Results 91 to 100 of about 547,455 (357)

A New 3D Colon on a Chip to Decipher the Influence of Mechanical Forces on the Physiological Cellular Ecosystem

Advanced Healthcare Materials, EarlyView.
To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery, Lauriane Gérémie, Julie Brun, Lucas Chassatte, Giacomo Gropplero, Réda Bouras, Jieun Choo, Bertrand Cinquin, Alba Marcellan, Danijela Matic Vignjevic, Stéphanie Descroix   +10 more
wiley   +1 more source

The curious case of vacuolar ATPase: regulation of signaling pathways

Molecular Cancer, 2018
The Vacuolar ATPase (V-ATPase) is a proton pump responsible for controlling the intracellular and extracellular pH of cells. The structure of V-ATPase has been highly conserved among all eukaryotic cells and is involved in diverse functions across ...
Sahithi Pamarthy, Arpita Kulshrestha, Gajendra K. Katara, Kenneth D. Beaman   +3 more
doaj   +1 more source

The evolution of energy-transducing systems. Studies with an extremely halophilic archaebacterium [PDF]

The halobacterial ATPase was labeled with C-14-dicyclohexylcarbodiimide and subunit 2 of the enzyme was prepared by electroelution. Subunit 2 was cleaved by several chemical and enzymatic procedures for further preparation of peptides.
Stan-Lotter, Helga
core   +1 more source

The Space Within: How Architected Voids Promote Tissue Formation

Advanced Materials, EarlyView.
This review explores the role of void spaces in tissue engineering scaffolds and examines four key methods for introducing porosity into hydrogels at different scales. It discusses sacrificial templating, microgels, phase separation, and 3D printing, highlighting principles, advantages, and limitations. It also addresses emerging strategies integrating
Anna Puiggalí‐Jou, Isabel B. Hui, Carla Fernandez‐Rico, Marcy Zenobi‐Wong   +3 more
wiley   +1 more source

Na+/K+-ATPase: ion pump, signal transducer, or cytoprotective protein, and novel biological functions

Neural Regeneration Research
Na+/K+-ATPase is a transmembrane protein that has important roles in the maintenance of electrochemical gradients across cell membranes by transporting three Na+ out of and two K+ into cells.
Songqiang Huang, Wanting Dong, Xiaoqian Lin, Jinsong Bian   +3 more
doaj   +1 more source

Control of calcium homeostasis in Schistosoma mansoni

Memorias do Instituto Oswaldo Cruz, 2001
Calcium signalling is fundamental for muscular contractility of Schistosoma mansoni. We have previously described the presence of transport ATPases (Na+,K+-ATPase and (Ca2+-Mg2+)-ATPase) and calcium channels (ryanodine receptors - RyR) involved in ...
F Noël, VMN Cunha, CLM Silva, DL Mendonça-Silva   +3 more
doaj   +1 more source

MYB308-mediated transcriptional activation of plasma membrane H+-ATPase 6 promotes iron uptake in citrus [PDF]

, 2022
Zhengyan Fan, Yi‐Fang Wu, Liuying Zhao, Lina Fu, Lile Deng, Jiarui Deng, Dekuan Ding, Shunyuan Xiao, Xiuxin Deng, Shuang Peng, Zhiyong Pan   +10 more
openalex   +1 more source

Select pyrimidinones inhibit the propagation of the malarial parasite, Plasmodium falciparum [PDF]

, 2009
Plasmodium falciparum, the Apicomplexan parasite that is responsible for the most lethal forms of human malaria, is exposed to radically different environments and stress factors during its complex lifecycle.
Annette N. Chiang, Banumathy, Billy W. Day, Botha, Brian P. Mead, Chiu, Corinne Schneider, Craig, David A. Fidock, Donna M. Huryn, Ekland, Fernandez-Saiz, Fewell, Fewell, Fewell, Fidock, Frydman, Hartl, Hunt, Jeffrey L. Brodsky, Jiang, Juan-Carlos Valderramos, Maier, Matambo, Mayer, McClellan, McKerrow, Michael G. Klein, Midorikawa, Nadeau, Noedl, Pavithra, Pecoul, Peter Wipf, Raghavan Balachandran, Raj J. Chovatiya, Ramya, Rodina, Samantha L. Bell, Shonhai, Shonhai, Sidhu, Tang, Tonkin, Wellems, Werner, Wright, Xiaojiang S. Chen, Youker   +48 more
core   +1 more source

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

V-ATPase Dysfunction in the Brain: Genetic Insights and Therapeutic Opportunities

Cells
Vacuolar-type ATPase (v-ATPase) is a multimeric protein complex that regulates H+ transport across membranes and intra-cellular organelle acidification. Catabolic processes, such as endocytic degradation and autophagy, strictly rely on v-ATPase-dependent
Antonio Falace, Greta Volpedo, Marcello Scala, Federico Zara, Pasquale Striano, Anna Fassio   +5 more
doaj   +1 more source