Results 91 to 100 of about 29,839 (226)
Several Hfq-dependent alterations in physiology of Yersinia enterocolitica O:3 are mediated by derepression of the transcriptional regulator RovM [PDF]
, 2017 In bacteria, the RNA chaperone Hfq enables pairing of small regulatory RNAs with their target mRNAs and therefore is a key player of post-transcriptional regulation network. As a global regulator, Hfq is engaged in the adaptation to external environment,
Bengoechea, José A +5 more
core +1 more source
Molecular biology of ATP citrate lyase
, 2020 The full length Arabidopsis ACL-A1 and ACL-B2 cDNAs have been expressed in E. coli. Western blot analysis of Arabidopsis extracts, probed with antiserum raised against these proteins, indicate that At.ACL-Al and At.ACL-B2 cDNAs code for proteins of 45 kDa and 65 kDa, respectively.
openaire +3 more sources
Yeast, EarlyView.ABSTRACT Given the biotechnological potential of yeast‐derived oils for oleochemical production, genes encoding lipid metabolism enzymes are key targets for metabolic engineering. Genetic engineering tools such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9, Transcription Activator‐Like Effector Nucleases (TALENs), Zinc ...
Rodrigo Gonçalves Dias +5 more
wiley +1 more source
Nature Communications, 2023 The molecular mechanisms connecting cellular metabolism with differentiation remain poorly understood. Here, we find that metabolic signals contribute to stem cell differentiation and germline homeostasis during Drosophila melanogaster spermatogenesis ...
Charlotte M. François +4 more
doaj +1 more source
Intravenous infusions of glucose stimulate key lipogenic enzymes in adipose tissue of dairy cows in a dose-dependent manner [PDF]
, 2013 The present study was investigated whether increasing amounts of glucose supply have a stimulatory effect on the mRNA abundance and activity of key lipogenic enzymes in adipose tissue of midlactation dairy cows.
Al-Trad, Bahaa +6 more
core +1 more source
ATP citrate lyase in human adipose tissue.
Journal of Nutritional Science and Vitaminology, 1981 ATP citrate lyase [EC. 4.1.3.8] activity in human adipose tissue was assayed. The activity was considerably higher in tissue from patients who had been supplied with nutrients only by intravenous injection than that from patients who had orally taken a meal and then fasted overnight.
M, Suzuki, H, Okuda
openaire +3 more sources
British Journal of Pharmacology, EarlyView.TSP4 is upregulated in human and experimental AAA. TSP4 knockdown accelerated AAA formation and exacerbated both vascular inflammation and remodelling, emphasizing that TSP4 upregulation may represent a protective response against AAA. Our findings suggest that preserving TSP4 could be a useful strategy in the clinical management of AAA.
Laia Blanco‐Casoliva +10 more
wiley +1 more source
mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis
Nature Communications, 2020 mTORC2 activates Akt, a regulator of cell growth and metabolism, however, the role of mTORC2 in adipocytes is incompletely understood. Here the authors report that a mTORC2-Akt axis specifically activates ACLY to promote lipid synthesis and histone ...
C. Martinez Calejman +12 more
doaj +1 more source
Scientific Reports, 2023 4-hydroxytamoxifen (OHT) is an anti-cancer drug that induces apoptosis in breast cancer cells. Although changes in lipid levels and mitochondrial respiration have been observed in OHT-treated cells, the overall mechanisms underlying these metabolic ...
Kazuki Nishimoto +8 more
doaj +1 more source
The HK2 Dependent "Warburg Effect" and Mitochondrial Oxidative Phosphorylation in Cancer:Targets for Effective Therapy with 3-Bromopyruvate [PDF]
, 2016 This review summarizes the current state of knowledge about the metabolism of cancer cells, especially with respect to the “Warburg” and “Crabtree” effects.
Lis, Paweł +6 more
core +3 more sources