Results 51 to 60 of about 493,727 (307)

Versatility of NaCl transport mechanisms in the cortical collecting duct [PDF]

, 2017
Versatility of NaCl transport mechanisms in the cortical collecting duct. Am J Physiol Renal Physiol 313: F1254 –F1263, 2017. First published September 6, 2017; doi:10.1152/ajprenal.00369.2017.—The cortical collecting duct (CCD) forms part of the ...
Crambert, Gilles, Edwards, Aurelie
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Single Strand Annealing and ATP-independent Strand Exchange Activities of Yeast and Human DNA2: possible role in Ozaki fragment maturation [PDF]

, 2006
The Dna2 protein is a multifunctional enzyme with 5'-3' DNA helicase, DNA-dependent ATPase, 3' exo/endonuclease, and 5' exo/endonuclease. The enzyme is highly specific for structures containing single-stranded flaps adjacent to duplex regions.
Campbell, Judith L., Masuda-Sasa, Taro, Polaczek, Piotr   +2 more
core  

DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation [PDF]

, 2015
The acquisition of endocrine therapy resistance in estrogen receptor a (ERa) breast cancer patients represents a major clinical problem. Notch signalling has been extensively linked to breast cancer especially in patients who fail to respond to endocrine
Aifantis, Apatira, Apweiler, Brennan, Carroll, Chazotte, Chen, Coombes, Darbre, Eikesdal, Forgac, Goloubeva, Gul, Hill, Ho, Joffe, Johnston, Jones, Jones, Jones, Kane, Kang, Kocak, Lake, Le Borgne, Lendahl, Liu, Lupien, Mader, Mao, Martinez, McPherson, Medici, Meyer, Miele, Miele, Miele, Miyamoto, Nguyen, Nicolson, Roegiers, Sarkar, Schiff, Schilling, Schupbach, Sutherland, Taylor, Urbe, Vaccari, Venkanteshan, Wang, Webster, Wieczorek, Wong, Zahler   +54 more
core   +3 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Enhanced expression of vacuolar H+-ATPase subunit E in the roots is associated with the adaptation of Broussonetia papyrifera to salt stress. [PDF]

PLoS ONE, 2012
Vacuolar H(+)-ATPase (V-H(+)-ATPase) may play a pivotal role in maintenance of ion homeostasis inside plant cells. In the present study, the expression of V-H(+)-ATPase genes was analyzed in the roots and leaves of a woody plant, Broussonetia papyrifera,
Min Zhang, Yanming Fang, Zhenhai Liang, Libin Huang   +3 more
doaj   +1 more source

Apical endosomes isolated from kidney collecting duct principal cells lack subunits of the proton pumping ATPase. [PDF]

, 1992
Endocytic vesicles that are involved in the vasopressin-stimulated recycling of water channels to and from the apical membrane of kidney collecting duct principal cells were isolated from rat renal papilla by differential and Percoll density gradient ...
Ausiello, DA, Brown, D, Gluck, S, Sabolić, I, Shi, LB, Verkman, AS, Wuarin, F   +6 more
core  

A P-type ATPase importer that discriminates between essential and toxic transition metals [PDF]

, 2009
Transition metals, although being essential cofactors in many physiological processes, are toxic at elevated concentrations. Among the membrane-embedded transport proteins that maintain appropriate intracellular levels of transition metals are ATP-driven
A. T. Lee, Agranoff, Arguello, Arg  ello, Axelsen, Bal, Bull, D. C. Rees, Finney, Francis, Grass, Johnson, Krogh, Legatzki, Lewinson, Melchers, Nies, O. Lewinson, Papp-Wallace, Phung, Rensing, Schafer, Sharma, Thompson, Trenor, Vulpe   +25 more
core   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Expression of a prokaryotic P-type ATPase in E. coli Plasma Membranes and Purification by Ni²⁺-affinity chromatography

Biological Procedures Online, 1998
In order to characterize the P-type ATPase from Synechocystis 6803 [Geisler (1993) et al. J. Mol. Biol. 234, 1284] and to facilitate its purification, we expressed an N-terminal 6xHis-tagged version of the ATPase in an ATPase deficient E.
Geisler Markus
doaj   +1 more source