Results 51 to 60 of about 10,287 (223)

Medications That Regulate Pregnane X Receptor: A Systematic Review of Current Evidence

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
PRISMA 2020 flow diagram of study selection for this systematic review of medications that regulate the pregnane X receptor (PXR), from 12 236 records screened to 101 included studies. ABSTRACT The pregnane X receptor (PXR) gene encodes a ligand‐activated protein involved with the metabolism and excretion of drugs, toxins, and other xenobiotics.
Petra Czarniak, Rachael Moorin, Jeff Hughes, Karl Gruber, David Youens   +4 more
wiley   +1 more source

Effect of Tokishakuyakusan on Anemia in a Rat Model of Salt‐Sensitive Hypertension

Traditional &Kampo Medicine, Volume 13, Issue 2, August 2026.
ABSTRACT Aim Anemia is prevalent in patients with cardiac and renal diseases and is associated with morbidity and mortality. Consequently, new strategies for managing anemia are expected in these patients. Tokishakuyakusan, a Kampo medicine, is clinically used to treat various conditions, such as anemia and chronic nephritis.
Yoshiro Naito, Takeshi Tsujino, Masanori Asakura, Masaharu Ishihara   +3 more
wiley   +1 more source

Study on the mechanism of Atractylodes macrocephala extract regulating mitochondrial endoplasmic reticulum stress through PI3K/Akt signaling pathway to reverse epithelial-mesenchymal transition in uterine fibroids

Pakistan Journal of Pharmaceutical Sciences
Background: Uterine fibroids involve abnormal cell proliferation and fibrosis, with epithelial-mesenchymal transition (EMT) playing a key role. Mitochondrial-endoplasmic reticulum stress and related signaling pathways are implicated in this process, but ...
Ling Huang, Tao Wang, Li Chen, Lei Shi
doaj   +1 more source

Effects of Atractylodes Macrocephala Rhizoma polysaccharide on intestinal microbiota composition in rats with mammary gland hyperplasia

Frontiers in Endocrinology, 2023
BackgroundIn recent years, mammary gland hyperplasia (MGH) has been considered to be one of the diseases caused by endocrine disorders. It has been shown that diseases caused by endocrine disorders can be treated by regulating intestinal microbial.
Yang Ping, Changxu Li, Lihong Wang, Hong Zhao   +3 more
doaj   +1 more source

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, Volume 2, Issue 3, July 2026.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

Anti-Tumor Activity of Atractylenolide I in Human Colon Adenocarcinoma In Vitro

Molecules, 2020
Atractylodes macrocephala is known to exhibit multi-arrays of biologic activity in vitro. However, detail of its anti-tumor activity is lacking. In this study, the effects of atractylenolide I (AT-I), a bio-active compound present in Atractylodes ...
Ka Woon Karen Chan, Hau Yin Chung, Wing Shing Ho   +2 more
doaj   +1 more source

Amelioration of Non-Alcoholic Steatohepatitis by Atractylodes macrocephala Polysaccharide, Chlorogenic Acid, and Geniposide Combination Is Associated With Reducing Endotoxin Gut Leakage

Frontiers in Cellular and Infection Microbiology, 2022
Gut-derived lipopolysaccharide (LPS) leaking through the dysfunctional intestinal barrier contributes to the onset of non-alcoholic steatohepatitis (NASH) by triggering inflammation in the liver.
Jing Leng, Jing Leng, Jing Leng, Jing Leng, Hua-jie Tian, Hua-jie Tian, Hua-jie Tian, Yi Fang, Yi Fang, Yi Fang, Yi-yang Hu, Yi-yang Hu, Yi-yang Hu, Yi-yang Hu, Jing-hua Peng, Jing-hua Peng, Jing-hua Peng   +16 more
doaj   +1 more source

Large‐Scale Evaluation of Traditional Chinese Medicines Reveals Potential PPARγ Modulators for Type 2 Diabetes Management

Journal of Clinical Laboratory Analysis, Volume 40, Issue 12, June 2026.
Identifying novel treatments for diabetic management is always a competitive research topic all over the world. PPAR‐γ is one of the key regulators involved in glucose and lipid metabolism and improves insulin sensitivity and glucose homeostasis. This study investigated the impacts of 639 traditional Chinese medicine (TCM) on PPAR‐γ gene promoter ...
Mingyuan Dou, Shandra Jones, Juan Montes, Jonathan Ritter, Li‐Yu Shih, Chia‐Jung Chan, Ying‐Chou Lin, Min Chen, Shih‐Yin Chen, Ning Wu   +9 more
wiley   +1 more source

Evaluation of Storage Conditions and Pre‐Treatment Methods to Mitigate Aflatoxin Contamination in Commonly Used Chinese Herbal Medicines

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
High temperature and humidity significantly promote aflatoxin contamination in herbal medicines. This research demonstrates that drying, vacuum packaging, and sulfur fumigation are effective strategies to minimize contamination and extend shelf life, whereas UV exposure proves ineffective for decontamination.
Tung Leong Fong, Tingyuan Xing, Yau‐Tuen Chan, Zixin Feng, Guoyi Tang, Yibin Feng, Cheng Zhang, Ning Wang   +7 more
wiley   +1 more source

Efficacy and safety of Atractylodes macrocephala-containing traditional Chinese medicine combined with neoadjuvant chemotherapy in the treatment of advanced gastric cancer: a systematic evaluation and meta-analysis

Frontiers in Oncology
BackgroundIn China, Atractylodes-containing Chinese medicines are widely used as adjuvant therapy to neoadjuvant chemotherapy (NAC) in individuals diagnosed with advanced gastric cancer (AGC).
Xiaotao Niu, Xiaotao Niu, Haoqing Gu, Haoqing Gu, Jingzhan Li, Jingzhan Li, Jiaqian Zuo, Jiaqian Zuo, Wenqin Ren, Wenqin Ren, Yujie Huang, Yujie Huang, Xinyan Shu, Xinyan Shu, Chao Jiang, Chao Jiang, Peng Shu, Peng Shu   +17 more
doaj   +1 more source