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Structure of the human ATP synthase

Molecular Cell, 2023
Biological energy currency ATP is produced by F1Fo-ATP synthase. However, the molecular mechanism for human ATP synthase action remains unknown. Here, we present snapshot images for three main rotational states and one substate of human ATP synthase using cryoelectron microscopy. These structures reveal that the release of ADP occurs when the β subunit
Zhanqiang Du
exaly   +5 more sources

Phomoxanthone A Targets ATP Synthase

Chemistry – A European Journal, 2022
AbstractPhomoxanthone A is a naturally occurring molecule and a powerful anti‐cancer agent, although its mechanism of action is unknown. To facilitate the determination of its biological target(s), we used affinity‐based labelling using a phomoxanthone A probe. Labelled proteins were pulled down, subjected to chemoproteomics analysis using LC‐MS/MS and
Rameez Ali   +8 more
openaire   +3 more sources

ATP Synthase

Annual Review of Biochemistry, 2015
Oxygenic photosynthesis is the principal converter of sunlight into chemical energy. Cyanobacteria and plants provide aerobic life with oxygen, food, fuel, fibers, and platform chemicals. Four multisubunit membrane proteins are involved: photosystem I (PSI), photosystem II (PSII), cytochrome b6f (cyt b6f), and ATP synthase (FOF1).
Wolfgang, Junge, Nathan, Nelson
openaire   +2 more sources

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