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Platination of the copper transporter ATP7A involved in anticancer drug resistance
Dalton Transactions, 2014The clinical efficacy of the widely used anticancer drug cisplatin is severely limited by the emergence of resistance. This is related to the drug binding to proteins such as the copper influx transporter Ctr1, the copper chaperone Atox1, and the copper pumps ATP7A and ATP7B. While the binding modes of cisplatin to the first two proteins are known, the
Calandrini V +6 more
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Expression in Mouse Kidney of Membrane Copper Transporters Atp7a and Atp7b
Nephron, 2002Copper is essential for activity of many enzymes, but is toxic in excess. Several copper proteins are required for copper homeostasis. <i>ATP7A</i> and <i>ATP7B</i> are genes encoding membrane copper transporters. <i>ATP7A</i>, defective in Menkes disease (MNK), is expressed in many tissues involved primarily in ...
Steven D P, Moore, Diane W, Cox
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Mutation Spectrum of ATP7A, the Gene Defective in Menkes Disease
1999Our knowledge about Menkes disease (MD) has expanded greatly since its description in 1962 as a new X-linked recessive neurodegenerative disorder of early infancy. Ten years later a defect in copper metabolism was established as the underlying biochemical deficiency.
Z, Tümer, L B, Møller, N, Horn
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Menkes disease and other ATP7A disorders
2015Juan M. Pascual, John H. Menkes
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An EcoRV polymorphism at the ovine Menkes disease locus (ATP7A)
Animal Genetics, 1994M D, Potts, V, Hanrahan, D F, Hill
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Gene symbol: ATP7A. Disease: Menkes disease.
Human genetics, 2004Z, Tumer +5 more
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Menkes Disease and Other Disorders Related to ATP7A
2019Cynthia Abou Zeid +2 more
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