Results 81 to 90 of about 27,747 (231)

Transmembrane Protein GbTMEM209 Inhibits Fibre Elongation via Competitive Interaction With GbHOX3 in Gossypium barbadense

Plant Biotechnology Journal, EarlyView.
ABSTRACT Sea Island cotton (Gossypium barbadense) produces premium‐quality fibres, yet the genetic basis underlying its fibre development remains elusive. Here, we identify two key non‐synonymous single nucleotide polymorphisms (SNPs, G/C and G/A) in the gene Gbar_D13G024080, which encodes the TRANSMEMBRANE PROTEIN 209 (TMEM209). These SNPs resulted in
Kaiyun Jiang, Nan Zhao, Jie Kong, Anhui Guo, Yuqi Liu, Meng Wang, Zixin Zhou, Mengling Sun, Weiran Wang, Jiahui Zhu, Daojun Yuan, Zhuanxia Pan, Pengbo Li, Suen Liu, Baosheng Guo, Huijing Li, Jingrou Zhang, Bin Li, Zhanghao Xia, Beibei Lv, Junyi Geng, Baoliang Wang, Alifu Aierxi, Xianlong Zhang, Lili Tu, Jinping Hua   +25 more
wiley   +1 more source

ABCA1-dependent lipid efflux to apolipoprotein A-I mediates HDL particle formation and decreases VLDL secretion from murine hepatocytes

Journal of Lipid Research, 2004
High levels of expression of the ATP binding cassette transporter A1 (ABCA1) in the liver and the need to over- or underexpress hepatic ABCA1 to impact plasma HDL levels in mice suggest a major role of the liver in HDL formation and in determining ...
Daisy Sahoo, Timothy C. Trischuk, Teddy Chan, Victor A.B. Drover, Samuel Ho, Giovanna Chimini, Luis B. Agellon, Ricky Agnihotri, Gordon A. Francis, Richard Lehner   +9 more
doaj   +1 more source

Apolipoprotein A-I Activates Protein Kinase Cα Signaling to Phosphorylate and Stabilize ATP Binding Cassette Transporter A1 for the High Density Lipoprotein Assembly*

Journal of Biological Chemistry, 2003
ATP-binding cassette transporter A1 (ABCA1) plays an essential role in the helical apolipoprotein-mediated assembly of high density lipoprotein, and the apolipoporteins stabilize ABCA1 against calpain-mediated degradation during the reaction ((2002) J ...
Y. Yamauchi, M. Hayashi, S. Abe‐Dohmae, S. Yokoyama   +3 more
semanticscholar   +1 more source

FvMAPK6‐Mediated FvMYB44s/FvSWEET1 Dual‐Layer Regulation Modulates Sugar Accumulation in Strawberry Fruit, With FvSPS3 Enabling Quality–Yield Balance

Plant Biotechnology Journal, EarlyView.
ABSTRACT Sugar content is a key determinant of fruit quality, and sugars also act as signalling molecules that regulate ripening processes, including anthocyanin accumulation. However, the molecular mechanisms underlying sugar accumulation and sugar signal‐mediated ripening remain incompletely understood.
Qianqian Feng, Lingzhi Wei, Ting Liu, Kexin Wang, Xiaojing Li, Chuang Liu, Ronghui Sun, Xia Li, Zhaonan Yin, Yanrong Wei, Huazhao Yuan, Qian Li, Bingbing Li   +12 more
wiley   +1 more source

Sterol-responsive Element-binding Protein (SREBP) 2 Down-regulates ATP-binding Cassette Transporter A1 in Vascular Endothelial Cells

Journal of Biological Chemistry, 2004
ATP-binding cassette transporter A1 (ABCA1) is a pivotal regulator of cholesterol efflux from cells to apolipoproteins, whereas sterol-responsive element-binding protein 2 (SREBP2) is the key protein regulating cholesterol synthesis and uptake.
L. Zeng, H. Liao, Yi Liu, Tzong-Shyuan Lee, Minjia Zhu, Xian Wang, M. Stemerman, Yi Zhu, J. Shyy   +8 more
semanticscholar   +1 more source

ABCA12 Frameshift Deletion in Domestic Cats With Ichthyosis Fetalis

Veterinary Dermatology, EarlyView.
ABSTRACT Background Ichthyosis fetalis (IF), also known as harlequin ichthyosis, is a rare and often fatal autosomal recessive congenital skin disorder. It is characterized by thickened, hard skin plaques and deep skin fissures that limit mobility and cause malformations of the eyes, lips and ears.
Jeanna M. Blake, Melissa P. Swan, Kari J. Ekenstedt   +2 more
wiley   +1 more source

Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high density lipoprotein

Journal of Lipid Research, 2015
The ability of HDL to support macrophage cholesterol efflux is an integral part of its atheroprotective action. Augmenting this ability, especially when HDL cholesterol efflux capacity from macrophages is poor, represents a promising therapeutic strategy.
Andrea J. Luthi, Nicholas N. Lyssenko, Duyen Quach, Kaylin M. McMahon, John S. Millar, Kasey C. Vickers, Daniel J. Rader, Michael C. Phillips, Chad A. Mirkin, C.Shad Thaxton   +9 more
doaj   +1 more source

ATP-binding Cassette Transporter A1 Contains an NH2-terminal Signal Anchor Sequence That Translocates the Protein's First Hydrophilic Domain to the Exoplasmic Space*

Journal of Biological Chemistry, 2001
Mutations in the ATP-binding cassette transporter A1 (ABCA1) transporter are associated with Tangier disease and a defect in cellular cholesterol efflux.
M. Fitzgerald, A. Mendez, K. Moore, L. Andersson, Hess A. Panjeton, M. Freeman   +5 more
semanticscholar   +1 more source

Impaired ATP‐binding cassette transporter A1‐mediated sterol efflux from oxidized LDL‐loaded macrophages

FEBS Letters, 2005
We investigated the interaction of oxidized low density lipoprotein (OxLDL) with the ATP‐binding cassette A1 (ABCA1) pathway in J774 macrophages. Cellular efflux to apolipoprotein AI (apo‐AI) of OxLDL‐derived cholesterol was lower than efflux of cholesterol derived from acetylated low density lipoprotein (AcLDL).
FAVARI, Elda, ZIMETTI, Francesca, BORTNICK A. E., ADORNI, Maria Pia, ZANOTTI, Ilaria, CANAVESI M., BERNINI, Franco   +6 more
openaire   +3 more sources

Moderate maternal nutrient restriction alters type II alveolar epithelial cell density in the non‐human primate fetal lung

Experimental Physiology, EarlyView.
Abstract Restriction of fetal substrate supply has an adverse effect on surfactant maturation in the lung and thus affects the transition from in utero placental oxygenation to pulmonary ventilation ex utero. However, the consequences of reduced fetal substrate supply are dependent on the timing of gestation, severity and duration.
Mitchell C. Lock, Hillary F. Huber, Cun Li, Sandra Orgeig, Peter W. Nathanielsz, Janna L. Morrison   +5 more
wiley   +1 more source