Results 31 to 40 of about 1,007,592 (239)

Copper and Anesthesia: Clinical Relevance and Management of Copper Related Disorders

Anesthesiology Research and Practice, 2013
Recent research has implicated abnormal copper homeostasis in the underlying pathophysiology of several clinically important disorders, some of which may be encountered by the anesthetist in daily clinical practice.
Adrian Langley, Charles T. Dameron
doaj   +1 more source

Impairment of interrelated iron- and copper homeostatic mechanisms in brain contributes to the pathogenesis of neurodegenerative disorders

Frontiers in Pharmacology, 2012
Iron and copper are important co-factors for a number of enzymes in the brain, including enzymes involved in neurotransmitter synthesis and myelin formation. Both shortage and an excess of iron or copper will affect the brain.
Tina eSkjørringe, Tina eSkjørringe, Lisbeth Birk Møller, Torben eMoos   +3 more
doaj   +1 more source

COMMD1 in Copper Homeostasis

, 2018
Diverse animal models for copper overload disorders like the human Wilson disease have been described. Unraveling the genetic cause of hepatic copper toxicosis in Bedlington terriers revealed COpper Metabolism Murr1 Domain (COMMD)1 as a novel gene in ...
van de Sluis, Albertus, Van De Sluis, Bart; id_orcid, Bart van de Sluis   +2 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Iron and copper homeostasis in Staphylococcus aureus

, 2009
Staphylococcus aureus is a pathogenic bacterium that causes a wide spectrum of human diseases and is a leading cause of nosocomial infection in the UK. Metal homeostasis is an important aspect of bacterial biology as transition metals such as copper and ...
Jonathan Peter Baker (7597934)
core   +4 more sources

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Dextran-Catechin inhibits angiogenesis by disrupting copper homeostasis in endothelial cells

Scientific Reports, 2017
Formation of blood vessels, or angiogenesis, is crucial to cancer progression. Thus, inhibiting angiogenesis can limit the growth and spread of tumors. The natural polyphenol catechin has moderate anti-tumor activity and interacts with copper, which is ...
Eugene M. H. Yee, Miriam B. Brandl, Eddy Pasquier, Giuseppe Cirillo, Kathleen Kimpton, Maria Kavallaris, Naresh Kumar, Orazio Vittorio   +7 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Investigation of iron metabolism in mice expressing a mutant Menke's copper transporting ATPase (Atp7a) protein with diminished activity (Brindled; Mo (Br) (/y) ).

PLoS ONE, 2013
During iron deficiency, perturbations in copper homeostasis have frequently been documented. Previous studies in iron-deprived rats demonstrated that enterocyte and hepatic copper levels increase and a copper transporter (the Menkes Copper ATPase; Atp7a)
Sukru Gulec, James F Collins
doaj   +1 more source

Fusogenic RNA Nanomodules for Fusion‐Mediated and Multiplexed siRNA Delivery

Advanced Functional Materials, Volume 36, Issue 86, 26 October 2026.
A fusogenic lipid‐layered RNA nanomodules (L‐CRAMs) enable high‐capacity and long‐lasting siRNA delivery through membrane fusion. These nanomodules carry exceptionally large siRNA payloads, avoid conventional endosomal uptake, and release multiple functional siRNAs through Dicer‐mediated processing.
Sunghyun Moon, Iksoo Jang, Taehyeon Kim, Nayoung Yoon, Kyuha Yum, Jong Bum Lee   +5 more
wiley   +1 more source