Copper chaperone Atox1 plays role in breast cancer cell migration [PDF]
, 2017 Copper (Cu) is an essential transition metal ion required as cofactor in many key enzymes. After cell uptake of Cu, the metal is transported by the cytoplasmic Cu chaperone Atox1 to P1B-type ATPases in the Golgi network for incorporation into Cu ...
Blockhuys, Stephanie +1 more
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Washington University Record, October 5, 2006 [PDF]
, 2006 https://digitalcommons.wustl.edu/record/2084/thumbnail ...
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The regulation of copper stress response genes in the Polychaete Nereis diversicolor during prolonged extreme copper contamination [PDF]
, 2014 Polychaetes are frequented in toxicological studies, one reason being that some members occupy shallow burrows in sediments and are maximally exposed to the contaminants that accumulate within them.
Galloway, Tamara S. +3 more
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Copper accumulation in senescent cells: Interplay between copper transporters and impaired autophagy
Redox Biology, 2018 Cellular senescence is characterized by irreversible growth arrest incurred through either replicative exhaustion or by pro-oncogenic cellular stressors (radioactivity, oxidative stress, oncogenic activation). The enrichment of senescent cells in tissues
Shashank Masaldan +8 more
doaj +1 more source
Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass. [PDF]
, 2017 X-chromosome inactivation is established during early development. In mice, transcriptional repression of the paternal X-chromosome (Xp) and enrichment in epigenetic marks such as H3K27me3 is achieved by the early blastocyst stage.
Anastassiadis, Konstantinos +14 more
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BMC Cancer, 2008 Background Copper homeostasis proteins ATP7A and ATP7B are assumed to be involved in the intracellular transport of cisplatin. The aim of the present study was to assess the relevance of sub cellular localisation of these transporters for acquired ...
Reedijk Jan +4 more
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Copper stimulates trafficking of a distinct pool of the Menkes copper ATPase (ATP7A) to the plasma membrane and diverts it into a rapid recycling pool [PDF]
, 2004 Luke Pase +3 more
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Distorted copper homeostasis with decreased sensitivity to cisplatin upon chaperone Atox1 deletion in Drosophila [PDF]
, 2018 Copper is an integral part of a number of proteins and thus an essential trace metal. However, free copper ions can be highly toxic and every organism has to carefully control its bioavailability.
Georgiev, Oleg +3 more
core
Involvement of Sp1 in Transcriptional Regulation of Atp7a During Hypoxia
The FASEB Journal, 2012 Genes with GC‐rich promoters were preferentially induced in the rodent intestine during iron deficiency. Moreover, promoters of iron homeostasis related genes (e.g. Dmt1 , Dcytb ) contain evolutionarily conserved Sp1 binding sites (GC‐rich sequences ...
Liwei Xie, James Collins
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