Results 91 to 100 of about 27,747 (231)

Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2

Journal of Lipid Research, 2005
The process of cholesterol absorption has yet to be completely defined at the molecular level. Because of its ability to esterify cholesterol for packaging into nascent chylomicrons, ACAT2 plays an important role in cholesterol absorption.
Ryan E. Temel, Richard G. Lee, Kathryn L. Kelley, Matthew A. Davis, Ramesh Shah, Janet K. Sawyer, Martha D. Wilson, Lawrence L. Rudel   +7 more
doaj   +1 more source

Depletion of Pre-β-high Density Lipoprotein by Human Chymase Impairs ATP-binding Cassette Transporter A1- but Not Scavenger Receptor Class B Type I-mediated Lipid Efflux to High Density Lipoprotein*

Journal of Biological Chemistry, 2004
The ATP-binding cassette transporter A1 (ABCA1) mediates the efflux of cellular unesterified cholesterol and phospholipid to lipid-poor apolipoprotein A-I.
E. Favari, Miriam Lee, L. Calabresi, G. Franceschini, F. Zimetti, F. Bernini, P. Kovanen   +6 more
semanticscholar   +1 more source

A primary cell‐based fluidic co‐culture model to investigate drug transport across the human placenta

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of a flow‐driven in vitro model of the human placental barrier designed to study transport processes during pregnancy. The model recreates key features of the maternal–fetal interface, enabling the investigation of how nutrients and therapeutic compounds cross the placental barrier under physiologically ...
Barbara Fuenzalida, Nadja Koechli, Edgar Ontsouka, Chennakesava Cuddapah, Martin Mueller, Bram Sengers, Frantisek Staud, Christiane Albrecht   +7 more
wiley   +1 more source

The Zinc Finger Protein 202 (ZNF202) Is a Transcriptional Repressor of ATP Binding Cassette Transporter A1 (ABCA1) and ABCG1 Gene Expression and a Modulator of Cellular Lipid Efflux*

Journal of Biological Chemistry, 2001
The zinc finger gene 202 (ZNF202) located within a hypoalphalipoproteinemia susceptibility locus on chromosome 11q23 is a transcriptional repressor of various genes involved in lipid metabolism.
M. Porsch-Özçürümez, T. Langmann, Susanne Heimerl, Hana Borsukova, W. Kaminski, W. Drobnik, C. Honer, C. Schumacher, G. Schmitz   +8 more
semanticscholar   +1 more source

Molecular Insights Into Canine Hepatocellular Carcinoma: A Cross‐Species Transcriptomic Comparison With Human HCC

Molecular Carcinogenesis, Volume 65, Issue 4, Page 523-536, April 2026.
ABSTRACT Canine hepatocellular carcinoma (HCC) requires further molecular characterization to identify diagnostic and therapeutic targets, and to establish whether dogs with this condition can model the human disease. Accordingly, we aimed to identify differentially expressed genes (DEGs) in canine HCC and evaluate cross‐species transcriptomic ...
Mohammad Arif, MD Nazmul Hasan, Nobuhiro Nozaki, Yutaro Ide, Yoshiyuki Akiyama, Shaohsu Wang, Most Shumi Akhter Shathi, Osamu Yamato, Naoki Miura   +8 more
wiley   +1 more source

Tetraopes Milkweed Beetle Genomes Elucidate the Adaptive Basis of a Temperate Coevolutionary Radiation

Molecular Ecology Resources, Volume 26, Issue 3, April 2026.
ABSTRACT The coevolutionary radiation of 27 species of Tetraopes longhorned beetles and their Asclepias milkweed hosts represents a classic example of adaptive evolution driven by plant chemical defences and herbivore counteradaptations. Investigations to date, however, have focused on a single species, Tetraopes tetrophthalmus, which feeds on the ...
Sangil Kim, Brian D. Farrell
wiley   +1 more source

A high cholesterol diet accelerates Alzheimer's progression by promoting fibrotic damage in rats

Brain Disorders
The literature documents the ability of oxysterols and TGFβ to cause fibrotic damage in the brain. Our study explores the potential mechanisms of oxysterol interactions with fibrotic mediators in Alzheimer's disease.
Ashmita Das, Durlav Chowdhury, Dilip Sharma, Rahul Manna, Surendra H. Bodakhe   +4 more
doaj   +1 more source

PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine

Journal of Lipid Research, 2007
Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyzes oxidative cleavage of the sterol side chain in the bile acid biosynthetic pathway in the liver and 27-hydroxylation of cholesterol in most tissues. Recent studies suggest that 27-hydroxycholesterol (
Tiangang Li, Wenling Chen, John Y.L. Chiang   +2 more
doaj   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, Volume 600, Issue 5, Page 591-611, March 2026.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source