Results 71 to 80 of about 30,215 (258)

Oncometabolites: tailoring our genes [PDF]

, 2015
Increased glucose metabolism in cancer cells is a phenomenon that has been known for over 90 years, allowing maximal cell growth through faster ATP production and redistribution of carbons towards nucleotide, protein and fatty acid synthesis.
Avril N, Buck AC, Gimm O, Higashi K
core   +1 more source

The role of the gut microbiome in the regulation of high‐altitude adaptation

iMeta, EarlyView.
This study is the first to elucidate mechanisms of high‐altitude adaptation from the perspective of the rumen ecosystem by using indigenous yaks and Holstein cows that have lived at high altitude since birth as comparative models. Through a systematic comparison of their rumen ecology using multi‐omics approaches—including rumen metagenomics ...
Xinyu Zhang, Senlin Zhu, Michael Kreuzer, Shoukun Ji, Wei Wang, Yanliang Bi, Shengli Li   +6 more
wiley   +1 more source

Supplementary Figure Legend from ATP Citrate Lyase Knockdown Induces Growth Arrest and Apoptosis through Different Cell- and Environment-Dependent Mechanisms [PDF]

, 2023
Nousheen Zaidi, Inès Royaux, Johannes V. Swinnen, Karine Smans   +3 more
openalex   +2 more sources

Genetic and biochemical analyses of chromosome and plasmid gene homologues encoding ICL and ArCP domains in Vibrioanguillarum strain 775 [PDF]

, 2011
Anguibactin, the siderophore produced by Vibrio anguillarum 775 is synthesized from 2,3-dihydroxybenzoic acid (DHBA), cysteine and hydroxyhistamine via a nonribosomal peptide synthetase (NRPS) mechanism.
AF Alice, AM Gehring, B Schwyn, C Notredame, CG Marshall, DH Figurski, EJ Drake, EL Arnow, F Bolivar, F Rusnak, H Naka, HW Boyer, J Frey, J Sambrook, JF Parsons, JF Staab, JH Crosa, JH Crosa, Jorge H. Crosa, JR Lai, JR Pollack, KA Datsenko, LA Actis, LA Actis, LE Quadri, M Balado, M Di Lorenzo, M Di Lorenzo, M Di Lorenzo, M Hahn, M Jalal, M Stork, MA Walter, Manuela Di Lorenzo, ME Tolmasky, ME Tolmasky, Michiel Stork, MK Wolf, PA Bates, Q Chen, RF Conchas, SF Altschul, TA Keating, TJ Welch   +43 more
core   +2 more sources

Enteral and intravenous supplementation of arginine and citrulline fail to prevent necrotizing enterocolitis in preterm neonatal pigs

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in preterm infants with a morality rate that approaches 50%. Arginine has been widely studied in the field of clinical nutrition as a supplement for patients experiencing critical illness because it can be metabolized into nitric oxide, an important agent ...
Caitlin Vonderohe, Julia Garcia Mancebo, Valeria Melendez Hebib, Barbara Stoll, Inka Didelija, Sarah Elefson, Mahmoud Mohammad, Brooklynn Earls, Greg Guthrie, Doug Burrin   +9 more
wiley   +1 more source

ATP-Citrate Lyase: A Key Player in Cancer Metabolism [PDF]

Cancer Research, 2012
Abstract ATP-citrate lyase (ACLY) is a cytosolic enzyme that catalyzes the generation of acetyl CoA from citrate. Acetyl CoA is a vital building block for the endogenous biosynthesis of fatty acids and cholesterol and is involved in isoprenoid-based protein modifications.
Nousheen, Zaidi, Johannes V, Swinnen, Karine, Smans   +2 more
openaire   +2 more sources

Rhizosphere microbial detoxification and phosphorus solubilization drive ecological remediation of Pb–Zn contaminated soils

PLANTS, PEOPLE, PLANET, EarlyView.
Heavy metal contamination of soils poses a serious threat to ecosystem health and food security worldwide. This study investigated how native plants, such as Artemisia annua and Buddleja davidii, interact with soil microbes in Pb–Zn waste slag areas. We found that these plants stimulate microbes, which improve phosphorus availability and reduce metal ...
Caili Sun, Yajuan Yao, Yongwei Liu, Xiaoyu Lu   +3 more
wiley   +1 more source

Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity [PDF]

, 2014
The majority of oligodendrogliomas (ODGs) exhibit combined losses of chromosomes 1p and 19q and mutations of isocitrate dehydrogenase (IDH1-R132H or IDH2-R172K).
Blough, Michael D., Cairncross, J. Gregory, Chan, Jennifer A., Chan, Susanna, Chen, Vincent, Chittaranjan, Suganthi, Firme, Marlo, Go, Nancy E., Gorski, Sharon M., Marra, Marco A., Moradian, Annie, Morin, Gregg B., Song, Jungeun, Yang, Cindy, Yang, Kevin C., Yip, Stephen   +15 more
core   +2 more sources

ATP citrate lyase: A central metabolic enzyme in cancer

Cancer Letters, 2020
ACLY links energy metabolism provided by catabolic pathways to biosynthesis. ACLY, which has been found to be overexpressed in many cancers, converts citrate into acetyl-CoA and OAA. The first of these molecules supports protein acetylation, in particular that of histone, and de novo lipid synthesis, and the last one sustains the production of ...
Icard, Philippe, Wu, Zherui, Fournel, Ludovic, Coquerel, Antoine, Lincet, Hubert, Alifano, Marco   +5 more
openaire   +4 more sources

Vegetal residue‐based formulation of Trichoderma ossianense, a new indigenous vineyard species adapted to alkaline pH with potential biocontrol ability against Black‐foot disease pathogens

Pest Management Science, EarlyView.
The study identifies Trichoderma ossianense, was can be isolated from grapevine roots, is capable of growing at alkaline pH and controls black‐foot pathogens, highlighting the vegetal residue‐based formulations that preserve its viability. Abstract BACKGROUND Fungi of the Trichoderma genus are used in vineyards as biological control agents mainly ...
Laura Zanfaño, Guzmán Carro‐Huerga, Álvaro Rodríguez‐González, Sara Mayo‐Prieto, Daniela Ramírez‐Lozano, Rosa E Cardoza, Santiago Gutiérrez, Pedro A Casquero   +7 more
wiley   +1 more source