Results 281 to 290 of about 837,065 (393)

Dimers of mitochondrial ATP synthase form the permeability transition pore

Proceedings of the National Academy of Sciences of the United States of America, 2013
V. Giorgio, Sophia von Stockum, Manuela Antoniel, A. Fabbro, F. Fogolari, M. Forte, G. Glick, V. Petronilli, M. Zoratti, I. Szabó, G. Lippe, P. Bernardi   +11 more
semanticscholar   +1 more source

Gigaxonin Potentiates Antiviral Innate Immune Responses by Targeting cGAS and TREX1

Advanced Science, EarlyView.
TREX1 antagonizes DNA sensor cGAS by degrading cytosolic DNA. This work identifies gigaxonin as a molecular switch that coordinates DNA sensing and clearance pathways to amplify antiviral responses. Under the steady state, gigaxonin maintains cellular homeostasis by mediating TREX1 ubiquitination and proteasomal degradation. During DNA virus infection,
Ben‐Zhe Ji, Jie Wang, Yi Tu, Shan Zhang, Yong‐Sheng Wei, Yan He, Bin Zhang, Qing‐Qing Zhao, Hao‐Min Hu, Yu Liu   +9 more
wiley   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Glutamate residues at positions 219 and 252 in the a-subunit of the Escherichia coli ATP synthase are not functionally equivalent

, 1998
Lyndall Hatch, G B Cox, Susan M. Howitt
openalex   +1 more source

Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS‐NADPH Dysregulation

Advanced Science, EarlyView.
Se deficiency downregulates SELENOT, disrupting mitochondrial function and elevating mtROS to induce glucose metabolic reprogramming, NADPH depletion, cysteine accumulation, and disulfidptosis‐mediated actin cytoskeleton collapse in chicken skeletal muscle.
Huanyi Liu, Hao Wu, Ziyu Zhang, Shiwen Xu, Cong Zhou, Tong Xu   +5 more
wiley   +1 more source

Rotation-Direction-Dependent Mechanism of the Inhibitor Protein IF₁ for Mitochondrial ATP Synthase from Atomistic Simulations. [PDF]

JACS Au
Kobayashi R, Okazaki KI.
europepmc   +1 more source

The ATP synthase of Streptomyces lividans: characterization and purification of the F1Fo complex

, 1996
Michael Hensel, Heike Achmus, Gabriele Deckers‐Hebestreit, Karlheinz Altendorf   +3 more
openalex   +1 more source

High-resolution cryo-EM analysis of the yeast ATP synthase in a lipid membrane

Science, 2018
A. Srivastava, M. Luo, Wenchang Zhou, J. Symerský, Dongyang Bai, M. Chambers, J. Faraldo-Gómez, M. Liao, D. Mueller   +8 more
semanticscholar   +1 more source

SIP‐SRS Imaging of Cell Wall Synthesis Identifies a Synergy between Micafungin and Amphotericin B

Advanced Science, EarlyView.
We employed glucose‐d7–based stable isotope probe‐assisted SRS microscopy (SIP‐SRS) C–D imaging to visualize fungal cell wall synthesis and remodeling under antifungal treatment. Amphotericin B (AmB) induced notable daughter cell wall thickening, prompting a combinational therapy with AmB and micafungin.
Meng Zhang, Yuewei Zhan, Haonan Lin, Jiyang Chen, Mohamed N. Seleem, Michael Mansour, Ji‐Xin Cheng   +6 more
wiley   +1 more source

Quinoline ATP Synthase Inhibitors with Activity Against Multidrug Resistant Acinetobacter baumannii and Pseudomonas aeruginosa. [PDF]

ChemMedChem
Ward KT, Williams APL, Dennison AL, Aamir L, Allen DL, Chavez-Arellano B, Marchlewski TA, Zappia ML, Wolfe AL, Steed PR.   +9 more
europepmc   +1 more source