Results 51 to 60 of about 655,529 (373)
The multiphysics of prion-like diseases: progression and atrophy [PDF]
Phys. Rev. Lett. 121, 158101 (2018), 2018 Many neurodegenerative diseases are related to the propagation and accumulation of toxic proteins throughout the brain. The lesions created by aggregates of these toxic proteins further lead to cell death and accelerated tissue atrophy. A striking feature of some of these diseases is their characteristic pattern and evolution, leading to well-codified ...
arxiv +1 more source
Orphanet Journal of Rare Diseases, 2011 Abstract Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease characterized by degeneration of alpha motor neurons in the spinal cord, resulting in progressive proximal muscle weakness and paralysis. Estimated incidence is 1 in 6,000 to 1 in 10,000 live births and carrier frequency of 1/40-1/60.
D'Amico, Adele +3 more
openaire +4 more sources
AVRA: Automatic Visual Ratings of Atrophy from MRI images using Recurrent Convolutional Neural Networks [PDF]
, 2018 Quantifying the degree of atrophy is done clinically by neuroradiologists following established visual rating scales. For these assessments to be reliable the rater requires substantial training and experience, and even then the rating agreement between two radiologists is not perfect. We have developed a model we call AVRA (Automatic Visual Ratings of
arxiv +1 more source
Supraphysiologic Administration of GDF11 Induces Cachexia in Part by Upregulating GDF15
Cell Reports, 2018 Summary: The age-related effects of GDF11 have been a subject of controversy. Here, we find that elevated GDF11 causes signs of cachexia in mice: reduced food intake, body weight, and muscle mass.
Juli E. Jones +10 more
doaj +1 more source
Mayo Clinic Proceedings, 2010 Vulvovaginal atrophy (VVA) is a common and underreported condition associated with decreased estrogenization of the vaginal tissue. Symptoms include dryness, irritation, soreness, and dyspareunia with urinary frequency, urgency, and urge incontinence. It can occur at any time in a woman's life cycle, although more commonly in the postmenopausal phase ...
Maire B, Mac Bride +2 more
openaire +2 more sources
Identifying brain hierarchical structures associated with Alzheimer's disease using a regularized regression method with tree predictors [PDF]
arXiv, 2021 Brain segmentation at different levels is generally represented as hierarchical trees. Brain regional atrophy at specific levels was found to be marginally associated with Alzheimer's disease outcomes. In this study, we propose an L1-type regularization for predictors that follow a hierarchical tree structure.
arxiv
Genetic variants and magnetic resonance imaging measures in multiple sclerosis: a systematic review
Journal of Medical Science, 2016 Introduction. Although environmental factors play the major role in the etiopathogenesis of multiple sclerosis (MS), genetic factors are implicated as well.
Jan Krzysztof Nowak +7 more
doaj +1 more source
Endoscopic Prediction for Acid Reflux in Patients without Hiatus Hernia
The Korean Journal of Gastroenterology, 2020 Background/Aims: A diagnosis of gastroesophageal reflux disease is challenging in patients who have reflux symptoms but do not respond to proton pump inhibitors nor have reflux esophagitis and hiatal hernia (HH) on endoscopy.
Jun Young Kim +8 more
doaj +1 more source