Results 241 to 250 of about 40,880 (280)

ATP Binding Cassette A1 Transporter Function and Tangier Disease

2010
The ATP binding cassette A1 (ABCA1) transporter facilitates the efflux of free cholesterol and phospholipid onto high density lipoprotein (HDL) particles, mainly very small discoidal precursor HDL particles, known as prebeta 1 HDL. Once these particles pick up these lipids, they are converted to small discoidal alpha 4 migrating HDL and with ...
Ernst J. Schaefer, H. Bryan Brewer
openaire   +1 more source

Palmitoylation of ATP-Binding Cassette Transporter A1 Is Essential for Its Trafficking and Function [PDF]

Circulation Research, 2009
ATP-binding cassette transporter (ABC)A1 lipidates apolipoprotein A-I both directly at the plasma membrane and also uses lipids from the late endosomal or lysosomal compartment in the internal lipidation of apolipoprotein A-I. However, how ABCA1 targeting to these specific membranes is regulated remains unknown.
R. Singaraja, Martin H. Kang, Kuljeet S. Vaid, Shaun S. Sanders, Gonzalo L. Vilas, Pamela Arstikaitis, Jonathan M Coutinho, R. Drisdel, Alaa El Din El-Husseini, W. N. Green, L. Berthiaume, M. Hayden   +11 more
semanticscholar   +3 more sources

Increased ATP-Binding Cassette Transporter A1 Expression in Alzheimer's Disease Hippocampal Neurons

Journal of Alzheimer's Disease, 2010
ATP-binding cassette transporter A1 (ABCA1) reduces amyloid-β burden in transgenic mouse models of Alzheimer's disease (AD). Associations between ABCA1 polymorphisms and AD risk are also established. Little is known regarding the regulation of ABCA1 expression in the brain and how this may be affected by AD.
Garner, Brett, McCann, H, Halliday, Glenda, Barnham, K J, Elliott, David, Kim, Woojin Scott, Agholme, Lotta, Kgedal, Katarina, Bhatia, Surabhi   +8 more
openaire   +3 more sources

Posttranscriptional Regulation ofATP-Binding Cassette Transporter A1in Lipid Metabolism

DNA and Cell Biology, 2013
Several lines of evidence have shown that posttranscriptional regulations play an important role in the modulation of ATP-binding cassette transporter A1 (ABCA1) expression and function.The clearance of ABCA1 mRNA as well as the trafficking, stability, degradation, and activity of the ABCA1 protein are regulated by diverse posttranscriptional ...
Yun-cheng, Lv, Kai, Yin, Yu-chang, Fu, Da-wei, Zhang, Wu-jun, Chen, Chao-ke, Tang   +5 more
openaire   +2 more sources

ATP-binding cassette transporter A1

Current Opinion in Lipidology, 2014
ATP-binding cassette transporter A1 (ABCA1) facilitates cellular cholesterol efflux to lipid-poor apolipoprotein AI (apoAI) and plays a key role in the formation and function of HDL. This review summarizes the advances and new insights in the role of ABCA1 in cardiovascular and metabolic diseases from studies in genetically engineered mice.Recent ...
openaire   +2 more sources

ATP binding cassette transporter A1 - key roles in cellular lipid transport and atherosclerosis

Molecular and Cellular Biochemistry, 2002
ATP-binding cassette transporter A1 (ABCA1) was recently recognized as the mutant molecule responsible for Tangier disease with low HDL levels, accumulation of cholesteryl esters in tissues, and increased risk of cardiovascular disease. Extensive studies for the past 2 years have recognized the critical role of ABCA1 in cholesterol and phospholipid ...
openaire   +2 more sources

Caveolin-1 and ATP Binding Cassette Transporter A1 and G1-Mediated Cholesterol Efflux

Cardiovascular & Hematological Disorders-Drug Targets, 2014
Atherosclerosis is one major cause of cardiovascular diseases, the leading cause of death in industrialized countries. Reverse cholesterol transport (RCT) is thought to be one primary pathway to protect against atherosclerosis. The first and rate-limiting step of RCT is ATP-binding cassette transport A1 (ABCA1) and ABCG1-mediated cholesterol efflux ...
Faqi, Wang, Hong-mei, Gu, Da-wei, Zhang
openaire   +2 more sources

Common gene polymorphism in ATP‐binding cassette transporter A1 and coronary artery disease: A genetic association study and a structural analysis

Journal of Cellular Biochemistry, 2020
ATP‐binding cassette transporter A1 (ABCA1) has a crucial role in removing intracellular cholesterol and plays a protective role against atherosclerosis.
M. Karimian, A. Momeni, Amir Farmohammadi, M. Behjati, Marjan Jafari, F. Raygan   +5 more
semanticscholar   +1 more source

The Role of Different Regions of ATP-Binding Cassette Transporter A1 in Cholesterol Efflux

Biochemistry, 2007
ABCA1 is a key element of cholesterol efflux, but the mechanism of ABCA1-dependent cholesterol efflux is still unclear. Monoclonal antibodies against ABCA1 were used to map functional domains of ABCA1. Two antibodies were directed against a fragment of the first extracellular loop of ABCA1, and the third antibody was directed against a fragment of the ...
Nigora, Mukhamedova, Ying, Fu, Michael, Bukrinsky, Alan T, Remaley, Dmitri, Sviridov   +4 more
openaire   +2 more sources

The expression of ATP-binding cassette transporter A1 in Chinese overweight and obese patients

International Journal of Obesity, 2009
ATP-binding cassette transporters (ABCA1, ABCG1) and scavenger receptor class B type I (SR-BI) are the three most important cellular cholesterol transporters/receptor in regulating cholesterol efflux. We have investigated whether the expression of these transporters/receptor is altered in overweight and obese patients, and the potential association ...
M, Xu, H, Zhou, J, Wang, C, Li, Y, Yu
openaire   +2 more sources