Results 91 to 100 of about 12,429 (225)

PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine

Journal of Lipid Research, 2007
Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyzes oxidative cleavage of the sterol side chain in the bile acid biosynthetic pathway in the liver and 27-hydroxylation of cholesterol in most tissues. Recent studies suggest that 27-hydroxycholesterol (
Tiangang Li, Wenling Chen, John Y.L. Chiang   +2 more
doaj   +1 more source

HDL‐mimetic peptide treatment reverses APOE4‐induced transcriptomic and lipidomic alterations in the brain of humanized APOE mice

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD). ApoE4 has reduced lipidation capacity and impaired lipid transport, disrupting neuronal maintenance. The high‐density lipoprotein (HDL)‐mimetic peptide 4F offers a potential therapeutic strategy.
Allison Chang, Minwoo Kim, Matthew Glittenberg, Wenhui Qu, Danni Li, Ling Li   +5 more
wiley   +1 more source

A high cholesterol diet accelerates Alzheimer's progression by promoting fibrotic damage in rats

Brain Disorders
The literature documents the ability of oxysterols and TGFβ to cause fibrotic damage in the brain. Our study explores the potential mechanisms of oxysterol interactions with fibrotic mediators in Alzheimer's disease.
Ashmita Das, Durlav Chowdhury, Dilip Sharma, Rahul Manna, Surendra H. Bodakhe   +4 more
doaj   +1 more source

Silymarin and Its Isolated Flavanonol Lignans Are Liver X Receptor Antagonists

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Despite its long tradition in the treatment of liver‐related ailments, the precise mode of action of the milk thistle fruit extract remains vague. Here we identified liver X receptor as a molecular target of silymarin, a mixture of bioactive compounds from milk thistle extract, and its major flavanonol lignan components, which account for their anti ...
Nils C. Bandomir, Astrid Kaiser, Felix F. Lillich, Pascal Heitel   +3 more
wiley   +1 more source

Regulation of ATP-binding cassette transporter A1 In intimal-type arterial smooth muscle cells

, 2013
The removal of cholesterol from cells and formation of high-density lipoprotein (HDL) particles is critically dependent on the membrane lipid transporter ATP-binding cassette transporter A1 (ABCA1).
Pannu, Parveer Singh
core  

CYP46A1‐Targeted Treatment Alleviates Long‐Term White Matter Injury Following Traumatic Brain Injury by Promoting Cholesterol Metabolic Clearance and Remyelination

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Our findings demonstrate that CYP46A1 plays a critical role in regulating cholesterol homeostasis in microglia and that the targeting of CYP46A1 may offer a viable therapeutic approach for traumatic brain injury (TBI). The CYP46A1 activator Efavirenz reduces white matter damage by increasing the levels of the cholesterol metabolite 24OHC, thereby ...
Lin Li, You Shi, Qing Luo, Peiwen Guo, Taotao Jin, Xufang Ru, Zhouyang Jiang, Yin Niu, Wenyan Li, Yujie Chen, Zhi Chen   +10 more
wiley   +1 more source

Double deletions and missense mutations in the first nucleotide-binding fold of the ATP-binding cassette transporter A1 (ABCA1) gene in Japanese patients with Tangier disease

, 2002
Tangier disease (TD) is a rare autosomal recessive disease characterized by plasma high-density lipoprotein deficiency caused by an ATP-binding cassette transporter A1 (ABCA1) gene mutation. We describe three different mutations in Japanese patients with
Mabuchi, H., Yoshida, K., Yu, W., Inazu, A., Suzumura, T., Schmitz, G., Hayakawa, T., Suehiro, T., Higashikata, T., Guo, Z., Sano, R., Okamoto, M., Nohara, A., Wakasugi, K.   +13 more
core   +1 more source

Different cellular traffic of LDL-cholesterol and acetylated LDL-cholesterol leads to distinct reverse cholesterol transport pathwayss⃞

Journal of Lipid Research, 2007
Endocytosis of LDL and modified LDL represents regulated and unregulated cholesterol delivery to macrophages. To elucidate the mechanisms of cellular cholesterol transport and egress under both conditions, various primary macrophages were labeled and ...
Ming-Dong Wang, Robert S. Kiss, Vivian Franklin, Heidi M. McBride, Stewart C. Whitman, Yves L. Marcel   +5 more
doaj   +1 more source

Effect of Arabica Coffee Husk on Plasma Lipids and Obesity on Albino Rats

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Feeding on a high‐fat diet supplemented with Arabica coffee husks (CH) for 8 weeks led to an improvement in plasma lipids and adipose tissues in rats compared to the high‐fat diet. ABSTRACT Hyperlipidemia is a major risk factor for the development of cardiovascular diseases.
Shaheed Mohammed Alshaikhsaleh
wiley   +1 more source

Specific loss of ABCA1 (ATP-Binding Cassette Transporter A1) suppresses TCR (T-Cell Receptor) signaling and provides protection against atherosclerosis

, 2022
BACKGROUND\nMETHODS\nRESULTS\nCONCLUSIONS\nABCA1 (ATP-binding cassette transporter A1) mediates cholesterol efflux to apo AI to maintain cellular cholesterol homeostasis.
Yang, Y., Liu, L., Zhang, L., Ding, F., Wang, H., Eck, M. van, Wang, J., Zhao, Y., Du, S., Zhou, X.   +9 more
core   +1 more source