Results 1 to 10 of about 1,007,592 (239)

Role of the P-Type ATPases, ATP7A and ATP7B in brain copper homeostasis [PDF]

open access: yesFrontiers in Aging Neuroscience, 2013
Over the past two decades there have been significant advances in our understanding of copper homeostasis and the pathological consequences of copper dysregulation.
Jonathon eTelianidis   +3 more
doaj   +2 more sources

Crossroads between membrane trafficking machinery and copper homeostasis in the nerve system

open access: yesOpen Biology, 2021
Imbalanced copper homeostasis and perturbation of membrane trafficking are two common symptoms that have been associated with the pathogenesis of neurodegenerative and neurodevelopmental diseases.
Meng-Hsuan Wen   +4 more
doaj   +1 more source

Evidence of Homeostatic Regulation in Mycobacterium avium Subspecies paratuberculosis as an Adaptive Response to Copper Stress

open access: yesMicroorganisms, 2023
Background: Bacteria are capable of responding to various stressors, something which has been essential for their adaptation, evolution, and colonization of a wide range of environments.
Carlos Tejeda   +5 more
doaj   +1 more source

The Role of Sulfur in Agronomic Biofortification with Essential Micronutrients

open access: yesPlants, 2022
Sulfur (S) is an essential macronutrient for plants, being necessary for their growth and metabolism and exhibiting diverse roles throughout their life cycles. Inside the plant body, S is present either in one of its inorganic forms or incorporated in an
Styliani N. Chorianopoulou   +1 more
doaj   +1 more source

The mechanism of copper homeostasis and its role in disease

open access: yesiLABMED, 2023
Copper (Cuprum) is an essential trace metal indispensable for the function of numerous enzymatic molecules implicated in cellular metabolism. Emerging evidence has demonstrated the role of copper in angiogenesis and cellular signaling.
Yunhui Li   +3 more
doaj   +1 more source

Relationships Between Copper-Related Proteomes and Lifestyles in β Proteobacteria

open access: yesFrontiers in Microbiology, 2019
Copper is an essential transition metal whose redox properties are used for a variety of enzymatic oxido-reductions and in electron transfer chains. It is also toxic to living beings, and therefore its cellular concentration must be strictly controlled ...
Rudy Antoine   +3 more
doaj   +1 more source

Research Progress on the Role of Copper Homeostasis Regulation Mechanism in Cognition Disorder [PDF]

open access: yesZhongguo quanke yixue
Cognitive impairment is often manifested as a series of brain function deficits such as learning, memory, intellectual, emotional, and executive deficits. It often occurs in neurological disorders, aging, and the postoperative period.
ZHOU Lianpeng, LI Weifeng, DONG Xingang, WANG Xiaoyuan
doaj   +1 more source

Copper Homeostasis in Aspergillus fumigatus: Opportunities for Therapeutic Development

open access: yesFrontiers in Microbiology, 2019
Aspergillus fumigatus can cause severe invasive aspergillosis in immunocompromised individuals. Copper, an essential but potentially toxic trace element for A. fumigatus, plays a critical role at the host-pathogen axis during infection.
Jinxing Song, Rongpeng Li, Jihong Jiang
doaj   +1 more source

Liver-specific Commd1 knockout mice are susceptible to hepatic copper accumulation. [PDF]

open access: yesPLoS ONE, 2011
Canine copper toxicosis is an autosomal recessive disorder characterized by hepatic copper accumulation resulting in liver fibrosis and eventually cirrhosis.
Willianne I M Vonk   +9 more
doaj   +1 more source

Copper-Based Antibiotic Strategies: Exploring Applications in the Hospital Setting and the Targeting of Cu Regulatory Pathways and Current Drug Design Trends

open access: yesInorganics, 2023
Classical antibacterial drugs were designed to target specific bacterial properties distinct from host human cells to maximize potency and selectivity. These designs were quite effective as they could be easily derivatized to bear next-generation drugs ...
Aixa M. Orta-Rivera   +13 more
doaj   +1 more source

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