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Interactions between atrial fibrosis and inflammation in atrial fibrillation [PDF]

Frontiers in Cardiovascular Medicine
Atrial fibrillation (AF) is a complex arrhythmia driven by intricate pathophysiological mechanisms, with atrial fibrosis and inflammation emerging as central players in its initiation and perpetuation. Key pathways, including the renin-angiotensin-aldosterone system (RAAS), TGF-β/Smad signaling, and pro-inflammatory cytokine cascades (e.g., TNF-α/NF-κB,
Zhihua Pang
exaly   +5 more sources

Cardiac magnetic resonance imaging-derived atrial fibrosis in patients with pre-atrial fibrillation [PDF]

Open Heart
Introduction Atrial fibrosis identified on cardiac magnetic resonance (CMR) imaging has been proposed as a preprocedural imaging biomarker for patient selection for rhythm control interventions in patients with atrial fibrillation (AF).
Gregory Y H Lip, Chris P Gale, Sven Plein, Jianhua Wu, Peter Swoboda, Ramesh Nadarajah, Catherine Reynolds, Ali Wahab, John Camm, Wasim Javed, Asad Bhatty, Raluca Tomoaia, Sheena Bennet   +12 more
doaj   +2 more sources

Assessment of atrial fibrosis for the rhythm control of atrial fibrillation [PDF]

International Journal of Cardiology, 2016
Rhythm control of atrial fibrillation (AF) remains challenging, with modest long-term success rates. Atrial fibrosis has been associated with AF, but the clinical utility of assessment of this fibrosis has yet to be fully elucidated. In this paper we review the current state of understanding of the pathophysiology of atrial fibrosis in AF, and its ...
Gordon Begg, Sven Plein
exaly   +4 more sources

ATRIAL FIBROSIS IS A MORPHOLOGICAL BASIS OF ATRIAL FIBRILLATION

Рациональная фармакотерапия в кардиологии, 2015
Mechanisms of atrial fibrosis including the role of serotonin in the development of this lesion in patients with atrial fibrillation are presented. New approaches to the treatment of atrial fibrillation aimed at atrial fibrosis reduction are discussed.
O. M. Drapkina, A. V. Emelyanov
doaj   +5 more sources

Expression of tumor endothelial marker 1 in cardiac fibroblast contributes to atrial fibrosis in atrial fibrillation [PDF]

Scientific Reports
Atrial fibrosis is associated with atrial fibrillation (AF) and stroke. Tumor endothelial marker 1 (TEM1/CD248) is a transmembrane protein that appears in mesenchymal lineage-derived cells only during embryogenesis. Re-upregulation of TEM1 in fibroblasts
Yi-Heng Li, Yu-Ning Hu, Ting-Chun Huang, Mu-Shiang Huang, Hsing-Chun Chung   +4 more
doaj   +2 more sources

Atrial fibrosis by cardiac MRI is a correlate for atrial stiffness in patients with atrial fibrillation. [PDF]

Int J Cardiovasc Imaging, 2023
Abstract Aims: A relationship between left atrial strain and pressure has been demonstrated in many studies, but not in an atrial fibrillation (AF) cohort. In this work, we hypothesized that elevated left atrial (LA) tissue fibrosis might mediate and confound the LA strain vs.
Lamy J, Taoutel R, Chamoun R, Akar J, Niederer S, Mojibian H, Huber S, Baldassarre LA, Meadows J, Peters DC, FSCMR.   +10 more
europepmc   +4 more sources

Myocardial fibrosis and atrial fibrillation

Российский кардиологический журнал, 2018
Atrial fibrillation is the most prevalent arrhythmia, and tends to progress. Any structural changes in the heart may lead to its progressive remodelling with increased deposition of connective tissue and fibrosis. Predominance of collagen types I and III
S. V. Grigoryan, L. G. Azarapetyan, K. G. Adamyan   +2 more
doaj   +3 more sources

Collagen-targeted tracers for molecular imaging of atrial fibrosis and sensitive detection of atrial fibrillation [PDF]

npj Cardiovascular Health
Atrial fibrillation (AF), often accompanied by atrial fibrosis, is challenging to diagnose sub-clinically and reverse once established. Molecular imaging targeting excess atrial collagen may enable earlier detection of atrial fibrosis and its associated ...
Be’eri Niego, Christoph E. Hagemeyer, Bianca Jupp, Asif Noor, Paul S. Donnelly, Rong Xu, Thirimadura V. H. Mendis, Yi Ching Chen, Irena Carmichael, Julie R. McMullen, Karen Alt   +10 more
doaj   +2 more sources

Atrial myocyte-derived exosomal microRNA contributes to atrial fibrosis in atrial fibrillation

Journal of Translational Medicine, 2022
Background Atrial fibrosis plays a critical role in the development of atrial fibrillation (AF). Exosomes are a promising cell-free therapeutic approach for the treatment of AF.
Hongting Hao, Sen Yan, Xinbo Zhao, Xuejie Han, Ning Fang, Yun Zhang, Chenguang Dai, Wenpeng Li, Hui Yu, Yunlong Gao, Dingyu Wang, Qiang Gao, Yu Duan, Yue Yuan, Yue Li   +14 more
doaj   +3 more sources

Glutathione peroxidase 4 as a potential biomarker for atrial fibrosis and recurrence of atrial fibrillation [PDF]

Heart Rhythm O2
Background: Atrial fibrosis mediates the development and maintenance of atrial fibrillation (AF). Glutathione peroxidase 4 (GPX4) is a ferroptosis biomarker.
Tong Liu, MD, Dong-tao Zhou, ME, Fang Liu, MD, De-yong Long, MD, Yang Yang, MD, Meng-meng Li, MD, Xin Zhao, MD, Chang-yi Li, MD, Wei Wang, MD, Chen-xi Jiang, MD, Ri-Bo Tang, MD   +10 more
doaj   +2 more sources