Results 51 to 60 of about 5,775 (200)
Angewandte Chemie, EarlyView.Supramolecular mercaptosuccinic acid‐capped CdTe core‐type quantum dot‐encapsulated proteoliposome assemblies (MSA‐CdTe QD PLs) have been developed to study and unambiguously demonstrate real‐time transporter‐mediated turnover translocation of Pt(II)‐based complexes by transmembrane Cu(I) P‐type ATPase pumps (CopA).
Madujika A. Horadigala Gamage +7 more
wiley +2 more sources
Targeting copper metabolism to defeat KRAS-driven colorectal cancer
Molecular & Cellular Oncology, 2020 KRAS-driven cancers acquire profound metabolic dependencies that are intimately linked to tumor growth. Our work revealed that colorectal cancers that harbor KRAS mutations are addicted to copper metabolism. This adaptation renders tumor cells critically
Léo Aubert +2 more
doaj +1 more source
Menkes disease complicated by concurrent ACY1 deficiency: A case report
Frontiers in Genetics, 2023 Introduction: Menkes disease is an X‐linked recessive condition caused by mutations in the ATP7A gene, which leads to severe copper deficiency. Aminoacylase-1 deficiency is a rare inborn error of metabolism caused by homozygous or compound heterozygous ...
Alessia Mauri +14 more
doaj +1 more source
Cancer Treatment and Research Communications, 2022 Drug resistance of cancer cells is a significant impediment to effective chemotherapy. One primary reason for this is copper exporters - ATPase copper transporting alpha (ATP7A) and ATPase copper transporting beta (ATP7B). These molecular pumps belong to
Prajit Janardhanan +3 more
doaj +1 more source
ATP7A-mediated transport of Cu into the secretory pathway is essential for SSAO activity.
, 2018 (A) Cu limitation with 10 μM TTM for 48 h decreases the SSAO activity (n = 3). (B) SSAO activity in the epididymal adipose tissue from 13-wk-old male rats fed with Cu-adequate or low-Cu diet for 8 wk (n = 7).
Michael J. Wolfgang (701096) +9 more
core +1 more source
Cells, 2019 Membrane trafficking pathways emanating from the Golgi regulate a wide range of cellular processes. One of these is the maintenance of copper (Cu) homeostasis operated by the Golgi-localized Cu-transporting ATPases ATP7A and ATP7B.
Raffaella Petruzzelli +1 more
doaj +1 more source
Clinical and Translational Medicine, 2020 Background Breast cancer is the leading cause of death among women. Cisplatin is an effective drug for breast cancer, but resistance often develops during long term chemotherapy.
Ze Yu +4 more
doaj +1 more source
Mottled mice and non-mammalian models of Menkes disease
Frontiers in Molecular Neuroscience, 2015 Menkes disease is a multi-systemic copper metabolism disorder caused by mutations in the X-linked ATP7A gene and characterised by progressive neurodegeneration and severe connective tissue defects.
malgorzata elenartowicz +6 more
doaj +1 more source
Atp7a deficiency induces axonal and myelin developmental defects in zebrafish via ferroptosis
Neurobiology of DiseaseATP7A genetic mutations lead to Menkes disease (MD), a hereditary neurodegenerative disorder develops significant metabolic abnormalities including copper deficiency and hypomyelination, and even death before 3 years old.
You Wu +8 more
doaj +1 more source
Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease.
, 2016 Copper influences the pathogenesis of prion disease, but whether it is beneficial or detrimental remains controversial. Copper homeostasis is also essential for normal physiology, as highlighted by the spectrum of diseases caused by disruption of the ...
core +1 more source