Results 111 to 120 of about 12,429 (225)

Stimulation of the Liver X Receptor Pathway Inhibits HIV-1 Replication via Induction of ATP-Binding Cassette Transporter A1

, 2010
Cholesterol plays an important role in the HIV life cycle, and infectivity of cholesterol-depleted HIV virions is significantly impaired. Recently, we demonstrated that HIV-1, via its pro-tein Nef, inhibits the activity of the major cellular cholesterol ...
Lucas Jennelle, Alan T. Remaley, Nigora Mukhamedova, Zahedi Mujawar, Tatiana Pushkarsky, Fatah Kashanchi, Larisa Dubrovsky, Michael Bukrinsky, Angela Grant, Yana Kiselyeva, Dmitri Sviridov, Matthew P. Morrow   +11 more
core  

ATP-Binding Cassette Transporter A1 (ABCA 1) Expression in Adipose Tissue and Its Modulation with Insulin Resistance in Obesity [Corrigendum]

Diabetes, Metabolic Syndrome and Obesity, 2019
Vincent V, Thakkar H, Aggarwal S, et al. Diabetes Metab Syndr Obes. 2019:12;275–284.On page 283, the Acknowledgements section should be presented as follows: The authors would like to acknowledge Dr Manjunath Maruti Pol, Dr ...
Vincent V, Thakkar H, Aggarwal S, Mridha AR, Ramakrishnan L, Singh A   +5 more
doaj  

Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a protein kinase C δ pathway

Journal of Lipid Research, 2007
Abnormal HDL metabolism among patients with diabetes and insulin resistance may contribute to their increased risk of atherosclerosis. ABCA1 mediates the transport of cholesterol and phospholipids from cells to HDL apolipoproteins and thus modulates HDL ...
Wang Yutong, John F. Oram
doaj   +1 more source

Beyond the Known and Established Neurodegenerative Effects: Roles of APOE Across a Wide Spectrum of Pathophysiological Condition

MedComm, Volume 7, Issue 6, June 2026.
APOE is widely recognized for its role in neurodegeneration and cardiovascular disease, but its different genotypes also influence body composition, affecting obesity, bone density, and muscle mass, through their central role in lipid transport and metabolism.
Miriam Frosina, Samantha Maurotti, Alberto Castagna, Tiziana Montalcini, Arturo Pujia, Luca Tirinato   +5 more
wiley   +1 more source

Impaired ATP-binding cassette transporter A1-mediated sterol efflux from oxidized LDL-loaded macrophages

, 2005
We investigated the interaction of oxidized low density lipoprotein (OxLDL) with the ATP-binding cassette A1 (ABCA1) pathway in J774 macrophages.
Adorni, Maria Pia, E. Favari, AE Bortnick, Favari, Elda, Francesca Zimetti, Zanotti, Ilaria, Zimetti, Francesca, Maria Pia Adorni, Elda Favari, M. Canavesi, Monica Canavesi, Bernini, Franco, M. Adorni, Franco Bernini, A. Bortnick, Anna E. Bortnick, Ilaria Zanotti, BORTNICK A. E., F. Bernini, F. Zimetti, Bortnick, Anna E., I. Zanotti, Canavesi, Monica, CANAVESI M.   +23 more
core   +1 more source

Quercetin enhances ABCA1 expression and cholesterol efflux through a p38-dependent pathway in macrophages

Journal of Lipid Research, 2012
ATP-binding cassette transporter A1 (ABCA1) plays a crucial role in exporting cholesterol from macrophages, a function relevant to its involvement in the prevention of atherosclerosis.
Yu-Cheng Chang, Tzong-Shyuan Lee, An-Na Chiang   +2 more
doaj   +1 more source

Impact of Methyl-β-Cyclodextrin and Apolipoprotein A-I on The Expression of ATP-Binding Cassette Transporter A1 and Cholesterol Depletion in C57BL/6 Mice Astrocytes. [PDF]

Cell J, 2021
Azizidoost SH, Babaahmadi-Rezaei H, Nazeri Z, Cheraghzadeh M, Kheirollah A.   +4 more
europepmc   +1 more source

Pathways of Protein Secretion in Prokaryotes and Eukaryotes: Molecular Mechanisms, Biological Functions, and Therapeutic Opportunities

MedComm, Volume 7, Issue 6, June 2026.
This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang, Jingfei Shi, Linlin Xu, Guangrui Zhao, Yue Chen, Lin Cheng, Xiaokang Li, Zhigang Sun, Shuhong Huang   +8 more
wiley   +1 more source

Adipose Tissue ATP Binding Cassette Transporter A1 Contributes to High-Density Lipoprotein Biogenesis In Vivo

, 2011
Background— Adipose tissue (AT) is the body's largest free cholesterol reservoir and abundantly expresses ATP binding cassette transporter A1 (ABCA1), a key cholesterol transporter for high-density lipoprotein (HDL) biogenesis ...
Chung, Soonkyu, Soonkyu Chung, Janet K. Sawyer, Sawyer, Janet K., Parks, John S., John S. Parks, Abraham K. Gebre, Nobuyo Maeda, Gebre, Abraham K., Maeda, Nobuyo   +9 more
core   +1 more source

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source