Copper homeostasis and neurodegenerative diseases [PDF]
Neural Regeneration ResearchCopper, one of the most prolific transition metals in the body, is required for normal brain physiological activity and allows various functions to work normally through its range of concentrations. Copper homeostasis is meticulously maintained through a
Yuanyuan Wang +4 more
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Mechanisms and therapeutic strategies of copper homeostasis in the pathogenesis of sepsis-induced cardiomyopathy [PDF]
Frontiers in Cell and Developmental BiologySepsis-induced cardiomyopathy (SCM) is a severe, mortality-increasing sepsis complication, with copper homeostasis imbalance as a key pathogenic factor.
Zihao Xie +8 more
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Syntaxin 5 is required for copper homeostasis in Drosophila and mammals. [PDF]
PLoS ONE, 2010 Copper is essential for aerobic life, but many aspects of its cellular uptake and distribution remain to be fully elucidated. A genome-wide screen for copper homeostasis genes in Drosophila melanogaster identified the SNARE gene Syntaxin 5 (Syx5) as ...
Melanie Norgate +9 more
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Copper Homeostasis and Cuproptosis in Neurological Disorders [PDF]
Drug Design, Development and TherapyWu Liu,1,* Yan Xue,2,* Chenyin Cao,3,* Liting Yang,2 Lijun Zhang1,* 1School of Basic Medical Sciences, Xianning Medical College, Hubei University of Science and Technology, Xianning, Hubei, 437000, China; 2School of ...
Liu W, Xue Y, Cao C, Yang L, Zhang L
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Multifaceted Role of Copper Homeostasis in Gut Health: From Molecular Mechanisms to Therapeutic Interventions [PDF]
CellsIntestinal copper homeostasis governs gut health through its dual roles as an enzymatic cofactor and signaling mediator. This review discusses the molecular basis of copper absorption/transport, genetic regulation, and its functional impacts.
Fucheng Lu +7 more
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Copper homeostasis and cuproptosis in tumor biology: mechanistic insights and clinical perspectives [PDF]
Frontiers in ImmunologyCopper is considered a necessary trace element that plays crucial roles in energy production in mitochondria, redox regulation, and metabolism.
Zian Wang +8 more
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A critical role of copper homeostasis in the virulence of Klebsiella pneumoniae [PDF]
Communications BiologyPathogens are exposed to toxic levels of copper during infection, and copper tolerance may represent a general virulence mechanism utilized by bacteria to evade host defenses. Therefore, the precise regulation of copper homeostasis in bacteria is crucial
Mingxiao Han +10 more
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Copper homeostasis and cuproptosis: molecular mechanisms and therapeutic opportunities [PDF]
Molecular BiomedicineCopper, as an essential trace element, plays a critical role in various physiological processes including cell metabolism, nerve development, and immune function.
Hepu Chen +6 more
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Copper homeostasis and cuproptosis in health and disease
MedCommCopper is a vital trace element in human physiology, essential for the synthesis of numerous crucial metabolic enzymes and facilitation of various biological processes.
Yanqi Dang, Lisheng Wang, Guang Ji
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Copper homeostasis in macrophages: regulatory mechanisms and immunological implications [PDF]
Frontiers in ChemistryCopper is an essential micronutrient whose redox activity underpins a dual role in immunity: it serves as both an antimicrobial effector and a regulator of inflammatory signaling.
Wanting Yang +6 more
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