Results 21 to 30 of about 1,007,592 (239)

Disruption of NF‐κB‐Mediated Copper Homeostasis Sensitizes Breast Cancer to Cuproptosis [PDF]

Advanced Science
Copper plays a key role in inflammation and recent tumorigenesis. However, copper homeostasis and its role in cuproplasia and cuproptosis for cancer intervention remain incompletely explored. Here, it is unveiled that copper enhances the NF‐κB pathway by
Xiaomei Zhang, Yaqing Su, Weixiong Yang, Zimin Song, Zicheng Sun, Xueji Wu, Jianwen Chen, Bing Gao, Zekang Wang, Lei Wang, Qiwei Jiang, Lang Bu, Jingting Li, Ying Lin, Wei Xie, Jie Li, Jianping Guo   +16 more
doaj   +2 more sources

Age-related cellular copper dynamics in the fungal ageing model Podospora anserina and in ageing human fibroblasts [PDF]

, 2009
In previous investigations an impact of cellular copper homeostasis on ageing of the ascomycete Podospora anserina has been demonstrated. Here we provide new data indicating that mitochondria play a major role in this process.
Rittmeyer, Claudia, Olivier Toussaint, Scheckhuber, Christian Q., Ricardo Gredilla, Bernd O Kolbesen, Heinz D, Boilan, Emmanuelle, Claudia Rittmeyer, Gredilla, Ricardo, Christian Q. Scheckhuber, Emmanuelle Boilan, Heinz D. Osiewacz, Debacq-Chainiaux, Florence, Osiewacz, Heinz D., Scheckhuber, Christian Quintus, Christian Q Scheckhuber, Florence Debacq-Chainiaux, Toussaint, Olivier, Kolbesen, Bernd O., Karin Luce, Bernd O. Kolbesen, Heinz D Osiewacz, Grief, Jürgen, Florence Debacq, Jürgen Grief, Luce, Karin, Rittmeyer Claudia, Gredilla Ricardo, Boilan Emmanuelle, Scheckhuber Christian Q., Grief Jürgen, Luce Karin, Kolbesen Bernd O., Debacq-Chainiaux Florence, Osiewacz Heinz D., Toussaint Olivier   +35 more
core   +2 more sources

A differential genome-wide transcriptome analysis : impact of cellular copper on complex biological processes like aging and development [PDF]

, 2012
The regulation of cellular copper homeostasis is crucial in biology. Impairments lead to severe dysfunctions and are known to affect aging and development.
Servos, Jörg, Hamann, Andrea, Andrea Hamann, Jörg Servos, Heinz D. Osiewacz (120841), Osiewacz, Heinz D., Andrea Hamann (120836), Carolin Grimm (120839), Grimm, Carolin, Jörg Servos (120834), Heinz D Osiewacz, Carolin Grimm, Osiewacz Heinz D., Servos Jörg, Grimm Carolin, Hamann Andrea   +15 more
core   +2 more sources

Copper-Based MetalOrganic Framework Overcomes Cancer Chemoresistance through Systemically Disrupting Dynamically Balanced Cellular Redox Homeostasis

, 2022
Chemodrug resistance is a major reason accounting for tumor recurrence. Given the mechanistic complexity of chemodrug resistance, molecular inhibitors and targeting drugs often fail to eliminate drug-resistant cancer cells, and sometimes even promote ...
Lin Shi, Cheng Zhou, Zheng Wang (25883), Jia Liu (41593), Yanni Cheng (9682330), Meizhen Zou, Lifang Zhang (130786), Ye Yuan, Lin Shi (65217), Lin Wang (11986), Ye Yuan (531126), Zhongyin Chen (8817413), Chundong Yao, Guobin Wang, Meizhen Zou (12120352), Cheng Zhou (307152), Chundong Yao (12120349), Jia Liu, Lin Wang, Daan Fu (9682327), Zheng Wang, Mingyi Li, Lifang Zhang, Guobin Wang (322861), Daan Fu, Yang Wang (5921), Yanni Cheng, Zhongyin Chen, Yang Wang, Mingyi Li (443593)   +29 more
core   +1 more source

Copper homeostasis in Enterococcus hirae [PDF]

, 2003
Copper is an essential component of life because of its convenient redox potential of 200–800 mV when bound to protein. Extensive insight into copper homeostasis has only emerged in the last decade and Enterococcus hirae has served as a paradigm for many
Stoyanov, Jivko V., Solioz, Marc, Stoyanov JV, Solioz M   +3 more
core   +2 more sources

Host-Imposed Copper Poisoning Impacts Fungal Micronutrient Acquisition during Systemic Candida albicans Infections.

PLoS ONE, 2016
Nutritional immunity is a process whereby an infected host manipulates essential micronutrients to defend against an invading pathogen. We reveal a dynamic aspect of nutritional immunity during infection that involves copper assimilation.
Joanna Mackie, Edina K Szabo, Dagmar S Urgast, Elizabeth R Ballou, Delma S Childers, Donna M MacCallum, Joerg Feldmann, Alistair J P Brown   +7 more
doaj   +1 more source

A co-opted endogenous retroviral envelope promotes cell survival by controlling CTR1-mediated copper transport and homeostasis

Cell Reports, 2023
Summary: Copper is a critical element for eukaryotic life involved in numerous cellular functions, including redox balance, but is toxic in excess. Therefore, tight regulation of copper acquisition and homeostasis is essential for cell physiology and ...
Sandrine Tury, Lise Chauveau, Arnaud Lecante, Valérie Courgnaud, Jean-Luc Battini   +4 more
doaj   +1 more source

Copper Homeostasis in S. meliloti

, 2013
The Sinorhizobium meliloti genome encodes five Cu+-ATPases that aid in detoxification and regulate copper homeostasis via the efflux of copper from the cytoplasm to the periplasmic space.
Nemet-Sousa, Jacquelyn Marie
core   +3 more sources

Deregulated High Affinity Copper Transport Alters Iron Homeostasis in Arabidopsis

Frontiers in Plant Science, 2020
The present work describes the effects on iron homeostasis when copper transport was deregulated in Arabidopsis thaliana by overexpressing high affinity copper transporters COPT1 and COPT3 (COPTOE).
Ana Perea-García, Amparo Andrés-Bordería, Francisco Vera-Sirera, Miguel Angel Pérez-Amador, Sergi Puig, Lola Peñarrubia   +5 more
doaj   +1 more source

Copper homeostasis in the human body.

, 2022
Under copper homeostatic conditions, the amount of copper that enters an adult human body is the same that leaves the body. Because an average diet provides more copper than the minimum amount required (top), most dietary copper is excreted through feces
Francesca Focarelli (13132139), Andrea Giachino (13132142), Kevin John Waldron (13132145)   +2 more
core   +1 more source