Results 41 to 50 of about 698,332 (299)

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Impact of α-synuclein fibril structure on seeding activity in experimental models of Parkinson’s disease

npj Parkinson's Disease
The central pathogenesis of Parkinson’s disease involves the misfolding and aggregation of α-synuclein (α-syn). There is a widespread belief that α-syn can propagate in a prion-like manner, and α-syn preformed fibrils (PFFs) have been widely used to ...
Junichiro Ohira, Masanori Sawamura, Kenichi Kawano, Risa Sato, Tomoyuki Taguchi, Tomoyuki Ishimoto, Jun Ueda, Masashi Ikuno, Shu-ichi Matsuzawa, Katsumi Matsuzaki, Ryosuke Takahashi, Hodaka Yamakado   +11 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Inorganic Arsenic Exposure Decreases Muscle Mass and Enhances Denervation-Induced Muscle Atrophy in Mice

Molecules, 2020
Arsenic is a toxic metalloid. Infants with a low birth-weight have been observed in areas with high-level arsenic in drinking water ranging from 463 to 1025 μg/L.
Chang-Mu Chen, Min-Ni Chung, Chen-Yuan Chiu, Shing-Hwa Liu, Kuo-Cheng Lan   +4 more
doaj   +1 more source

Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study

Science Advances, 2020
Brain atrophy in human epilepsy syndromes is explainable by network architecture and strongest in hub regions. Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome
S. Larivière, Raúl Rodríguez-Cruces, J. Royer, M. Caligiuri, A. Gambardella, L. Concha, S. Keller, F. Cendes, Clarissa Yasuda, L. Bonilha, E. Gleichgerrcht, N. Focke, M. Domin, Felix von Podewills, S. Langner, C. Rummel, R. Wiest, Pascal Martin, R. Kotikalapudi, T. O’Brien, B. Sinclair, L. Vivash, P. Desmond, S. Alhusaini, C. Doherty, G. Cavalleri, N. Delanty, R. Kälviäinen, G. Jackson, Magdalena A Kowalczyk, M. Mascalchi, M. Semmelroch, R. Thomas, H. Soltanian-Zadeh, E. Davoodi-bojd, Junsong Zhang, M. Lenge, R. Guerrini, E. Bartolini, K. Hamandi, S. Foley, B. Weber, C. Depondt, J. Absil, Sarah J. A. Carr, E. Abela, M. Richardson, O. Devinsky, M. Severino, P. Striano, D. Tortora, S. Hatton, S. Vos, J. Duncan, C. Whelan, P. Thompson, S. Sisodiya, A. Bernasconi, A. Labate, C. McDonald, N. Bernasconi, B. Bernhardt   +61 more
semanticscholar   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Comparative Evaluation of Pattern of Anterior Loop of Mandibular Canal in Dentulous and Edentulous Patients Using Cone Beam Computed Tomography: A Cross-Sectional Study

Journal of Indian Academy of Oral Medicine and Radiology
Background: Previous literature has discussed the prevalence of various patterns of anterior loops in male and female populations. We rarely encounter studies examining the patterns of anterior loops in dentulous and edentulous patients.
Kalyani Khairnar, Chetan Bhadage, Ajay Bhoosreddy, Madhura Barve   +3 more
doaj   +1 more source

Volumetric Assessment of Extratemporal Structures in Patients With Temporal Lobe Epilepsy

International Clinical Neuroscience Journal, 2022
Background: We assessed the presence of brain volume loss in the extratemporal structures in patients with temporal lobe epilepsy (TLE). The associations between brain volume loss in these structures and epilepsy duration, magnetic resonance imaging (MRI)
Marjan Asadollahi, Elham Rahimian, Ali Akbar Asadi-Pooya, Majid Tahsini, Hans-Jürgen Huppertz, Nayyereh Akbari, Leila Simani   +6 more
doaj   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source