Results 121 to 130 of about 12,429 (225)

Depletion of microglial compensation in glial network: Disease‐associated response dynamics in the revised amyloid hypothesis

Neuroprotection, Volume 4, Issue 2, Page 131-142, June 2026.
The critical transition from amyloid pathology to irreversible neuronal loss in Alzheimer's disease hinges on the microglial response. This review aims to systematize the patterns of how microglia react within the glial context. Abstract Microglia mount coordinated, stage‐dependent compensatory programs in response to early amyloid β (Aβ) accumulation ...
Songtao Lei, Zixuan Huang, Wen Wang, Yan Meng   +3 more
wiley   +1 more source

MicroRNA-758 Regulates Cholesterol Efflux Through Posttranscriptional Repression of ATP-Binding Cassette Transporter A1

, 2011
Objective— The ATP-binding cassette transporter A1 (ABCA1) is a major regulator of macrophage cholesterol efflux and protects cells from excess intracellular cholesterol accumulation; however, the mechanism involved in ...
Daniel Cirera-Salinas, Leigh Goedeke, Carlos Fernández-Hernando, Alessandro G. Salerno, Cristina M. Ramirez, Alberto Dávalos, Nikhil Warrier, Yajaira Suárez   +7 more
core   +1 more source

Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Portal Hypertension &Cirrhosis, Volume 5, Issue 2, Page 189-206, June 2026.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang, Zhenyu Liu, Jun Lin, Weijing Zhang, Xianzhi Liu, Tong Zhang   +5 more
wiley   +1 more source

Correlation of ATP Binding Cassette Transporter A1 Gene Polymorphisms and Lower Extremity Atherosclerotic Disease [PDF]

, 2017
目的：进行三磷酸腺苷结合盒转运体A1（ATP binding cassette transporter A1,ABCA1）基因单核苷酸多态性（single nucleotide polymorphisms,SNP）与下肢动脉粥样硬化（lower extremity atherosclerotic disease,LEAD）的关联分析。方法：收集福建省闽南地区630例体检者（314例LEAD者和316例正常者）的临床资料及外周血;采用Sequenom Mass ...
连霞, 戴成家, 林小凤, 费燕
core  

Advances in gene cloning and functional genomics approaches for wheat (Triticum aestivum L.) improvement

The Plant Genome, Volume 19, Issue 2, June 2026.
Abstract Wheat (Triticum aestivum L.) is a globally important cereal crop which provides ∼20% calories in human diet. Identifying genes and elucidating their functions is still challenging in wheat due to its large genome (∼16 Gb) with significant amount of repetitive elements.
Santosh Gudi, Khizar Razzaq, Jatinder Singh, Luis Del Rio Mendoza, Mohamed Khan, Rajeev Gupta, Upinder Gill   +6 more
wiley   +1 more source

Calpain‐4 Knockdown Modulates Cholesterol Metabolism and LXRα Nuclear Localization in Experimental Alcohol‐Related Liver Disease

Alcohol, Clinical and Experimental Research, Volume 50, Issue 6, June 2026.
Calpain‐4 knockdown in alcohol‐related liver disease promotes LXRα nuclear translocation and HMGCR cleavage, enhancing cholesterol efflux via upregulation of ABCA1/ABCG1 and CPT‐1. This mechanism reduces hepatic cholesterol accumulation and microvesicular steatosis without affecting triglycerides or inflammatory markers, identifying calpain‐4 as a ...
Noriko Kitano, Jiang Li, Sam Taborski, Charis‐Marie Vanderpuye, Pooja Muddasani, Sudrishti Chaudhary, Jia‐Jun Liu, Silvia Liu, Juliane I. Beier, Josepmaria Argemi, Ramon Bataller, Gavin E. Arteel   +11 more
wiley   +1 more source

ATP Binding Cassette Transporter A1 (ABCA1) Associated Proteins:Potential Drug Targets in the Metabolic Syndrome and Atherosclerotic Disease?

, 2012
The metabolic syndrome is defined as a cluster of disorders including visceral obesity, insulin resistance, hypertension, hypertriglyceridemia and low HDL.
Bauer, Sabrina, Buechler, Christa
core   +1 more source

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, Volume 183, Issue 12, Page 3173-3194, June 2026.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Leukocyte ATP-binding cassette transporter G1 gene expression is reduced in type 2 diabetes mellitus

, 2008
Leukocyte ATP-Binding Cassette Transporter G1 Gene Expression is Reduced in Type 2 Diabetes Mellitus Reverse cholesterol transport Reverse cholesterol transport is a pathway which transports cholesterol from extrahepatic cells and tissues to the liver ...
Wong, Y, Tan, KCB, Zhou, H, Shiu, SWM
core  

FvMAPK6‐Mediated FvMYB44s/FvSWEET1 Dual‐Layer Regulation Modulates Sugar Accumulation in Strawberry Fruit, With FvSPS3 Enabling Quality–Yield Balance

Plant Biotechnology Journal, Volume 24, Issue 6, Page 4221-4239, June 2026.
ABSTRACT Sugar content is a key determinant of fruit quality, and sugars also act as signalling molecules that regulate ripening processes, including anthocyanin accumulation. However, the molecular mechanisms underlying sugar accumulation and sugar signal‐mediated ripening remain incompletely understood.
Qianqian Feng, Lingzhi Wei, Ting Liu, Kexin Wang, Xiaojing Li, Chuang Liu, Ronghui Sun, Xia Li, Zhaonan Yin, Yanrong Wei, Huazhao Yuan, Qian Li, Bingbing Li   +12 more
wiley   +1 more source