Results 21 to 30 of about 98,834 (296)

Atrial fibrosis underlying atrial fibrillation (Review)

International Journal of Molecular Medicine, 2020
Atrial fibrillation (AF) is one of the most common tachyarrhythmias observed in the clinic and is characterized by structural and electrical remodelling. Atrial fibrosis, an emblem of atrial structural remodelling, is a complex multifactorial and patient‑specific process involved in the occurrence and maintenance of AF.
Li, Chang Yi, Zhang, Jing Rui, Hu, Wan Ning, Li, Song Nan   +3 more
openaire   +3 more sources

Age-related atrial fibrosis [PDF]

AGE, 2008
Many age-related diseases are associated with, and may be promoted by, cardiac fibrosis. Transforming growth factor (TGF)-beta, hypoxia-induced factor (HIF), and the matrix metalloproteinase (MMP) system have been implicated in fibrogenesis. Thus, we investigated whether age is related to these systems and to atrial fibrosis.
Gramley, F, Lorenzen, J, Knackstedt, C, Rana, O, Saygili, E, Frechen, D, Stanzel, S, Pezzella, F, Koellensperger, E, Weiss, C, Münzel, T, Schauerte, P   +11 more
openaire   +3 more sources

Regulation of Atrial Fibrosis by the Bone [PDF]

Hypertension, 2019
MR (mineralocorticoid receptor) antagonists have been demonstrated to provide beneficial effects on preventing atrial fibrosis. However, the underlying cellular and molecular mechanisms remain unclear. We aim to determine the role of osteoblast MR in atrial fibrosis and to explore the underlying mechanism.
Yi, Yi, Lili, Du, Mu, Qin, Xiao-Qing, Chen, Xue-Nan, Sun, Chao, Li, Lin-Juan, Du, Yuan, Liu, Yan, Liu, Jian-Yong, Sun, Zisheng, Tang, Min, Xu, Bing, Fang, Xu, Liu, Sheng-Zhong, Duan   +14 more
openaire   +2 more sources

Progressive and Simultaneous Right and Left Atrial Remodeling Uncovered by a Comprehensive Magnetic Resonance Assessment in Atrial Fibrillation

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Left atrial structural remodeling contributes to the arrhythmogenic substrate of atrial fibrillation (AF), but the role of the right atrium (RA) remains unknown.
Clara Gunturiz‐Beltrán, Marta Nuñez‐Garcia, Till F. Althoff, Roger Borràs, Rosa M. Figueras i Ventura, Paz Garre, Gala Caixal, Susanna Prat‐González, Rosario J. Perea, Eva Maria Benito, Jose Maria Tolosana, Elena Arbelo, Ivo Roca‐Luque, Josep Brugada, Marta Sitges, Lluís Mont, Eduard Guasch   +16 more
doaj   +1 more source

Atrial fibrillation and electrophysiology in transgenic mice with cardiac-restricted overexpression of FKBP12 [PDF]

, 2019
Cardiomyocyte-restricted overexpression of FK506-binding protein 12 transgenic (αMyHC-FKBP12) mice develop spontaneous atrial fibrillation (AF). The aim of the present study is to explore the mechanisms underlying the occurrence of AF in αMyHC-FKBP12 ...
Ai, Tomohiko, Chang, Po-Cheng, Chen, Hanying, Chen, Peng-Sheng, Fishbein, Michael C., Homsi, Mohamed, Li, Bai-Yan, Lin, Shien-Fong, Liu, Jijia, Liu, Ying, Maruyama, Mitsunori, Pan, Zhenwei, Rubart, Michael, Shou, Weinian, Xiao, Deyong   +14 more
core   +1 more source

LncRNA NRON promotes M2 macrophage polarization and alleviates atrial fibrosis through suppressing exosomal miR-23a derived from atrial myocytes

Journal of the Formosan Medical Association, 2021
Background/purpose: miR-23a is a pro-hypertrophic miRNA that inhibits M2 macrophage polarization. A previous study demonstrated that lncRNA NRON alleviated atrial fibrosis through suppression of M1 macrophages activated by atrial myocytes.
Jianan Li, Qingchun Zhang, Haimiao Jiao
doaj   +1 more source

Biatrial Remodeling in Patients with Cystic Fibrosis [PDF]

, 2019
BACKGROUND: Previous studies have focused on left and right ventricular remodeling in cystic fibrosis (CF), whereas atrial function has not been assessed in detail so far.
Cuspidi, Cesare, Dordevic, Aleksandar, Düngen, Hans-Dirk, Genger, Martin, Pieske, Burkert, Schwarz, Carsten, Tadic, Marijana, Tahirovic, Elvis   +7 more
core   +1 more source

Triggers for atrial fibrillation. the role of anxiety [PDF]

, 2019
Atrial fibrillation (AF) is the most widely recognized arrhythmia. Systemic arterial hypertension, diabetes, obesity, heart failure, and valvular heart diseases are major risk factors for the onset and progression of AF.
Ceccacci, Andrea, Fedele, Francesco, Lavalle, Carlo, Maestrini, Viviana, Mancone, Massimo, Maraone, Annalisa, Mariani, MARCO VALERIO, Pasquini, Massimo, Piro, Agostino, Severino, Paolo, Tarsitani, Lorenzo   +10 more
core   +1 more source

Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy. [PDF]

, 2016
BackgroundEstrogen pretreatment has been shown to attenuate the development of heart hypertrophy, but it is not known whether estrogen could also rescue heart failure (HF).
Bopassa, Jean C, Centala, Alexander, Eghbali, Mansoureh, Iorga, Andrea, Li, Jingyuan, Nadadur, Rangarajan D, Ren, Shuxun, Saito, Tomoaki, Sharma, Salil, Stefani, Enrico, Toro, Ligia, Umar, Soban, Wang, Yibin   +12 more
core   +1 more source

Hypercoagulability causes atrial fibrosis and promotes atrial fibrillation [PDF]

European Heart Journal, 2016
Atrial fibrillation (AF) produces a hypercoagulable state. Stimulation of protease-activated receptors by coagulation factors provokes pro-fibrotic, pro-hypertrophic, and pro-inflammatory responses in a variety of tissues. We studied the effects of thrombin on atrial fibroblasts and tested the hypothesis that hypercoagulability contributes to the ...
Spronk, Henri M.H., De Jong, Anne Margreet, Verheule, Sander, De Boer, Hetty C., Maass, Alexander H., Lau, Dennis H., Rienstra, Michiel, van Hunnik, Arne, Kuiper, Marion, Lumeij, Stijn, Zeemering, Stef, Linz, Dominik, Kamphuisen, Pieter Willem, ten Cate, Hugo, Crijns, Harry J., Van Gelder, Isabelle C., van Zonneveld, Anton Jan, Schotten, Ulrich   +17 more
openaire   +3 more sources