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Effect of SJAMP on ATP release of platelet
Current Medical Science, 1999The aggregation and ATP release of placelet of normal subjects were measured by platelet lumi-aggregometer. It was found that the aggregation curve induced by SJAMP at the concentration of 100 mg/L was a typical second phase aggregation. There existed a certain lag between platelet aggregation and secretion.
T, Guo, D, Shen, S, Song, W, Wei
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Characteristics of neuronal release of ATP
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1984Recent studies have described a transmitter-like release of ATP in brain. Once released, extraneuronal ATP is rapidly metabolized to adenosine by ecto-ATPase and nucleotidase. Adenosine, through actions at specific receptors, inhibits neuronal firing in the brain.
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Clodronate: A Vesicular ATP Release Blocker
Trends in Pharmacological Sciences, 2018Clodronate is a first-generation bisphosphonate used worldwide for antiresorptive therapy for osteoporosis. Although clodronate is analgesic in nature, its mechanism and efficacy were unknown for some time. Recently, clodronate was identified as a selective and potent inhibitor for vesicular nucleotide transporter (VNUT), a transporter responsible for ...
Yoshinori, Moriyama, Masatoshi, Nomura
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Detecting ATP Release by a Biosensor Method
Science's STKE, 2004Cells release adenosine 5′-triphosphate (ATP) into the extracellular space in response to various stimuli. This released ATP plays an important physiological role in cell-to-cell signal transduction. The bulk ATP concentration can be detected using a conventional luciferin-luciferase assay. However, the ATP concentration in the vicinity of
Seiji, Hayashi +4 more
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2012
For all its complexity, the brain can be broadly divided into two major types of cells, neurons and glial cells. Glia are defined as nonneuronal cells and function to maintain homeostasis, form myelin, and provide support and protection for neurons. Formerly thought to be passive support cells, we now know that astrocytes, the major subtype of glial ...
Dustin J. Hines, Philip G. Haydon
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For all its complexity, the brain can be broadly divided into two major types of cells, neurons and glial cells. Glia are defined as nonneuronal cells and function to maintain homeostasis, form myelin, and provide support and protection for neurons. Formerly thought to be passive support cells, we now know that astrocytes, the major subtype of glial ...
Dustin J. Hines, Philip G. Haydon
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Actin mediated release of ATP from a myosin ATP complex
Biochemistry, 1978The apparent second-order rate constant, ka-2, of actin binding to a myosin-ATP state (M*.ATP) and releasing ATP to the medium has been determined by two methods. The first was the measurement of the amount of ATP released when actin was added to the intermediate state, M*.ATP; the second was the measurement of oxygen exchange between ATP and HOH.
J A, Sleep, R L, Hutton
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Microglia release ATP by exocytosis.
Glia, 2014Microglia survey the brain environment by sensing several types of diffusible molecules, among which extracellular nucleotides released/leaked from damaged cells have central roles. Microglia sense ATP or other nucleotides by multiple P2 receptors, after which they change into several different phenotypes. However, so far, it is largely unknown whether
Yoshio, Imura +8 more
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ATP release and effects in pancreas
Drug Development Research, 2003AbstractATP and other nucleotides are released from various cells, but the pathway and physiological stimulus for ATP release are often unclear. The focus of our studies is the understanding of ATP release and signaling in rat exocrine pancreas. In acinar suspension mechanical stimulation, hypotonic shock and, most importantly, cholinergic stimulation ...
Novak, Ivana +4 more
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Optogenetic control of ATP release
SPIE Proceedings, 2013Controlled release of ATP can be used for understanding extracellular purinergic signaling. While coarse mechanical forces and hypotonic stimulation have been utilized in the past to initiate ATP release from cells, these methods are neither spatially accurate nor temporally precise.
Matthew A. Lewis +4 more
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Release of adenosine and lack of release of ATP from contracting skeletal muscle
Pfl�gers Archiv European Journal of Physiology, 1975Adenosine triphosphate (ATP) has been suggested as a mediator of active hyperemia and its levels have been reported to increase in the venous plasma from contracting skeletal muscle. However, the source of the ATP is unknown. The present study indicates that a large portion of the plasma ATP is released from the formed elements of blood when the blood ...
E L, Bockman, R M, Berne, R, Rubio
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