Copper metabolism in hepatocellular carcinoma: from molecular mechanisms to therapeutic opportunities [PDF]
Frontiers in Molecular BiosciencesCopper is a vital trace metal that facilitates cell proliferation, angiogenesis, and tumour spread. The liver is essential for copper metabolism, hence regulating copper levels is crucial for hepatic health.
Ziling Pang
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Copper metabolism and hepatocellular carcinoma: current insights [PDF]
Frontiers in Oncology, 2023 Copper is an essential trace element that acts as a cofactor in various enzyme active sites in the human body. It participates in numerous life activities, including lipid metabolism, energy metabolism, and neurotransmitter synthesis.
Cheng Zhou +6 more
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Regulatory roles of copper metabolism and cuproptosis in human cancers
Frontiers in Oncology, 2023 Copper is an essential micronutrient for human body and plays a vital role in various biological processes including cellular respiration and free radical detoxification.
Zhe Wang +8 more
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Metabolism of copper and possibilities for its regulation [PDF]
Proceedings of the Estonian Academy of Sciences, 2023 Copper is an indispensable biometal participating as a redox catalyst in many important biochemical processes. However, if uncontrolled, copper ions induce the formation of reactive oxygen species and become toxic.
Peep Palumaa
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Frontiers in Immunology, 2023 IntroductionCopper metabolism encompasses all cellular metabolic processes involving copper ions and plays a significant role in the pathogenesis of diseases, including cancer.
Qisheng Luo +12 more
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Single-Cell Transcriptomic Analysis Reveals Copper Metabolism Heterogeneity and Phenotypic Remodeling in Vaginal Anterior Wall Stromal Cells in Pelvic Organ Prolapse [PDF]
BiologyPelvic organ prolapse (POP) is a common disease characterized by disordered extracellular matrix (ECM) remodeling of pelvic support tissues. Copper dysregulation drives fibrosis in multiple diseases, whereas its function in POP remains unclear.
Zhi Wang +7 more
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Adipose-derived mesenchymal stem cell exosomes ameliorate copper metabolism dysregulation and reduce cuproptosis caused by liver IRI [PDF]
Frontiers in Veterinary ScienceIntroductionHepatic ischemia reperfusion injury is an important pathological factor leading to complications after hepatectomy and transplantation.
Lei Cao +15 more
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The Features of Copper Metabolism in the Rat Liver during Development. [PDF]
PLoS ONE, 2015 Strong interest in copper homeostasis is due to the fact that copper is simultaneously a catalytic co-factor of the vital enzymes, a participant in signaling, and a toxic agent provoking oxidative stress.
Yulia A Zatulovskaia +2 more
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The impact of copper on bone metabolism
Journal of Orthopaedic TranslationCopper is an essential trace element for the human body. Abnormalities in copper metabolism can lead to bone defects, mainly by directly affecting the viability of osteoblasts and osteoclasts and their bone remodeling function, or indirectly regulating ...
Zihan Zhang +3 more
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Copper Metabolism and Cuproptosis in Ovarian Cancer
Clinical and Experimental Obstetrics & GynecologyObjectives: This review provides a comprehensive analysis of copper metabolism and cuproptosis in ovarian cancer (OC), evaluating therapeutic strategies targeting copper to improve clinical outcomes.
Yuhong Xu +4 more
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