Results 91 to 100 of about 1,822,086 (171)

The ATP-binding cassette (ABC) transporter Bpt1p mediates vacuolar sequestration of glutathione conjugates in yeast.

, 2002
Vacuolar sequestration or cellular extrusion of glutathione-conjugated xenobiotics and catabolites by ATP-binding cassette (ABC) transporters is an important detoxification mechanism operating in many species.
Mamnun YM, Martinoia E, Schüller C, Wolfger H, Klein M, Kuchler K, Eggmann T   +6 more
core   +1 more source

Snapshots of the maltose transporter during ATP hydrolysis

, 2011
ATP-binding cassette transporters are powered by ATP, but the mechanism by which these transporters hydrolyze ATP is unclear. In this study, four crystal structures of the full-length wild-type maltose transporter, stabilized by adenosine 5′-
Michael L. Oldham, Jue Chen
core   +1 more source

Molecular-dynamics simulations of the ATP/apo state of a multidrug ATP-binding cassette transporter provide a structural and mechanistic basis for the asymmetric occluded state

, 2011
ATP-binding cassette transporters use the energy of ATP hydrolysis to transport substrates across cellular membranes. They have two transmembrane domains and two cytosolic nucleotide-binding domains.
Anthony M. George, Jones, PM, George, AM, Peter M. Jones   +3 more
core   +1 more source

Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations [PDF]

, 2010
CFTR, the ABC protein defective in cystic fibrosis, functions as an anion channel. Once phosphorylated by protein kinase A, a CFTR channel is opened and closed by events at its two cytosolic nucleotide binding domains (NBDs).
Gadsby, DC, Csanady, L, Vergani, P
core  

ABCB5 and the regulation of p16INK4a by non-coding RNA [PDF]

, 2014
p16INK4a (p16) traps the cell at the restriction point of the cell cycle by binding to cyclin-dependent kinase 4/6 thus preventing the phosphorylation of the retinoblastoma protein (pRB).
Braker, Paul
core  

Qige decoction ameliorates hyperlipidemia in rats by modulating the intestinal microbiota and liver metabolism. [PDF]

J Tradit Chin Med
Zunming Z, Meiao T, Xiaoqing YU, Xuehong KE, Keer H.   +4 more
europepmc   +1 more source

Cholesterol Metabolism in Cancer Patients: Mechanisms, Treatment-Related Effects, and Cardio-Oncology Management. [PDF]

Oncol Res
Piscione M, Pala B, Cribari F, Gualtieri P, Gaudio D, Perrone MA, Di Renzo L.   +6 more
europepmc   +1 more source

Leukocyte ATP-binding cassette transporter G1 gene expression is reduced in type 2 diabetes mellitus

, 2008
Leukocyte ATP-Binding Cassette Transporter G1 Gene Expression is Reduced in Type 2 Diabetes Mellitus Reverse cholesterol transport Reverse cholesterol transport is a pathway which transports cholesterol from extrahepatic cells and tissues to the liver ...
Wong, Y, Tan, KCB, Zhou, H, Shiu, SWM
core  

Fucoidan from <i>Pearsonothuria graeffei</i> alleviates dyslipidemia in ApoE^-/- mice by regulating reverse cholesterol transport and promoting bile acid synthesis. [PDF]

Front Nutr
Zhao T, Yu Y, Wang Y, Zhang L, Xiao J, Chen S, Li S.   +6 more
europepmc   +1 more source

The Molecular Mechanisms of Metformin's Action on Blood Lipid Profile in Diabetic Patients. [PDF]

Int J Mol Sci
Dettlaff-Pokora A, Swierczynski J.
europepmc   +1 more source