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Renal actions of atrial natriuretic factor [PDF]

Clinical Science, 1989
Cœur et excretion de Na. Facteur natriuretique auriculaire: sieges des actions intrarenales, mediation de la natriurese, facteurs modulant ces effets, influence de l'activite sympathique renale et de la pression de perfusion, clairance ...
J. G. G. Ledingham, J. G. Firth, A. E. G. Raine   +2 more
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Optimization of atrial natriuretic factor radioimmunoassay

Clinical Biochemistry, 1989
The development and long-term performance of a radioimmunoassay method for cardionatrin (C I = ANF 99-126) is described. The method was evaluated for accuracy, specificity and precision using different protocols and in various species. The antiserum raised against C I cross-reacts 100% with both human and rat C I and 122% with cardionatrin IV (C IV ...
Mercedes L. Kuroski de Bold, Adolfo J. de Bold, Inder R. Sarda   +2 more
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Atrial Natriuretic Factor in Untreated Hyperthyroidism

Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1990
Increased plasma concentration of atrial natriuretic factor (ANF) in untreated hyperthyroid patients is reported. A significant positive correlation between the concentration of ANF and serum thyroid hormones (T4 and T3) has been found when hyperthyroid patients and healthy controls were pooled together.
Stanislaw Czekalski, Tomasz Dutkiewicz, Jolanta Gozdzik, Urszula Majewska, Krystyna Widecka   +4 more
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Atrial Natriuretic Factor In Edematous Disorders

Annual Review of Medicine, 1990
This article provides a brief overview of atrial natriuretic factor (ANF). Considered by many investigators to be the putative "third factor" governing sodium excretion, ANF is a peptide actively secreted by the heart, with multiple target organ effectors. As such, ANF represents the first clearly documented cardiac hormone.
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Atrial natriuretic factor in human plasma

Biochemical and Biophysical Research Communications, 1986
A reproducible and sensitive radioimmunoassay (RIA) was developed to measure ANF in human plasma. Immunoreactive ANF was extracted from plasma with Sep-Pak cartridges, using 0.2% ammonium acetate (pH 4) with acetonitrile. The sensitivity of the assay was 3.9 pg/ml.
Marc Cantin, Denis Roy, Martial G. Bourassa, Gaétan Thibault, Raul Garcia, Jolanta Gutkowska, Raoul Bonan, Jacques Genest   +7 more
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Renal Effects Of Atrial Natriuretic Factor

Annual Review of Physiology, 1990
A prominent effect of atrial natriuretic factor (ANF), indeed that for which it is named, is the ability to effect a solute and water diuresis. The renal mechanisms responsible for this natriuresis and diuresis have been subjects of intensive inquiry since the hormone's discovery in 1981.
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Human Studies with Atrial Natriuretic Factor

Endocrinology and Metabolism Clinics of North America, 1987
The human heart secretes ANP, mainly or exclusively as the 1-28-amino-acid alpha-hANP. Secretion is increased when there is hypervolemia of the central circulation, either acute or chronic, the stimulus being, it is presumed, atrial stretch. The clearance rate of alpha-hANP has been documented in healthy volunteers but not in patients with clinical ...
M G Nicholls, A M Richards
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Atrial natriuretic factor in patients with acromegaly

European Journal of Clinical Pharmacology, 1990
In acromegaly the plasma volume is chronically elevated and it returns to normal when the disease is successfully treated. To define the role of ANF in such a chronic disorder of extracellular fluid volume homeostasis the plasma level was assayed in 37 acromegalic patients with active or inactive (successfully treated) disease.
C. Barthelemy, Geneviève Maistre, Gilbert Deray, Philippe Chanson, J. C. Legrand, Warnet A, Joëlle Eurin, Claude Jacobs, F. Masson, Jean Lubetzki, F. Martinez   +10 more
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Atrial Natriuretic Factor and Liver Disease

Hepatology, 1993
A working formulation for the role of ANF in the sodium retention of cirrhosis is summarized in Figure 4. Sodium retention is initiated early in cirrhosis, either as a result of hepatic venous outflow block or of primary vasodilation. The consequent intravascular volume expansion causes increases in ANF levels. At this stage of disease, the rise in ANF
Murray Epstein, Murray Epstein, Laurence M. Blendis, Leonard C. Warner, Karl Skorecki   +4 more
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Atrial Natriuretic Factors

1986
Various groups have recently reported on the existence of atrial natriuretic peptides (ANP) in secretorylike granules present in the myocytes of mammalian atria. These newly isolated peptides include the atrial natriuretic factors (ANF) (Grammer et al., 1983; Thibault et al., 1983a,b, 1984; Lazure et al., 1984; Napier et al., 1984a; Seidah et al., 1984)
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