Results 51 to 60 of about 768,160 (341)

Impact of α-synuclein fibril structure on seeding activity in experimental models of Parkinson’s disease

npj Parkinson's Disease
The central pathogenesis of Parkinson’s disease involves the misfolding and aggregation of α-synuclein (α-syn). There is a widespread belief that α-syn can propagate in a prion-like manner, and α-syn preformed fibrils (PFFs) have been widely used to ...
Junichiro Ohira, Masanori Sawamura, Kenichi Kawano, Risa Sato, Tomoyuki Taguchi, Tomoyuki Ishimoto, Jun Ueda, Masashi Ikuno, Shu-ichi Matsuzawa, Katsumi Matsuzaki, Ryosuke Takahashi, Hodaka Yamakado   +11 more
doaj   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Clinical Practice Guideline for Gastritis in Korea [PDF]

The Korean Journal of Helicobacter and Upper Gastrointestinal Research
Gastritis is a disease characterized by inflammation of the gastric mucosa. It is very common and has various classification systems such as the updated Sydney system.
Seung Joo Kang, Jae Gyu Kim, Hee Seok Moon, Myeong-Cherl Kook, Jong Yeul Lee, Chang Seok Bang, Chung Hyun Tae, Eun Jeong Gong, Su Youn Nam, Hyun Jung Kim,   +10 more
doaj   +1 more source

Cancer cell-derived exosomal miR-425-3p induces white adipocyte atrophy

Adipocyte, 2022
White adipose tissue wasting plays a critical role in the development and progression of cancer cachexia. However, the mechanism behind the loss of adipose tissue remains ill-defined.
Anwen Liu, Wenxia Pan, Shutong Zhuang, Yuanzhi Tang, Haitao Zhang   +4 more
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Comparative Evaluation of Pattern of Anterior Loop of Mandibular Canal in Dentulous and Edentulous Patients Using Cone Beam Computed Tomography: A Cross-Sectional Study

Journal of Indian Academy of Oral Medicine and Radiology
Background: Previous literature has discussed the prevalence of various patterns of anterior loops in male and female populations. We rarely encounter studies examining the patterns of anterior loops in dentulous and edentulous patients.
Kalyani Khairnar, Chetan Bhadage, Ajay Bhoosreddy, Madhura Barve   +3 more
doaj   +1 more source

Progressive ataxia with oculo-palatal tremor and optic atrophy [PDF]

, 2013
The final publication is available at Springer via doi: 10.​1007/​s00415-013-7136-
A. M. Bronstein, C Morgia, C. Everett, E Storey, G Deuschl, I. Peppas, K. Schmierer, KK Johansen, KL Howard, LI Lopez, M Samuel, M. M. Papachatzaki, N. Ali, P Amati-Bonneau, Q. Arshad, RK Naviaux, S Stricker, S. Cader   +17 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Inorganic Arsenic Exposure Decreases Muscle Mass and Enhances Denervation-Induced Muscle Atrophy in Mice

Molecules, 2020
Arsenic is a toxic metalloid. Infants with a low birth-weight have been observed in areas with high-level arsenic in drinking water ranging from 463 to 1025 μg/L.
Chang-Mu Chen, Min-Ni Chung, Chen-Yuan Chiu, Shing-Hwa Liu, Kuo-Cheng Lan   +4 more
doaj   +1 more source

Why musical memory can be preserved in advanced Alzheimer's disease [PDF]

, 2015
Musical memory is relatively preserved in Alzheimer's disease and other dementias. In a 7 Tesla functional MRI study employing multi-voxel pattern analysis, Jacobsen et al.
Chételat, Gael, Fritz, ThomasLW1780200091355331448AC4-F0EE-11E1-A9DE-61C894A0A6B4, Jacobsen, Jörn-Henrik, Kullmann, Dimitrieditor, Stelzer, Johannes   +4 more
core   +2 more sources