Results 141 to 150 of about 11,658 (183)

Regulation of ATP-Binding Cassette Transporter A1 Transcription by Thyroid Hormone Receptor

Biochemistry, 2004
Transcriptional regulation of the ATP-binding cassette transporter (ABCA1) gene is complex. It involves multiple transcription start sites and the binding of several different transcription factors to the ABCA1 promoter region. Cholesterol- and oxysterol-mediated up-regulation of ABCA1 transcription includes the binding of the liver X receptor and ...
Jarkko, Huuskonen, Meeta, Vishnu, Clive R, Pullinger, Phoebe E, Fielding, Christopher J, Fielding   +4 more
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ATP-binding cassette transporter A1, fatty acids, and cholesterol absorption

Current Opinion in Lipidology, 2003
A significant advance in our understanding of the reverse cholesterol transport pathway occurred in 1999 with the identification of defects in the ATP-binding cassette transporter A1 gene as the cause of Tangier disease. Since this discovery, an overwhelming number of experiments have been conducted to further define the function of this gene.
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Statins downregulate ATP-binding-cassette transporter A1 gene expression in macrophages

Biochemical and Biophysical Research Communications, 2004
The ATP-binding-cassette transporter A1 (ABCA1) plays an essential role in cellular cholesterol efflux and helps prevent macrophages from becoming foam cells. The statins are widely used as cholesterol-lowering agents and have other anti-atherogenic actions.
Hirohito, Sone, Hitoshi, Shimano, Miao, Shu, Masanori, Nakakuki, Akimitsu, Takahashi, Masakazu, Sakai, Yuichiro, Sakamoto, Tomotaka, Yokoo, Ken, Matsuzaka, Hiroaki, Okazaki, Yoshimi, Nakagawa, Kaoruko Tada, Iida, Hiroaki, Suzuki, Hideo, Toyoshima, Seikoh, Horiuchi, Nobuhiro, Yamada   +15 more
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ATP-binding cassette transporter A1

Current Opinion in Lipidology, 2014
ATP-binding cassette transporter A1 (ABCA1) facilitates cellular cholesterol efflux to lipid-poor apolipoprotein AI (apoAI) and plays a key role in the formation and function of HDL. This review summarizes the advances and new insights in the role of ABCA1 in cardiovascular and metabolic diseases from studies in genetically engineered mice.Recent ...
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ATP-Binding cassette transporter A1 is involved in hepatic α-tocopherol secretion

The Journal of Nutritional Biochemistry, 2010
Vitamin E (alpha-tocopherol) is an essential fat-soluble nutrient with antioxidant properties. alpha-Tocopherol transfer protein (alpha-TTP), the product of the gene responsible for familial isolated vitamin E deficiency, plays an important role in maintaining the plasma alpha-tocopherol level by mediating the secretion of alpha-tocopherol by the liver.
Mototada, Shichiri, Yasukazu, Takanezawa, Daisy E, Rotzoll, Yasukazu, Yoshida, Tomokuni, Kokubu, Kazumitsu, Ueda, Hiroshi, Tamai, Hiroyuki, Arai   +7 more
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ATP Binding Cassette A1 Transporter Function and Tangier Disease

2010
The ATP binding cassette A1 (ABCA1) transporter facilitates the efflux of free cholesterol and phospholipid onto high density lipoprotein (HDL) particles, mainly very small discoidal precursor HDL particles, known as prebeta 1 HDL. Once these particles pick up these lipids, they are converted to small discoidal alpha 4 migrating HDL and with ...
Ernst J. Schaefer, H. Bryan Brewer
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Posttranscriptional Regulation of ATP-Binding Cassette Transporter A1 in Lipid Metabolism

DNA and Cell Biology, 2013
Several lines of evidence have shown that posttranscriptional regulations play an important role in the modulation of ATP-binding cassette transporter A1 (ABCA1) expression and function.The clearance of ABCA1 mRNA as well as the trafficking, stability, degradation, and activity of the ABCA1 protein are regulated by diverse posttranscriptional ...
Yun-cheng, Lv, Kai, Yin, Yu-chang, Fu, Da-wei, Zhang, Wu-jun, Chen, Chao-ke, Tang   +5 more
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ATP binding cassette transporter A1 - key roles in cellular lipid transport and atherosclerosis

Molecular and Cellular Biochemistry, 2002
ATP-binding cassette transporter A1 (ABCA1) was recently recognized as the mutant molecule responsible for Tangier disease with low HDL levels, accumulation of cholesteryl esters in tissues, and increased risk of cardiovascular disease. Extensive studies for the past 2 years have recognized the critical role of ABCA1 in cholesterol and phospholipid ...
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Scavenger receptor BI and ATP-binding cassette transporter A1 in reverse cholesterol transport and atherosclerosis

Current Opinion in Lipidology, 2005
The appearance of scavenger receptor class B type I (SR-BI) and ATP-binding cassette transporter A1 (ABCA1) in macrophages and liver implicates these transporters in different stages of reverse cholesterol transport. This review focuses on the role of SR-BI and ABCA1 in reverse cholesterol transport in the context of atherosclerotic lesion development ...
Miranda, Van Eck, Marieke, Pennings, Menno, Hoekstra, Ruud, Out, Theo Jc, Van Berkel   +4 more
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The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a β2-syntrophin/utrophin complex

Biochemical and Biophysical Research Communications, 2002
Recent work identified ABCA1 as the major regulator of plasma HDL-cholesterol responsible for the removal of excess choline-phospholipids and cholesterol from peripheral cells and tissues. ABCA1 function may depend on the association with heteromeric proteins and to identify these candidates a human liver yeast two-hybrid library was screened with the ...
Christa, Buechler, Alfred, Boettcher, Salim Maa, Bared, Mario C O, Probst, Gerd, Schmitz   +4 more
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