarcinoma
Frontiers in Oncology, 2022 Copper participates in biological processes such as oxygen metabolism and iron uptake, and is a key factor in immune regulation. Based on the transcription data, mutation data and clinical data of colon adenocarcinoma (COAD) patients from The Cancer ...
Jianwei Lin +6 more
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Copper-related genes predict prognosis and characteristics of breast cancer
Frontiers in Immunology, 2023 BackgroundThe role of copper in cancer treatment is multifaceted, with copper homeostasis-related genes associated with both breast cancer prognosis and chemotherapy resistance. Interestingly, both elimination and overload of copper have been reported to
Yi Liu +3 more
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Disrupting Cu trafficking as a potential therapy for cancer
Frontiers in Molecular Biosciences, 2022 Copper ions play a crucial role in various cellular biological processes. However, these copper ions can also lead to toxicity when their concentration is not controlled by a sophisticated copper-trafficking system. Copper dys-homeostasis has been linked
Zena Qasem +11 more
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Copper signalling: causes and consequences
Cell Communication and Signaling, 2018 Copper-containing enzymes perform fundamental functions by activating dioxygen (O2) and therefore allowing chemical energy-transfer for aerobic metabolism.
Julianna Kardos +5 more
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Recent Advances in Copper-Based Organic Complexes and Nanoparticles for Tumor Theranostics
Molecules, 2022 Treatment of drug-resistant forms of cancer requires consideration of their hallmark features, such as abnormal cell death mechanisms or mutations in drug-responding molecular pathways.
Sergey Tsymbal +7 more
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Frontiers in Immunology, 2023 Copper, a transition metal, serves as an essential co-factor in numerous enzymatic active sites and constitutes a vital trace element in the human body, participating in crucial life-sustaining activities such as energy metabolism, antioxidation ...
Lei Gao, Anqi Zhang
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Copper Metabolism. XII. Influence of Manganese on Metabolism of Copper.
Experimental Biology and Medicine, 1954 Summary1. Administration of large amounts of manganese to rats was associated with an increase in the concentration of copper in plasma and brain, a decrease in the urinary excretion of copper, a decrease in the concentration of copper in the kidneys, no alteration in the concentration of copper in the liver, and microcytic, hypochromic anemia.
C J, GUBLER +4 more
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Copper in cancer: from limiting nutrient to therapeutic target
Frontiers in Oncology, 2023 As an essential nutrient, copper’s redox properties are both beneficial and toxic to cells. Therefore, leveraging the characteristics of copper-dependent diseases or using copper toxicity to treat copper-sensitive diseases may offer new strategies for ...
Xiaolong Tang +9 more
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