Results 1 to 10 of about 402,338 (287)

The ChIP-seq-defined networks of Bcl-3 gene binding support its required role in skeletal muscle atrophy [PDF]

, 2012
NF-kappaB transcriptional activation is required for skeletal muscle disuse atrophy. We are continuing to study how the activation of NF-kB regulates the genes that encode the protein products that cause atrophy. Using ChIP-sequencing we found that Bcl-3,
Jackman, Robert W., Kandarian, Susan C., Wu, Chia-Ling   +2 more
core   +11 more sources

Usefulness of the Kyoto Classification Score for Prediction of Current Helicobacter pylori Infection [PDF]

The Korean Journal of Helicobacter and Upper Gastrointestinal Research, 2022
Background/Aims: Based on the Kyoto classification of gastritis, mucosal atrophy, endoscopic intestinal metaplasia, fold enlargement, nodularity, and diffuse redness may be associated with gastric cancer and Helicobacter pylori (H. pylori) infection.
Heejun Kang, Chul-Hyun Lim, Sukil Kim, Arum Choi, Jung-Hwan Oh   +4 more
doaj   +1 more source

Advances and limitations for the treatment of spinal muscular atrophy

BMC Pediatrics, 2022
Spinal muscular atrophy (5q-SMA; SMA), a genetic neuromuscular condition affecting spinal motor neurons, is caused by defects in both copies of the SMN1 gene that produces survival motor neuron (SMN) protein.
John W. Day, Kelly Howell, Amy Place, Kimberly Long, Jose Rossello, Nathalie Kertesz, George Nomikos   +6 more
doaj   +1 more source

Reliability and Validity of an Ultrasound-Based Protocol for Measurement of Quadriceps Muscle Thickness in Children

Frontiers in Physiology, 2022
Introduction and aims: Accurate determination of skeletal muscle size is of great importance in multiple settings including resistance exercise, aging, disease, and disuse.
Emil Rydell Högelin, Emil Rydell Högelin, Kajsa Thulin, Kajsa Thulin, Ferdinand von Walden, Ferdinand von Walden, Lotta Fornander, Lotta Fornander, Piotr Michno, Piotr Michno, Björn Alkner, Björn Alkner   +11 more
doaj   +1 more source

Hemifacial atrophy [PDF]

Dermatology Online Journal, 2013
We report the case of a 44-year-old woman with a one-year history of en coup de sabre morphea and progressive hemifacial atrophy with ipsilateral hemifacial neuralgia, migraine, and contralateral neurologic abnormalities. While rare, Parry-Romberg syndrome typically presents in the first or second decade of life; this patient's case is unusual in that ...
Vedvyas, Chetan, Urbanek, Richard W
openaire   +4 more sources

Preliminary Observations on Skeletal Muscle Adaptation and Plasticity in Homer 2^-/- Mice

Metabolites, 2021
Homer represents a diversified family of scaffold and transduction proteins made up of several isoforms. Here, we present preliminary observations on skeletal muscle adaptation and plasticity in a transgenic model of Homer 2-/- mouse using a multifaceted
Paola Lorenzon, Sandra Furlan, Barbara Ravara, Alessandra Bosutti, Gabriele Massaria, Annalisa Bernareggi, Marina Sciancalepore, Gabor Trautmann, Katharina Block, Dieter Blottner, Paul F. Worley, Sandra Zampieri, Michele Salanova, Pompeo Volpe   +13 more
doaj   +1 more source

Changes in Behaviour and Proxies of Physiology Suggest Individual Variation in the Building of Migratory Phenotypes in Preparation for Long-Distance Flights

Frontiers in Ecology and Evolution, 2022
Long-distance migration in birds is a complex syndrome that involves high energy costs and, in some species, substantial physiological re-organisation.
Tess Handby, Julia Slezacek, Sara Lupi, Kendrew Colhoun, Xavier A. Harrison, Stuart Bearhop   +5 more
doaj   +1 more source

Magnetic resonance imaging measures of brain volumes across the EXPEDITION trials in mild and moderate Alzheimer's disease dementia

Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022
Introduction Solanezumab is a monoclonal antibody that preferentially binds soluble amyloid beta and promotes its clearance from the brain. The aim of this post hoc analysis was to assess the effect of low‐dose solanezumab (400 mg) on global brain volume
Diana Otero Svaldi, Ixavier A. Higgins, Karen C. Holdridge, Roy Yaari, Michael Case, Luc Bracoud, David Scott, Sergey Shcherbinin, John R. Sims   +8 more
doaj   +1 more source

Altered Ca²⁺ Handling and Oxidative Stress Underlie Mitochondrial Damage and Skeletal Muscle Dysfunction in Aging and Disease

Metabolites, 2021
Skeletal muscle contraction relies on both high-fidelity calcium (Ca2+) signals and robust capacity for adenosine triphosphate (ATP) generation. Ca2+ release units (CRUs) are highly organized junctions between the terminal cisternae of the sarcoplasmic ...
Antonio Michelucci, Chen Liang, Feliciano Protasi, Robert T. Dirksen   +3 more
doaj   +1 more source

A Rare Case of Sporadic Inclusion Body Myositis (s-IBM) [PDF]

Journal of Clinical and Diagnostic Research, 2016
Sporadic inclusion body myositis (s-IBM) is an acquired inflammatory myopathy. Clinical presentation is variable. The usual presentation is progressive weakness and atrophy of the arms and leg muscles, especially of the quadriceps femoris which is ...
Sourya Acharya, Samarth Shukla, Pritum Kitey, Shameem Khan, SN Mahajan   +4 more
doaj   +1 more source