Results 71 to 80 of about 27,747 (231)

Cannabidiol and cannabigerol ameliorate steatotic liver disease via phosphocreatine buffering and lysosomal restoration

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) and cannabigerol (CBG) alleviate hepatic steatosis in obese mice by shifting energy buffering towards phosphocreatine and enhancing lysosomal lipid degradation and trafficking. These effects are associated with increased creatine kinase activity and lysobisphosphatidic acid (LBPA) levels, highlighting a previously unrecognised ...
Radka Kočvarová, Shahar Azar, Bella Agranovich, Ifat Abramovich, Saveliy Kirillov, Alina Nemirovski, Saja Baraghithy, Inbar Plaschkes, Emmanuelle Merquiol, Alexander Rouvinski, Galia Blum, Liad Hinden, Joseph Tam   +12 more
wiley   +1 more source

Nascent HDL formation by hepatocytes is reduced by the concerted action of serum amyloid A and endothelial lipase

Journal of Lipid Research, 2011
Inflammation is associated with significant decreases in plasma HDL-cholesterol (HDL-C) and apoA-I levels. Endothelial lipase (EL) is known to be an important determinant of HDL-C in mice and in humans and is upregulated during inflammation.
Joanne M. Wroblewski, Anisa Jahangiri, Ailing Ji, Frederick C. de Beer, Deneys R. van der Westhuyzen, Nancy R. Webb   +5 more
doaj   +1 more source

Stearoyl-CoA Desaturase Inhibits ATP-binding Cassette Transporter A1-mediated Cholesterol Efflux and Modulates Membrane Domain Structure*

Journal of Biological Chemistry, 2003
Liver X receptor/retinoid X receptor (LXR/RXR) transcription factors have been found to induce a number of genes involved in the regulation of cellular cholesterol efflux, including the ATP-binding cassette transporter A1 (ABCA1), which mediates the ...
Yu Sun, Mingming Hao, Yi Luo, Chien-ping Liang, D. Silver, C. Cheng, F. Maxfield, A. Tall   +7 more
semanticscholar   +1 more source

Hybrid sorghum breeding in China: A historical review and perspectives

Journal of Integrative Plant Biology, EarlyView.
To commemorate the 60th anniversary of the promotion and application of three‐line hybrid sorghum in China, this review highlights pivotal scientific breakthroughs, systematically summarizes the progress in hybrid sorghum breeding and dwarf sorghum breeding in the country, and presents an outlook on the future of sorghum breeding.
Xiangxiang Meng, Lu Li, Qian Qian, Liang Jiang, Zhaosheng Kong   +4 more
wiley   +1 more source

LXR-mediated activation of macrophage stearoyl-CoA desaturase generates unsaturated fatty acids that destabilize ABCA1

Journal of Lipid Research, 2004
Abnormal HDL metabolism among patients with diabetes and insulin resistance may contribute to their increased risk of atherosclerosis. ATP binding cassette transporter A1 (ABCA1) mediates the transport of cholesterol and phospholipids from cells to HDL ...
Yutong Wang, Buran Kurdi-Haidar, John F. Oram   +2 more
doaj   +1 more source

Glycaemic Influences on the ATP-Binding Cassette Transporter A1 (ABCA1)

, 2010
Increased glucose levels are associated with increased risk of vascular disease. The risk is elevated 2-4 fold in type 2 diabetes and there is a positive relationship between glucose (or HbA1c) levels and vascular disease in the general population. We tested the hypothesis that there is a glycaemia-mediated impairment of reverse cholesterol transport ...
Patel, Dipesh C., Patel, Dipesh C.
openaire   +3 more sources

The multidimensional regulation roles and mechanisms of calcium in fruit quality

Journal of Integrative Plant Biology, EarlyView.
This review explores how calcium signaling molecule integrates plant hormones, environmental cues, and developmental signals to influence external fruit traits, internal nutritional properties, and physiological disorders. ABSTRACT Calcium (Ca2+), a dual‐functional mineral that serves both as an essential structural factor and a signaling molecule ...
Fei Jiang, Siyang Gao, Mengdi Li, Zeqi Zhao, Chengwei Yang, Ji‐Hong Liu, Chunlong Li   +6 more
wiley   +1 more source

ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux

Journal of Lipid Research, 2004
Apolipoproteins, such as apolipoprotein A-I (apoA-I), can stimulate cholesterol efflux from cells expressing the ATP binding cassette transporter A1 (ABCA1).
M.L. Fitzgerald, A.L. Morris, A. Chroni, A.J. Mendez, V.I. Zannis, M.W. Freeman   +5 more
doaj   +1 more source

Phosphorylation and Stabilization of ATP Binding Cassette Transporter A1 by Synthetic Amphiphilic Helical Peptides [PDF]

Journal of Biological Chemistry, 2004
To investigate structural requirement of helical apolipoprotein to phosphorylate and stabilize ATP-binding cassette transporter A1 (ABCA1), synthetic peptides (Remaley, A. T., Thomas, F., Stonik, J. A., Demosky, S. J., Bark, S. E., Neufeld, E. B., Bocharov, A. V., Vishnyakova, T. G., Patterson, A. P., Eggerman, T.
Reijiro, Arakawa, Michi, Hayashi, Alan T, Remaley, Bryan H, Brewer, Yoshio, Yamauchi, Shinji, Yokoyama   +5 more
openaire   +2 more sources

SlGRF1 mediates gibberellin signaling to control cut‐budding in tomato

Journal of Integrative Plant Biology, EarlyView.
Upon wounding, cytokinin increases to initiate callus formation. Gibberellin enhances this, but later blocks bud formation by suppressing SlGRF1. Wounding‐induced protein SlGRF1 triggers buds via NAM1, EPF4, and ER2. Hormonal shifts control cut‐budding phases.
Yaping Xu, Yinhuan Xie, Huimin Jia, Qianqian Li, Xinqin Liu, Ting Ma, Zhaobo Lang, Qingfeng Niu   +7 more
wiley   +1 more source