Results 131 to 140 of about 1,999,074 (184)

The yeast plasma membrane ATP binding cassette (ABC) transporter aus1

, 2011
The ATP binding cassette (ABC) transporter Aus1 is expressed under anaerobic growth conditions at the plasma membrane of the yeast Saccharomyces cerevisiae and is required for sterol uptake. These observations suggest that Aus1 promotes the translocation
Herrmann, A., Dittmar, G., Marek, M., Gunnar Dittmar, Marek, Magdalena, Günther-Pomorski, Thomas, Gabriele Schreiber, Schreiber, Gabriele, Magdalena Marek, Daleke, D.L., Sigrid Milles, Schreiber, G., Thomas Günther Pomorski, Milles, S., Mueller, P., Müller, Peter, Herrmann, Andreas, Milles, Sigrid, Andreas Herrmann, Daleke, David L., Peter Müller, David L. Daleke, Pomorski, T.G., Dittmar, Gunnar   +23 more
core   +1 more source

Stimulation of the Liver X Receptor Pathway Inhibits HIV-1 Replication via Induction of ATP-Binding Cassette Transporter A1

, 2010
Cholesterol plays an important role in the HIV life cycle, and infectivity of cholesterol-depleted HIV virions is significantly impaired. Recently, we demonstrated that HIV-1, via its pro-tein Nef, inhibits the activity of the major cellular cholesterol ...
Lucas Jennelle, Alan T. Remaley, Nigora Mukhamedova, Zahedi Mujawar, Tatiana Pushkarsky, Fatah Kashanchi, Larisa Dubrovsky, Michael Bukrinsky, Angela Grant, Yana Kiselyeva, Dmitri Sviridov, Matthew P. Morrow   +11 more
core  

Onion peel extract increases hepatic low-density lipoprotein receptor and ATP-binding cassette transporter A1 messenger RNA expressions in Sprague-Dawley rats fed a high-fat diet

, 2012
In the present study, we hypothesized that onion peel extract (OPE) alters hepatic gene expression to improve blood cholesterol profiles. To investigate the effect of OPE to test our hypothesis, Sprague-Dawley rats were fed ad libitum for 8 weeks with ...
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core  

Glycaemic influences on the ATP-binding cassette transporter A1 (ABCA1)

, 2010
Increased glucose levels are associated with increased risk of vascular disease. The risk is elevated 2-4 fold in type 2 diabetes and there is a positive relationship between glucose (or HbA1c) levels and vascular disease in the general population.
Valabhji, Jonathan, Patel, Dipesh C, Johnston, Des   +2 more
core  

Knowing Your ABCs

JACC: Basic to Translational Science
George A. Karpouzas, MD, Nicoletta Ronda, MD, PhD   +1 more
doaj   +1 more source

Palmitoylation of ATP-Binding Cassette Transporter A1 Is Essential for Its Trafficking and Function [PDF]

Circulation Research, 2009
ATP-binding cassette transporter (ABC)A1 lipidates apolipoprotein A-I both directly at the plasma membrane and also uses lipids from the late endosomal or lysosomal compartment in the internal lipidation of apolipoprotein A-I. However, how ABCA1 targeting to these specific membranes is regulated remains unknown.
Michael R. Hayden, Roshni Singaraja, Jonathan Coutinho   +2 more
exaly   +3 more sources

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Effects of Pravastatin on the Expression of ATP-Binding Cassette Transporter A1

The Journal of Pharmacology and Experimental Therapeutics, 2004
In vitro inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase causes the suppression of liver X receptor (LXR) activity. Because LXR regulates the expression of ATP-binding cassette transporter (ABC) A1, which is involved in the high-density lipoprotein-related reverse cholesterol transport pathway, we examined the effects of an HMG ...
Hitoshi, Ando, Shuichi, Tsuruoka, Hisashi, Yamamoto, Toshinari, Takamura, Shuichi, Kaneko, Akio, Fujimura   +5 more
openaire   +2 more sources

Dynamic regulation of alternative ATP-binding cassette transporter A1 transcripts

Biochemical and Biophysical Research Communications, 2003
The ATP-binding cassette transporter A1 (ABCA1) gene, a major regulator of high-density lipoprotein (HDL) metabolism, utilizes several transcriptional start sites. The pattern of transcripts among tissues and cells differed significantly. The longest (class 1) transcripts were abundant in adult brain and fetal tissues.
Jarkko, Huuskonen, Monika, Abedin, Meeta, Vishnu, Clive R, Pullinger, Sergio E, Baranzini, John P, Kane, Phoebe E, Fielding, Christopher J, Fielding   +7 more
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ATP-binding cassette transporter A1 and cholesterol trafficking

Current Opinion in Lipidology, 2002
Two hallmarks of cardiovascular disease are the presence of sterol-laden macrophages in the artery wall and reduced plasma HDL levels. A cell membrane protein named ATP-binding cassette transporter A1 (ABCA1) mediates secretion of excess cholesterol from cells into the HDL metabolic pathway.
openaire   +2 more sources

The expression of ATP-binding cassette transporter A1 in Chinese overweight and obese patients

International Journal of Obesity, 2009
ATP-binding cassette transporters (ABCA1, ABCG1) and scavenger receptor class B type I (SR-BI) are the three most important cellular cholesterol transporters/receptor in regulating cholesterol efflux. We have investigated whether the expression of these transporters/receptor is altered in overweight and obese patients, and the potential association ...
M, Xu, H, Zhou, J, Wang, C, Li, Y, Yu
openaire   +2 more sources