Results 141 to 150 of about 1,999,074 (184)
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ATP-binding cassette transporter A1: regulation of cholesterol efflux
Biochemical Society Transactions, 2004The ATP-binding cassette transporter A1 (ABCA1) is involved in the regulation of cholesterol efflux from cells. Mutations in ABCA1 give rise to familial high-density lipoprotein (HDL) deficiency and Tangier disease, which is characterized by very low levels of HDL in plasma and cholesteryl ester accumulation in tonsils and other reticuloendothelial ...
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The Role of Different Regions of ATP-Binding Cassette Transporter A1 in Cholesterol Efflux
Biochemistry, 2007ABCA1 is a key element of cholesterol efflux, but the mechanism of ABCA1-dependent cholesterol efflux is still unclear. Monoclonal antibodies against ABCA1 were used to map functional domains of ABCA1. Two antibodies were directed against a fragment of the first extracellular loop of ABCA1, and the third antibody was directed against a fragment of the ...
Nigora, Mukhamedova +4 more
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The role of the ATP-binding cassette transporter A1 (ABCA1) in cholesterol metabolism
2021The release of cellular cholesterol and phospholipid to apolipoproteins is thought to be the initial step in high density lipoprotein (HDL) formation. HDL is the lipid carrier of reverse cholesterol transport (RCT), the process by which cholesterol is mobilized from the periphery.
Anna E. Bortnick, George H. Rothblat
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Regulation of ATP-Binding Cassette Transporter A1 Transcription by Thyroid Hormone Receptor
Biochemistry, 2004Transcriptional regulation of the ATP-binding cassette transporter (ABCA1) gene is complex. It involves multiple transcription start sites and the binding of several different transcription factors to the ABCA1 promoter region. Cholesterol- and oxysterol-mediated up-regulation of ABCA1 transcription includes the binding of the liver X receptor and ...
Jarkko, Huuskonen +4 more
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ATP-binding cassette transporter A1, fatty acids, and cholesterol absorption
Current Opinion in Lipidology, 2003A significant advance in our understanding of the reverse cholesterol transport pathway occurred in 1999 with the identification of defects in the ATP-binding cassette transporter A1 gene as the cause of Tangier disease. Since this discovery, an overwhelming number of experiments have been conducted to further define the function of this gene.
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Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages
Biochemical and Biophysical Research Communications, 2004The ATP-binding-cassette transporter A1 (ABCA1) plays an essential role in cellular cholesterol efflux and helps prevent macrophages from becoming foam cells. The statins are widely used as cholesterol-lowering agents and have other anti-atherogenic actions.
Hirohito, Sone +15 more
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ATP-binding cassette transporter A1
Current Opinion in Lipidology, 2014ATP-binding cassette transporter A1 (ABCA1) facilitates cellular cholesterol efflux to lipid-poor apolipoprotein AI (apoAI) and plays a key role in the formation and function of HDL. This review summarizes the advances and new insights in the role of ABCA1 in cardiovascular and metabolic diseases from studies in genetically engineered mice.Recent ...
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ATP Binding Cassette A1 Transporter Function and Tangier Disease
2010The ATP binding cassette A1 (ABCA1) transporter facilitates the efflux of free cholesterol and phospholipid onto high density lipoprotein (HDL) particles, mainly very small discoidal precursor HDL particles, known as prebeta 1 HDL. Once these particles pick up these lipids, they are converted to small discoidal alpha 4 migrating HDL and with ...
Ernst J. Schaefer, H. Bryan Brewer
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Posttranscriptional Regulation of ATP-Binding Cassette Transporter A1 in Lipid Metabolism
DNA and Cell Biology, 2013Several lines of evidence have shown that posttranscriptional regulations play an important role in the modulation of ATP-binding cassette transporter A1 (ABCA1) expression and function.The clearance of ABCA1 mRNA as well as the trafficking, stability, degradation, and activity of the ABCA1 protein are regulated by diverse posttranscriptional ...
Yun-cheng, Lv +5 more
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ATP binding cassette transporter A1 - key roles in cellular lipid transport and atherosclerosis
Molecular and Cellular Biochemistry, 2002ATP-binding cassette transporter A1 (ABCA1) was recently recognized as the mutant molecule responsible for Tangier disease with low HDL levels, accumulation of cholesteryl esters in tissues, and increased risk of cardiovascular disease. Extensive studies for the past 2 years have recognized the critical role of ABCA1 in cholesterol and phospholipid ...
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