Results 121 to 130 of about 56,901 (159)

Structural snapshot of the cholesterol-transport ATP-binding cassette proteins 1.

Biochemistry and cell biology = Biochimie et biologie cellulaire, 2019
The ATP-binding cassette (ABC) proteins play critical roles in maintaining lipid and sterol homeostasis in higher eukaryotes. In humans, several subfamily-A and -G members function as cholesterol transporters across the cellular membranes. Deficiencies of these ABC proteins can cause dyslipidemia that is associated with health conditions such as ...
Bala M, Xavier, William J, Jennings, Aiman A, Zein, Junmei, Wang, Jyh-Yeuan, Lee   +4 more
openaire   +2 more sources

ATP-Binding Cassette Transporter C4 is a Prostaglandin D2 Exporter in HMC-1 cells

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2020
ATP-binding cassette transporter C4 (ABCC4) is associated with multidrug resistance and the regulation of cell signalling. Some prostaglandins (PGs), including: PGE2, PGF2α, PGE3, and PGF3α are known substrates of ABCC4, and are released from some types of cells to exert their biological effects.
Nobuaki, Tanaka, Junya, Kawai, Noriyasu, Hirasawa, Nariyasu, Mano, Hiroaki, Yamaguchi   +4 more
openaire   +2 more sources

Caveolin-1 and ATP Binding Cassette Transporter A1 and G1-Mediated Cholesterol Efflux

Cardiovascular & Hematological Disorders-Drug Targets, 2014
Atherosclerosis is one major cause of cardiovascular diseases, the leading cause of death in industrialized countries. Reverse cholesterol transport (RCT) is thought to be one primary pathway to protect against atherosclerosis. The first and rate-limiting step of RCT is ATP-binding cassette transport A1 (ABCA1) and ABCG1-mediated cholesterol efflux ...
Faqi, Wang, Hong-mei, Gu, Da-wei, Zhang
openaire   +2 more sources

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

Nature Genetics, 1999
Tangier disease (TD) is an autosomal recessive disorder of lipid metabolism. It is characterized by absence of plasma high-density lipoprotein (HDL) and deposition of cholesteryl esters in the reticulo-endothelial system with splenomegaly and enlargement of tonsils and lymph nodes.
M, Bodzioch, E, Orsó, J, Klucken, T, Langmann, A, Böttcher, W, Diederich, W, Drobnik, S, Barlage, C, Büchler, M, Porsch-Ozcürümez, W E, Kaminski, H W, Hahmann, K, Oette, G, Rothe, C, Aslanidis, K J, Lackner, G, Schmitz   +16 more
openaire   +2 more sources

Expression of ATP-binding cassette membrane transporters in a HIV-1 transgenic rat model

Biochemical and Biophysical Research Communications, 2014
P-glycoprotein (P-gp, product of Mdr1a and Mdr1b genes), multidrug resistance associated proteins (Mrps), and breast cancer resistance protein (Bcrp), all members of the ATP-binding cassette (ABC) membrane-associated drug transporters superfamily, can significantly restrict the entry of antiretroviral drugs (ARVs) into organs which exhibit a barrier ...
Kevin R, Robillard, Md Tozammel, Hoque, Reina, Bendayan   +2 more
openaire   +2 more sources

Human Aldehyde Oxidase 1 Interacts with ATP-binding Cassette Transporter-1 and Modulates its Activity in Hepatocytes

Hormone and Metabolic Research, 2007
AOX1, a member of the cytosolic molybdenum hydroxylase family, has been identified by us earlier as an ABCA1-interacting protein. AOX1 is well-described as xenobiotic metabolizing enzyme, which upon oxidation of acetaldehyde and retinaldehyde to acetic acid and retinoic acid generates reactive oxygen species.
A. Sigruener, C. Buechler, E. Orsó, A. Hartmann, P. J. Wild, L. Terracciano, M. Roncalli, S. R. Bornstein, G. Schmitz   +8 more
openaire   +3 more sources

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

Nature Genetics, 1999
Tangier disease (TD) was first discovered nearly 40 years ago in two siblings living on Tangier Island. This autosomal co-dominant condition is characterized in the homozygous state by the absence of HDL-cholesterol (HDL-C) from plasma, hepatosplenomegaly, peripheral neuropathy and frequently premature coronary artery disease (CAD).
S, Rust, M, Rosier, H, Funke, J, Real, Z, Amoura, J C, Piette, J F, Deleuze, H B, Brewer, N, Duverger, P, Denèfle, G, Assmann   +10 more
openaire   +2 more sources

Caveolin-1 interacts with ATP binding cassette transporter G1 (ABCG1) and regulates ABCG1-mediated cholesterol efflux

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2014
ATP-binding cassette transporter G1 (ABCG1) plays an important role in macrophage reverse cholesterol transport in vivo by promoting cholesterol efflux onto lipidated apoA-I. However, the underlying mechanism is unclear. Here, we found that ABCG1 co-immunoprecipitated with caveolin-1 (CAV1) but not with flotillin-1 and -2.
Hong-Mei, Gu, Fa-Qi, Wang, Da-Wei, Zhang
openaire   +2 more sources

Oxidized LDL upregulated ATP binding cassette transporter-1 in THP-1 macrophages.

Acta pharmacologica Sinica, 2004
To study the effect of oxidized low density lipoprotein (ox-LDL) on ATP binding cassette transporter A1 (ABCA1) in THP-1 macrophages.After exposing the cultured THP-1 macrophages to ox-LDL for different periods, cholesterol efflux was determined by FJ-2107P type liquid scintillator.
Chao-ke, Tang, Guang-hui, Yi, Jun-hao, Yang, Lu-shan, Liu, Zuo, Wang, Chang-geng, Ruan, Yong-zong, Yang   +6 more
openaire   +1 more source

[Cloning and Ion Transportation of Cryptosporidium andersoni ATP-binding Cassette 1 Gene].

Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 2018
To investigate the transportation of intracellular and extracellular K(+), Ca(2+), Na(+) and Mg(2+) under the function of Cryptosporidium andersoni ATP-binding cassette (CaABC) 1 gene.CaABC1 gene was amplified by PCR using specifically designed primers.
Ju-hua, Wang, Pan, Wang, Chuan-huan, Liu, Xiu-mei, Sun, Qian-qian, Xie, Xiu-heng, Xue   +5 more
openaire   +1 more source