Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
Nature Communications, 2021 The thrombospondin (Thbs) family of secreted matricellular proteins are stress- and injury-induced mediators of cellular attachment dynamics and extracellular matrix protein production.
D. Vanhoutte +8 more
semanticscholar +1 more source
The value of hippocampal and temporal horn volumes and rates of change in predicting future conversion to AD. [PDF]
, 2012 Hippocampal pathology occurs early in Alzheimer disease (AD), and atrophy, measured by volumes and volume changes, may predict which subjects will develop AD.
ADNI investigators +5 more
core +1 more source
Progressive ataxia with oculo-palatal tremor and optic atrophy [PDF]
, 2013 The final publication is available at Springer via doi: 10.1007/s00415-013-7136-
A. M. Bronstein +17 more
core +1 more source
The Effect of Chronic Exposure with Imidacloprid Insecticide on Fertility in Mature Male Rats [PDF]
International Journal of Fertility and Sterility, 2010 Background This study was conducted to evaluate the effect of chronic exposure to imidacloprid (IM) insecticide on male testicular tissue, sperm morphology and testosterone levels in the serum of mature male rats.
Golamreza Najafi +4 more
doaj +1 more source
Polyphenols and Their Effects on Muscle Atrophy and Muscle Health
Molecules, 2021 Skeletal muscle atrophy is the decrease in muscle mass and strength caused by reduced protein synthesis/accelerated protein degradation. Various conditions, such as denervation, disuse, aging, chronic diseases, heart disease, obstructive lung disease ...
T. Nikawa, Anayt Ulla, Iori Sakakibara
semanticscholar +1 more source
An evidence-based algorithm for the utility of FDG-PET for diagnosing Alzheimer's disease according to presence of medial temporal lobe atrophy [PDF]
, 2015 BackgroundImaging biomarkers for Alzheimer's disease include medial temporal lobe atrophy (MTLA) depicted on computed tomography (CT) or magnetic resonance imaging (MRI) and patterns of reduced metabolism on fluorodeoxyglucose positron emission ...
Cam Donaldson +13 more
core +1 more source
Obesity Augments Glucocorticoid-Dependent Muscle Atrophy in Male C57BL/6J Mice
Biomedicines, 2020 Glucocorticoids promote muscle atrophy by inducing a class of proteins called atrogenes, resulting in reductions in muscle size and strength.
Laura C. Gunder +6 more
doaj +1 more source
Withaferin A and Ovarian Cancer Antagonistically Regulate Skeletal Muscle Mass
Frontiers in Cell and Developmental Biology, 2021 Cachexia is a complex wasting syndrome that overwhelmingly affects the majority of late-stage cancer patients. Additionally, there are currently no efficacious therapeutic agents to treat the muscle atrophy induced by the cancer.
Alex R. Straughn +3 more
doaj +1 more source
Nature Reviews Neurology, 2020 Early evaluation of treatment response and prediction of disease evolution are key issues in the management of people with multiple sclerosis (MS). In the past 20 years, MRI has become the most useful paraclinical tool in both situations and is used ...
J. Sastre-Garriga +20 more
semanticscholar +1 more source
Tissue Iron in Friedreich Ataxia
Journal of Integrative NeuroscienceHeart, dentate nucleus, and dorsal root ganglia (DRG) are targets of tissue damage in Friedreich ataxia (FA). This report summarizes the histology and histopathology of iron in the main tissues affected by FA.
Arnulf H Koeppen
doaj +1 more source