Results 81 to 90 of about 29,839 (226)

Phosphorylation of ATP-Citrate Lyase by Nucleoside Diphosphate Kinase [PDF]

Journal of Biological Chemistry, 1995
Rat liver nucleoside diphosphate kinase (NDPK) and PC12 cell cytosol were used to determine whether NDPK could function as a protein kinase. NDPK was phosphorylated on its catalytic histidine using [gamma-32P]ATP, and the phosphorylated NDPK separated from [gamma-32P]ATP. The addition of phosphorylated NDPK to dialyzed PC12 cell cytosol resulted in the
P D, Wagner, N D, Vu
openaire   +2 more sources

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Metabolic Evolution of a Deep-Branching Hyperthermophilic Chemoautotrophic Bacterium [PDF]

, 2013
Aquifex aeolicus is a deep-branching hyperthermophilic chemoautotrophic bacterium restricted to hydrothermal vents and hot springs. These characteristics make it an excellent model system for studying the early evolution of metabolism.
Braakman, Rogier, Smith, Eric
core   +4 more sources

ATP-citrate lyase kinase and cyclic AMP-dependent protein kinase phosphorylate different sites on ATP-citrate lyase.

Journal of Biological Chemistry, 1981
ATP-citrate lyase was phosphorylated by highly purified cyclic AMP-independent protein kinase (ATP-citrate lyase kinase) or the catalytic subunit of cyclic AMP-dependent protein kinase. Each kinase phosphorylated ATP-citrate lyase equally but the combination of both kinases increased ATP-citrate lyase phosphorylation additively.
S, Ramakrishna, D L, Pucci, W B, Benjamin   +2 more
openaire   +2 more sources

Inflammation, Immunity, and Cardiovascular Diseases

Med Research, EarlyView.
Cardiovascular stress signals (e.g., hemodynamic shear, oxidized lipids, and ischemia) act on endothelial and immune cells to activate and amplify inflammation through NF‐κB, the NLRP3 inflammasome, and JAK/STAT signaling, inducing proinflammatory cytokines/chemokines (IL‐6, IL‐1β, TNF‐α, and CCL2) and self‐amplifying circuits; clinically, inflammatory
Dezhi Guo, Yan Liao, Rui Zhao, Zhaoyu Li, Kaikai Wang, Haoling Zhang, Pingxin Sun, Yadong Guo, Wangzheqi Zhang   +8 more
wiley   +1 more source

Energy metabolism of Heliobacterium modesticaldum during phototrophic and chemotrophic growth [PDF]

, 2010
Background Heliobacterium modesticaldum is a gram-positive nitrogen-fixing phototrophic bacterium that can grow either photoheterotrophically or chemotrophically but not photoautotrophically.
Kuo-Hsiang Tang, Hai Yue, Robert E Blankenship   +2 more
core   +1 more source

Uric Acid in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Portal Hypertension &Cirrhosis, EarlyView.
MASLD is the most prevalent chronic liver disease worldwide, yet effective pharmacological treatments remain limited. Hyperuricemia is now recognized as a key driver of hepatic steatosis, inflammation, and fibrosis, with elevated serum uric acid levels independently predicting hepatocellular carcinoma and liver‐related mortality.
Rong Wang, Zhenyu Liu, Jun Lin, Weijing Zhang, Xianzhi Liu, Tong Zhang   +5 more
wiley   +1 more source

Effects of sex and site on amino acid metabolism enzyme gene expression and activity in rat white adipose tissue [PDF]

, 2016
Podeu consultar dades primàries associades a l'article a: http://hdl.handle.net/2445/66872Background and Objectives.White adipose tissue (WAT) shows marked sex- and diet-dependent differences.However, our metabolic knowledge ofWAT, especially on amino ...
Agnelli, Silvia, Alemany, Marià, 1946-, Arriarán, Sofía, Fernández López, José Antonio, Remesar Betlloch, Xavier   +4 more
core   +1 more source

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase

Frontiers in Immunology, 2018
Macrophages exposed to the Th2 cytokines interleukin (IL) IL-4 and IL-13 exhibit a distinct transcriptional response, commonly referred to as M2 polarization.
Dmitry Namgaladze, Sven Zukunft, Frank Schnütgen, Nina Kurrle, Ingrid Fleming, Dominik Fuhrmann, Bernhard Brüne, Bernhard Brüne   +7 more
doaj   +1 more source