Results 201 to 210 of about 191,822 (304)

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Fragments of ATP synthase mediate plant perception of insect attack

, 2006
Eric A. Schmelz, Mark J. Carroll, Sherry LeClere, Stephen M. Phipps, Julia A. Meredith, Prem S. Chourey, Hans T. Alborn, Peter E. A. Teal   +7 more
openalex   +1 more source

Cardiolipin acyl chain composition tailors the conformation of mammalian ATP synthase dimers. [PDF]

Commun Chem
Makowski M, Almendro-Vedia VG, López-Montero I.   +2 more
europepmc   +1 more source

Microprotein MP104 Promotes Malignant Progression of Colorectal Cancer Through Regulating Protein Translation

Advanced Science, EarlyView.
A previously unrecognized microprotein, MP104, encoded by ZEB1‐AS1, emerges as a critical driver of colorectal cancer progression. MP104 links ubiquitin‐mediated protein degradation with translational reprogramming via the UBE2O–AMPKα2–mTOR–EIF4B axis, revealing an unrecognized layer of oncogenic regulation.
Fang Chen, Miao Wang, Hongmei Yong, Jin Ding, Shiping Xu, Qirui Ge, Yan Wang, Lei Zhang, Qianqian Xiao, Benli Li, Li Lin, Sufang Chu, Qianqing Wang, Jin Bai, Pingfu Hou   +14 more
wiley   +1 more source

The molecular mechanism of ATP synthase constrains the evolutionary landscape of chemiosmosis. [PDF]

Biophys J
Macdonald JE, Ashby PD.
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Sequential Immune Acquisition of Monoclonal Antibodies Enhances Phagocytosis of Acinetobacter baumannii by Recognizing ATP Synthase

Dong Huang, Zhujun Zeng, Zhuolin Li, Mengjun Li, Linlin Zhai, Yuhao Lin, Rui Xu, Jiuxin Qu, Bao Zhang, Wei Zhao, Chenguang Shen   +10 more
openalex   +1 more source

When opposites compensate: proton flux crosstalk between envelope antiporters and ATP synthase. [PDF]

Plant Physiol
Singh R.
europepmc   +1 more source

Programmable Encapsulation Enables On‐Demand Proliferation of Therapeutic Bacteria for Potent Cancer Immunotherapy

Advanced Science, EarlyView.
A programmable encapsulation technology is developed to reduce bacterial immunogenicity and proliferation after systemic administration. The cross‐linked polymer networks around individual bacteria enable immunogenic shielding and permit selective proliferation in tumors, allowing the bacteria to convert tumor‐accumulated ammonia into L‐arginine and ...
Jianhui Yang, Ao Peng, Shuaiqiang Li, Yaning Huang, Jian Yan, Leyuan Wang, Zhihui Zhu, Fei‐Long Liu, Erbao Bian, Yang Liu, Dasheng Tian, Fenghe Li, Qi Liu   +12 more
wiley   +1 more source

Synthesis and Evaluation of Pyridine-Based Antibacterial Agents that Inhibit ATP Synthase in <i>Acinetobacter baumannii</i>. [PDF]

ACS Omega
Dennison AL, Singh A, Marchlewski TA, Ghee SN, Gencel KC, Hammock AG, Liu S, Wilson S, Williams APL, Ward KT, Meigs TE, Steed PR, Wolfe AL.   +12 more
europepmc   +1 more source