Results 91 to 100 of about 84,826 (242)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Does Change in Attention Control Mediate the Impact of tDCS on Attentional Bias for Threat? Limited Evidence from a Double-blind Sham-controlled Experiment in an Unselected Sample

Psychologica Belgica, 2019
Neurocognitive models of attentional bias for threat posit that attentional bias may result from a decreased activation of the left prefrontal cortex, and especially of its dorsolateral part (dlPFC), resulting in an impaired attention control ...
Charlotte Coussement, Pierre Maurage, Joël Billieux, Alexandre Heeren   +3 more
doaj   +1 more source

Attention bias at baseline does not moderate the effect of attention bias modification for depressive symptoms

Neuroscience Applied
Abstract Background Clinical trials of Attention Bias Modification for depressive symptoms have consistently produced small effect sizes and mixed results. Therefore, identifying subpopulations for whom this intervention works has been called for.
Hallvard Solbø Hagen, Jan Ivar Røssberg, Catherine J. Harmer, Rune Jonassen, Nils Inge Landrø, Ragnhild Bø   +5 more
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Negative effects of an alternating-bias training aimed at attentional flexibility: a single session study

Health Psychology and Behavioral Medicine, 2017
Attentional Bias Modification (ABM) usually aims to induce automatic biases directed toward or away from certain stimulus categories. An alternative approach, termed Attention Control Training (ACT), uses a similar paradigm but aims to train the ability ...
Thomas E. Gladwin
doaj   +1 more source

Effects of attention bias modification for anxiety: Neurophysiological indices and moderation by symptom severity. [PDF]

Clin Neurophysiol, 2023
Dennis Tiwary TA, Cho H, Myruski S.
europepmc   +1 more source

Attention and Interpretation Bias Modification Transfers to Memory Bias: Testing the Combined Cognitive Bias Hypothesis

Cognitive Therapy and Research
Abstract Purpose This study delves into the combined cognitive bias hypothesis in depression, exploring the interaction between negative attention, interpretation and memory biases. We aimed to assess whether modifying attention and interpretation bias would lead to congruent changes in memory bias, and to what extend ...
Zhen Zhang, Janna N. Vrijsen, Alvaro Sanchez-Lopez, Ernst H.W. Koster, Eni S. Becker   +4 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Social anxiety and attentional bias to negative emotional information: the relationship and intervention

BMC Psychiatry
Background According to the cognitive behavioral model of social anxiety, attentional bias to negative emotional information causes and maintains anxiety.
Chen Liu, Jon D. Elhai, Christian Montag, Haibo Yang   +3 more
doaj   +1 more source